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DNA Replication Proteins and their Functions
N/A
7
Biology
Undergraduate 1
11/09/2010

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Term
Helicase
Definition
Unwinds parental double helix at replication forks
Term
Single-strand binding protein
Definition
Binds to and stabilizes single-stranded DNA until it can be used as a template
Term
Topoisomerase
Definition
Relieves "overwinding" strain ahead of replication forks by breaking, swiveling, and rejoining DNA strands
Term
Primase
Definition
Synthesizes an RNA primer at 5' end of leading strand and of each Okazaki fragment of lagging strand
Term
DNA pol III
Definition
Using parental DNA as a template, synthesizes new DNA strand by covalently adding nucleotides to the 3' end of a pre-existing DNA strand or RNA primer
Term
DNA pol I
Definition
Removes RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides
Term
DNA ligase
Definition
Joins 3' end of DNA that replaces primer to rest of leading strand and joins Okazaki fragments of lagging strand
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