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Diuretics
Pharm II
23
Pharmacology
09/19/2012

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Cards

Term
Chlorothiazide (Diuril)
Definition
Thiazide Diuretic- prototype, TX for hypertension and CHF
Term
Hydrochlorothiazide (HCTZ)
Definition
Thiazide Diuretic- thiazide derivative, more popular, more potent
Term
Chlorthalidone
Definition
Thiazide Diuretic- thiazide derivative behaves like HCTZ, long duration, TX for HTN. better outcomes?
Term
Indapamide (Lozol)
Definition
Thiazide Diuretic Analog- lipid soluble, nonthiazide diuretic with long duration of action. Direct arterial vasodilation. Can be used in renal disease
Term
Metolazone (Zaroxolyn)
Definition
Thiazide Diuretic Analog- can be used in pt's with renal disease, drug does not rely on secretory process. More potent
Term
Furosemide (Lasix)
Definition
Loop Diuretic- high efficacy, DOC for reducing acute pulmonary edema of CHF, useful for hypercalcemia
Term
Bumetanide (Bumex)
Definition
Loop Diuretic- high efficacy, DOC for reducing acute pulmonary edema of CHF, useful for hypercalcemia
Term
Torsemide (Demadex)
Definition
Loop Diuretic- high efficacy, DOC for reducing acute pulmonary edema of CHF, useful for hypercalcemia
Term
Ethacrynic Acid
Definition
Loop Diuretic- high efficacy, DOC for reducing acute pulmonary edema of CHF, useful for hypercalcemia, higher AE of ototoxity
Term
Spironolactone (Aldactone)
Definition
Potassium Sparing Diuretic- competes with the aldosterone action & can overcome K+ deficiency. Synthetic aldosterone antagonist, most effetive for mild edema few days at a time
Term
Eplerenone (Inspra)
Definition
Potassium Sparing Diuretic- Aldosterone antagonist, less Estrogenic/steroid adverse effects
Term
Amiloride (Midamor)
Definition
Potassium Sparing Diuretic- decrease in Na/K exchange. Doesn't depend on aldosterone
Term
Triamterene (Dyrenium)
Definition
Potassium Sparing Diuretic- acts to retain K+, decrease in Na/K exchange. Doesn't depend on aldosterone
Term
Mannitol
Definition
Osmotic Diuretic- maintain urine flow following ingestion of toxic substances that produce renal failure, TX for increased ICP, (IV)
Term
Urea
Definition
Osmotic Diuretic- maintain urine flow following ingestion of toxic substances that produce renal failure, TX for increased ICP
Term
Acetazolamide (Diamox)
Definition
Carbonic Anhydrase Inhibitor- involved in the na/k/h exchange in proximal convoluted tubule, acidosis; weak diuretic. used for open angle glaucoma and mountain sickness
Term
Osmotic Diuretics MOA
Definition
increase the urine volume, results in water loss; does not affect Na
Term
Loop Diuretics MOA
Definition
block reabsorption of Na at the Loop of Henle
Term
Thiazide Diuretics MOA
Definition
block reabsorption of Na at the distal tubule
Term
Diuretic increase Ca++ reabsorption
Definition
Thiazides
Term
Diuretic causes loss of Ca++
Definition
Loop Diuretics
Term
Potassium- Sparing Diuretic MOA
Definition
Inhibit Na+ reabsorption, K+ secretion, & H+ secretion in the collecting tubule
Term
Osmotic Diuretic MOA
Definition
filters through the glomerulus, increase water excretion rather than Na+ excretion