Term
|
Definition
|
|
Term
| mech of action for osmotic diuretics |
|
Definition
they attract water into lumen of the renal tubules:
incr in urine vol and Na excretion |
|
|
Term
| clinical use of osmotic diuretics |
|
Definition
|
|
Term
|
Definition
Hypersensitivity
pul edema
dehydration
*dont give in anuria or CHF* |
|
|
Term
| What does aldosterone regulate in distal tubule and collecting duct |
|
Definition
Na channels
Na K ATPase pumps |
|
|
Term
| what is the effect of aldosterone on the urine? |
|
Definition
| Acidic causing plasma metabolic alkalosis |
|
|
Term
|
Definition
|
|
Term
| What is the mech of action for acetazolamide |
|
Definition
| reduce Bicarb formation that will reduce driving force for Na reabsorption |
|
|
Term
| What is the effect of acetazolamide on urine |
|
Definition
incr in volume
Na excretion
K excretion
HIGH HCO3 excretion
alkaline pH |
|
|
Term
| clinical use of acetazolamide |
|
Definition
reduce intraocular pressure
*mountain sickness*
urinary alk- treat met alk |
|
|
Term
|
Definition
hyperchloremic metabolic acidosis
neuropathy |
|
|
Term
| Major effect of Thiazide diuretic |
|
Definition
| inhibition of Na/Cl transport in distal tubule |
|
|
Term
| Major effect of Thiazide diuretic |
|
Definition
| inhibition of Na/Cl transport in distal tubule |
|
|
Term
| Major effect of Thiazide diuretic |
|
Definition
| inhibition of Na/Cl transport in distal tubule |
|
|
Term
| Effects of thiazide on the urine |
|
Definition
incr in volume
Na excretion
K increase
Ca excretion DECREASE (chronic use) |
|
|
Term
| Clinical use of thiazides |
|
Definition
*CHF*
kidney stones
diabetes insipidus |
|
|
Term
| Side effects of thiazides |
|
Definition
hypokalemia
hyperuricemia
hyperglycemia (DM)
incr cholesterol
hypercalcemia |
|
|
Term
|
Definition
| Furosemide and Ethacrynic acid |
|
|
Term
| These convey some inhibition of CA |
|
Definition
|
|
Term
| Loop diuretics block what |
|
Definition
|
|
Term
|
Definition
pul edema
oligouria or anuria
*hypercalcemia* |
|
|
Term
|
Definition
Plasm
HYPO: kalemia, natremia, magnesemia, calcemia
Metabolic alkalosis
**GOUT and OTOTOXICITY*** |
|
|
Term
|
Definition
sprion and epleronome- aldosterone antags
Direct- amiloride triamterene |
|
|
Term
| Aldos antag effect on urine |
|
Definition
alkalinization (decreased H excretion)
incr. Na |
|
|
Term
| this diuretic causes gynecomastia in men |
|
Definition
|
|
Term
| What are the causes of diuretic resistance? |
|
Definition
Nephrotic syndrome
hepatic cirrhosis or heart failure
NSAIDS
organic acid increase |
|
|
Term
| These improve urine formation in anuric or oligouric pts. w/reduced splanchnic blood flow |
|
Definition
|
|
