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DIT Flashcards
Brain Tumors, Seizure Medications, MSK
59
Medical
Graduate
03/27/2013

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Cards

Term
What nerves run with each of the follow arteries?
Lateral thoracic artery
Posterior circumflex artery
Deep brachial artery
Brachial artery
Posterior interosseous artery
Definition
Lateral thoracic artery- long thoracic nerve
Posterior circumflex artery- axillary nerve
Deep brachial artery- radial nerve
Brachial artery- median nerve
Posterior interosseous artery- deep branch of the radial nerve
Term
What are the symptoms of a lesion to the inferior trunk of the brachial plexus?
Definition
Klumpke's palsy

Atrophy of thenar and hypothenar eminences
Atrophy of interosseous muscles
Sensory deficits on the medial side of the forearm and hand
Disappearance of the radial pulse upon moving the head toward the ipsilateral side
Term
What are the symptoms of a lesion to the superior trunk of the brachial plexus?
Definition
Erb-Duchenne palsy

Limb hangs by side (paralysis of abductors
Medially rotated (paralysis of lateral rotators)
forearm is pronated (loss of biceps)
Term
What nerve is damaged when a patient presents with: Claw hand
Definition
Ulnar or median
Term
What nerve is damaged when a patient presents with: Ape hand
Definition
Median nerve
Term
What nerve is damaged when a patient presents with: Wrist drop
Definition
Radial nerve
Term
What nerve is damaged when a patient presents with: Scapular winging
Definition
Long thoracic nerve
Term
What nerve is damaged when a patient presents with: Unable to wipe bottom
Definition
Thoracodorsal nerve
Term
What nerve is damaged when a patient presents with: Loss of forearm pronation
Definition
Median nerve
Term
What nerve is damaged when a patient presents with: Cannot abduct or adduct fingers
Definition
Ulnar nerve
Term
What nerve is damaged when a patient presents with: Loss of shoulder abduction
Definition
Axillary nerve
Term
What nerve is damaged when a patient presents with: Weak external rotation of the arm
Definition
Upper trunk (C5-6), suprascapular nerve
Term
What nerve is damaged when a patient presents with: Loss of elbox flexion and forearm supination
Definition
Musculocutaneous nerve
Term
What nerve is damaged when a patient presents with: Loss of wrist extension
Definition
Radial nerve
Term
What nerve is damaged when a patient presents with: Trouble initiating shoulder abduction
Definition
Suprascapular nerve
Term
What nerve is damaged when a patient presents with: Unable to abduct arm beyond 10 degrees
Definition
Axillary nerve
Term
What nerve is damaged when a patient presents with: Unable to raise arm above horizontal
Definition
Long thoracic nerve
Term
What nerve is most at risk of injury with a fracture of: the shaft of the humerus
Definition
Radial nerve
Term
What nerve is most at risk of injury with a fracture of: the surgical neck of the humerus
Definition
Axillary nerve
Term
What nerve is most at risk of injury with a fracture of: the supracondylar humerus
Definition
Median nerve
Term
What nerve is most at risk of injury with a fracture of: the medial epicondyle
Definition
Ulnar nerve
Term
What nerve is most at risk of injury with a anterior shoulder dislocation
Definition
Axillary nerve
Term
What nerve is most at risk of injury of the carpal tunnel
Definition
Median nerve
Term
A patient presents with decreased pain and temperature sensation over the lateral aspects of both arms. Where is the lesion?
Definition
Sphingomyelia (in the cervical spinal cord)
Term
Which primary brain tumor has:

Pseudopalisading necrosis
Definition
GBM IV
Term
Which primary brain tumor has:

Polycythemia
Definition
Hemangioblastoma

(Other tumors associated with EPO are RCC, HCC, and pheochromocytoma)
Term
Which primary brain tumor has:

Neurofibromatosis II
Definition
Schwannoma
Term
Which primary brain tumor has:

Associated with von Hippel-Lindau syndrome
Definition
Hemangioblastoma

VHL also associated with bilateral RCC, cavernous hemangiomas in skin, mucosa, organs, pheochromocytomas, AD, mutated tumor suppressor on Ch3
Term
Which primary brain tumor has:

Foamy cells, high vascularity
Definition
Hemangioblastoma
Term
Which brain tumor has:

