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diseases of the respiratory system
micro 261
45
Microbiology
Undergraduate 2
04/23/2015

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Term
upper respiratory tract consists of...
Definition
nose, nasal cavity and sinuses above it, pharynx, epiglottis
Term
lower respiratory tract consists of...
Definition
trachea, bronchi, bronchioles, alveoli sacs, alveoli, alveolar ducts
Term
upper respiratory tract defenses
Definition
nasal hair, ciliary escalatory, mucus, coughing/sneezing, secretory IgA
Term
lower respiratory tract defenses
Definition
mucus, alveolar macrophages, secretory IgA
Term
conducting division
Definition
nose, nasal cavity, pharynx, trachea, bronchi

provides rigid tubes for air to reach the lungs
Term
respiratory division
Definition
bronchioles, alveolar ducts, alveoli

sites of gas exchange; where respiration takes place
Term
accessory organs
Definition
diaphragm, intercostal muscles, sternum, ribs
Term
acute coryza
Definition
common cold; approx. 200 viruses; inflammation of the upper respiratory tract

complications: sinusitis, swollen glands, tonsillitis, ear infections, secondary infections, hacking cough, sneezing, watery discharge, itchy/scratchy throat
Term
Rhinoviruses and the common cold
Definition
10-40%; early fall, spring, summer; 110 distinct types; seldom produce serious illnesses
Term
Coronaviruses and the common cold
Definition
20%; winter and early spring; large % of adult colds; only 3-4 out of 30+ infect humans
Term
Respiratory syncytial virus (RSV)
Definition
10-15%; more severe respiratory illnesses
Term
Sinusitis
Definition
inflammation and/or infection of the sinuses; may be acute and last for a few weeks or chronic lasting for weeks-months

complications: severe headaches, pain in the upper jaw and teeth, swelling of the eyelids, possible fever and rhinitis
Term
Pharyngitis
Definition
caused by bacteria or viruses but bacteria is the worst; fewer than 20% require antibiotic therapy; determined through lab cultures what type of species has infected you

complications: rapid onset of throat pain worsened by swallowing, fever, inflammation, colored exudate, headache, initial absence of cough
Term
Pharyngitis caused by Strep
Definition
Streptococcus pyogenes; may produce fibrinolysis to lyse blood clots and streptolysins that are toxic to tissue cells, and red and white blood cells; a rise in IgM antibody indicates caused by strep; can lead to rheumatic fever and glomerulonephritis
Term
scarlet fever
Definition
group A streptococci that produces an erythrogenic toxin (due to lyrogenized bacteriophage; same thing that causes strep throat); treated by antibiotics

complications: rash, fever, sore throat, swollen glands
Term
Diphtheria
Definition
caused by Corynebacterium diphtheriae; toxin produced by lysogenized bacteriophage; can lead to myocarditis and low platelet counts; treated by antitoxin and antibiotics; we receive vaccination

complications: sore throat, fever, enlarged lymph nodes, painful skin lesions, membrane growth near tonsils
Term
tonsillitis
Definition
viral or bacterial infections; tonsils part of immune system

complications: inflammation, fever, headache, difficulty swallowing, swollen glands in neck, ear pain, sore throat
Term
epiglottitis
Definition
caused by Heophilus influenzae and strains of Strep and Staph; could result in ER trip; more common in kids

complications: swelling of all tissues surrounding glottis and narrows airway
Term
laryngitis
Definition
caused by viral infection and sometimes physical stress on larynx; not very serious; stay hydrated

complications: inflammation of vocal cords in larynx, hoarse/gravely voice, sore throat with possible fever, difficulty swallowing
Term
tracheitis
Definition
viral infection; usually no treatment required; can become severe if swelling causes panic

complications: inflammation of trachea, sore and burning sensation as air enters lungs, trachea feels raw with frequent coughing, sensation of swelling in windpipe
Term
bronchial tree
Definition
as conducting tubes become smaller, the amount of smooth muscle increases
large cartilaginous rings
primary, secondary, tertiary, down to smaller than a hair
Term
bronchioles
Definition
complete layer of circular smooth (rings) in stead of cartilage
lack cartilage support and mucus-producing cells
23 orders of branching
Term
whooping cough (Pertussis)
Definition
Bordetella pertussis; highly infectious with low mortality rate; symptom relief and sometimes antibiotics; children immunized; can be very long-term