Hyperprolactinemia (galacctorrea, amenorrhea, anovulation
Definition
Pituitary adenoma
Term
Which primary brain tumor has:

Psammoma bodies
Definition
Meningioma

Psammoma bodies also associated with serous cystadenocarcinoma and papillary thyroid cancer
Term
Which primary brain tumor has:

Fried egg appearance
Definition
Oligodendroglioma

Fried egg appearance cells also in seminomatous testiular cancer and HPV infected cervical cells (koilocytes)
Term
Which primary brain tumor has:

Perivascular pseudorosettes
Definition
Ependymoma

Radial arrangement of tumor cells around a vessel
Term
Which primary brain tumor has:

Bitemporal hemianopia
Definition
Craniopharyngioma (or pituitary adenoma)
Term
Which primary brain tumor has:

Worst prognosis of any primary brain tumor
Definition
GBM IV
Term
Which primary brain tumor has:

Child with hydrocephalus
Definition
Medulloblastoma or Ependymoma
Term
Which primary brain tumor has:

Homer Wright pseudorosettes
Definition
Medulloblastoma
Term
Which anesthetic fits the following description:

IV, associated with hallucinations and bad dreams
Definition
Ketamine
Term
Which anesthetic fits the following description:

IV, most common drug used for conscious sedation
Definition
Midazolam (benzodiazepine), fentanyl (opioid)
Term
Which anesthetic fits the following description:

Inhaled, side effect of hepatotoxicity
Definition
Halothane
Term
Which anesthetic fits the following description:

IV, used for rapid anesthesia induction and short duration of action
Definition
Propofol
Term
Which anesthetic fits the following description:

IV, decreased cerebral blood flow (important for brain surgery)
Definition
Thiopental (barbituate)

NB: Effect terminated by rapid redistribution into tissue (muscle and fat)
Term
Which anesthetic fits the following description:

Opioid that does not induce histamine release
Definition
Fentanyl
Term
Which anesthetic fits the following description:

High triglyceride content increases risk of pancreatitis with long term use
Definition
Propafol
Term
What is the mechanism of dantrolene?
Definition
Prevents release of Ca2+ from sarcoplasmia reticulum.

Used to reverse malignant hyperthermia syndrome and neuroleptic malignant syndrome
Term
Drug of choice for partial (simple and complex) and tonic-clonic seizures
Definition
Phenytoin, carbamazepine, valproic acid
Term
3 more drugs useful in partial and tonic clonic seizures (not phenytoin, carbamazepine, and valproic acid)
Definition
Lamotrigine, topiramate, gabapentin
Term
Drug of choice for absence seizures
Definition
Ethosuxomide (and valproic acid)
Term
Drug to treat status epilepticus
Definition
Benzodiazepines
Term
Drug to treat eclampsia
Definition
MgSO4
Term
Common side effects of epilepsy drugs
Definition
Sedation, diplopia, ataxia, nystagmus
Term
Additional side effects of phenytoin
Definition
Gingival hyperplasia
Hirsutism
Fetal Hydantoin Syndrome
SJS
Induces P450
Drug-induced Lupus
Term
Which anti-epileptics are teratogens?
Definition
Phenytoin, carbamazepine, valproic acid
Term
What drugs cause Stevens-Johnson syndrome?
Definition
Anti-seizure (Lamotrigine, Ethosuxomide, Phenytoin, Carbamazepine, Phenobarbital), Sulfonamides, Penicllins, Allopurinol
Term
What drugs are known to cause agranulocytosis?
Definition
Clozapine, Carbamazepine, Colchicine, PTU, Methimazole, Dapson

Agranulocytosis Could Certain Cause Pretty Major Damage
Term
Hepatotoxic anti-epileptics
Definition
Valproic acid, Carbamazepine
Term
Which anti-epileptics block Na+ channels?
Definition
Carbamazepine, Phenytoin, Lamotrigine, Topiramate, Valproic Acid
Term
Which anti-epileptics work by potentiating the inhibitory effects of GABA?
Definition
Valproic acid, Phenytoin, Benzodiazepines, Gabapentin, Topiramate, Tiagabine, Vigabatrin, Levetiracetam
Term
Which anti-epileptics block Ca2+ channels?
Definition
Ethosuxomide (thalamic T-type channels) and Gabapentin (high-voltage activated Ca2+ channels)
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