complications: cold-like symptoms (catarrhal stage), sever coughing (paroxysmal stage), whooping noise during breathing btwn bursts of coughing until child may vomit (convalescence stage), mucous in airways
Term
Tuberculosis
Definition
bacteria; ⅓ currently infected and 1 person infected every second; 8 million people a year; 1.87 million people die; acid-fast bacterium Mycobacterium tuberculosis; a + test does not mean you have it; droplet infection; bacteria multiply and spread when macrophages lyse; treatment is drug cocktail; 12 month course of antibiotics
Term
complications from Tuberculosis
Definition
complications: prolonged coughing maybe with blood, fever, night sweats, unexplained weight loss, lesion (if not healed correctly can be very harmful bc releases bacteria into circulatory system), splitting headache
Term
pneumonia
Streptococcus pneumoniae (pneumococcal)
Definition
virulence due to capsule; most common pneumonia; mortality rate <1%

complications: fever, chest pain, difficulty breathing, sputum rust-colored from blood
Term
pneumonia
Klebsiella pneumoniae
Definition
virulence due to capsule; caused by different types of organisms; common in throat and mouth; similar to Strep. pneumonia; mortality rate in untreated cases is 85%

complications: produces lung abscesses and permanent damage
Term
pneumonia
Mycoplasma Pneumonia (mycoplasmal pneumonia)
Definition
do not produce cell walls; more difficult to diagnose; more common in upper respiratory tract; very low mortality rate; not person to person transmission

complications: low fever, cough, headache
Term
pneumonia
Legionella pneumophila (Legionnaires Disease)
Definition
transmitted by water (air conditioning and fountains); can be fatal; needs to be diagnosed and treated quicker than other types

complications: sudden onset w/ high fever, cough, chest pain
Term
Viral pneumonia
Definition
complication of influenza or even chickenpox; not very common; most common in infants; considered viral if bacterium cannot be isolated from pneumonia patients
Term
Influenza
Definition
caused by variety of viruses; 1-2 week recovery; different types differentiated by H and N antigens on virus surface; He help virus attach to cell, N help to separate

complications: chills, fever, dry cough, sore throat, stuffy nose, headache, general muscular aches
Term
influenza type A
Definition
most common and serious
Term
influenza type B
Definition
can cause epidemics, but milder than type A
Term
influenza type C
Definition
never causes epidemics, mild
Term
Histoplasmosis - Histoplasma capsulatum
Definition
fungal disease of lower respiratory system; resembles tuberculosis; passes for minor respiratory infection; found along ohio and mississippi rivers; airborne spores (bird and bat droppings provide nutrients for growth of fungus)

complications: lesions on organs, signs and symptoms of tuberculosis
Term
Coccidiodomycosis - Coccidioides immitis
Definition
endemic to dry, alkaline soils of southwest; less than 100 deaths; aerosol spread; forms spherules containing spores in tissues

complications: tuberculosis signs/symptoms
Term
Pneumocystis pneumonia - Pneumocystis carinii
Pneumocystic jiroveci
Definition
fungus or protozoan; present in lungs of most healthy mammals; causes disease in immunosuppressed people (especially AIDS patients)

complications: shortness of breath, fever, nonproductive cough; more serious cases include blood in sputum, great difficulty breathing, chest pain
Term
asthma
Definition
allergy; swollen bronchioles

complications: labored breathing, wheezing, chest tightness, inflammation, bronchospasm, airways thickened with inflammatory exudates
Term
bronchitis
Definition
inflammation of the bronchi; acute or chronic
Term
Bronchiolitis
Definition
inflammation of the bronchioles; airway becomes obstructed from swelling of bronchiole walls
Term
cystic fibrosis
Definition
constant build up of mucous in the lungs;
Term
emphysema
Definition
destruction of alveolar tissue; from smoking or inhalation of toxic substances; air sacs i lungs progressively enlarge and can't empty completely before you exhale again; trapped air results in flattening of diaphragm and make you feel short of breath; weakened and collapsed air sacs with excess mucus
Term
Chronic Obstructive Pulmonary Disease (COPD)
Definition
exemplified by chronic bronchitis and obstructive emphysema; develop respiratory failure; history of smoking, labored breathing that only gets worse, coughing and frequent pulmonary infections
Term
Lung Cancer
Definition
⅓ of cancer deaths in US; over 90% of patients are smokers
Term
Tobacco (Nicotinianum tobacum)
Definition
4k different chemicals; nicotine very addictive and deadly poisonous; tar has ammonia, arsenic, cyanid, catechols, formaldehyde; basically carbon monoxide poisoning
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