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Disease and the Human Body: Reproductive Systems
Anatomy and common diseases of the male and female human reproductive systems
99
Pathology
Undergraduate 1
02/04/2010

Additional Pathology Flashcards

 


 

Cards

Term

 

 

Dartos Muscle

Definition

 

a muscle located below the testicles in the

scrotal sac which relaxes/contracts to pull

the testicles in closer to the body, in order to

keep them at optimal temperature (95°-96ºF)

Term

 

 

Cremaster Muscle

Definition

 

a muscle located in the lateral walls of the

scrotal sac which relaxes/contracts to pull

the testicles up closer to the body, in order to

keep them at optimal temperature (95°-96ºF)

 

Term


Tunica Vaginalis

Definition

 

the layer of tissue from the pelvic cavity lining

that surrounds the testicles

Term

 

 

Processus Vaginalis

Definition
the cavity located in the pelvic cavity inferior to the visceral organs, formed by the descent of the testicles into the scrotum.  Eventually closes off.
Term

 

 

Cryptorchidism (Condition)

Definition

 

 

the condition that refers to any testis that is not in the scrotum.  

 

Term

 

 

Cryptorchidism (Incidence)

Definition

 

about 30% in all premature males;

1% - 3% of all full term males

Term

 

 

Cryptorchidism (Etiology)

Definition

 

 

unknown; perhaps due to hormone deficiency

Term

 

 

Cryptorchidism (Problems)

Definition

 

if left untreated, infertility or sterility may occur at puberty

Term

 

 

Cryptorchidism (Treatment)

Definition
Orchiopexy is needed to retrieve and secure the testicle;  however, often the undescended testicles will descend into the scrotum on their own in the first 3 months after birth.
Term

 

 

Hydrocele (Condition)

Definition

a collection of fluid found anywhere along the length of the processus vaginalis

 

Term

 

 

Hydrocele (Etiology)

Definition

 

 

an opening in the processus vaginalis

Term

 

 

Hydrocele (Problems)

Definition
increased size of scrotum causes pain and occasionally the hydrocele may obstruct blood flow
Term

 

 

Hydrocele (Treatment)

Definition

these may be aspirated (drained) but fluid usually

re-accumulates.  Surgery may be necessary to close the

processus vaginalis.

Term

 

 

Testicular Torsion (Condition)

Definition

 

a twisting of the spermatic cord which may occur in newborns but most often in young boys.

Term

 

 

Testicular Torsion (Problems)

Definition
this causes pain, impaired blood flow and localized swelling; if torsion is present for more than 24 hours the survival of the testicle is doubtful due to the lack of blood flow.
Term

 

 

Testicular Torsion (Treatment)

Definition
With early detection, surgery may be performed to open the scrotum, untwist the spermatic cord, and secure the testicle to the scrotal wall at multiple sites.
Term

 

 

Testicular Cancer (Incidence)

Definition
these tumors represent the most common tumors of men between 20 and 34 years of age in the U.S.
Term


Testicular Cancer (Problems)
Definition
pain, infertility, and spread to other organs
Term

 

 

Testicular Cancer (Treatment)

Definition

95% of tumors involve seminiferous tubules cells; treatment of testicular cancer can be complicated:

  1. after diagnosis, removal of testis/spermatic cord
  2. if cancer has spread, removal of lymph nodes
  3. radiation and/or chemotherapy may be needed

Term

 

 

Carboplatin

Definition
a drug that replaces weeks of radiation therapy with just one dose.  proven to be 72% more effective in preventing cancerous growth in the remaining testicle after 5 years than radiation therapy.
Term

 

 

Spermatogenesis

Definition
the sequence of events leading to the production of sperm
Term

 

 

Seminiferous Tubules

Definition
highly coiled tubular structures found within each testicle, in which sperm cells are first created
Term

 

 

Sertoli Cells

Definition
large cells within the seminiferous tubules which protect the developing sperm from the body's immune system
Term

 

 

Interstitial Cells

Definition
cells located within the testicles, intermediate to the coils of the seminiferous tubules which produce the male sex hormone testosterone
Term

 

 

ICSH

Definition
stands for interstitial cell stimulating hormone; released by the brain at puberty; stimulates the interstitial cells to produce testosterone
Term

 

 

FSH

Definition
stands for follicle stimulating hormone; stimulates the Sertoli cells to produce ABP
Term

 

 

ABP

Definition
stands for androgen binding protein; allows the developing sperm to bind to the testosterone and spermatogenesis is induced.
Term

 

 

Pathway of developing sperm

Definition

 

  1. seminiferous tubule
  2. epididymis
  3. ductus (vas) deferens

 

Term

 

 

Epididymis 

Definition
a 20 foot long coiled tube attached to the testicle; it functions to store the immature (nearly motile) sperm.
Term

 

 

Epididymitis

 

Definition
the inflammation of the epididymis most often caused by neisseria gonorrhoeae, the the bacterium responsible for gonorrhea
Term

 

 

Gonorrhea

Definition
the most common sexually transmitted disease; male symptoms include inflammation of the urethra, pain in urination, and a urethral discharge of pus.
Term

 

 

Gonorrhea (Prevention & Treatment)

Definition
the best prevention is abstinence and safe sex; the drug of choice is Cipro, however, Cipro resistant strains are known.
Term

 

 

Ductus (vas) Deferens

Definition
an 18 inch long tubular structure that extends from the epididymis to the prostate; it functions to store mature (motile) sperm.
Term

 

 

Vasectomy

Definition

Voluntary sterilization of the male; a section of the ductus deferens is surgically removed near the epididymis.

 

Term

 

 

Seminal Vesicles

Definition
glands that secrete a fluid that contains mainly fructose, which is used as an energy on their voyage
Term

 

 

Ejaculatory Ducts

Definition
a continuation of the duct system inside the prostate; located at the union of the ductus deferenes and the seminal vesicles
Term

 

 

Prostate

Definition

accessory gland located below the urinary bladder of males; secretes an acidic fluid which contains:

 

  1. citric acid (nutrients)
  2. seminalplasmin (bactericidal)
  3. prostate specific antigen (PSA; liquifies semen)

 

Term

 

 

DRE

Definition
stands for digital (finger) rectal exam; screening test for possible prostate or seminal vesicle problems
Term

 

 

Benign Prostatic Hypertrophy (BPH)

[Condition & Incidence]

Definition
the enlargement of the prostate; occurs in approximately 80% of males over 60
Term

 

 

Benign Prostatic Hypertrophy (BPH)

[Etiology & Symptoms]

 

Definition
unknown cause; some symptoms are prostatic urethral constriction and difficult and painful urination
Term

 

 

Benign Prostatic Hypertrophy (BPH)

[Detection]

Definition
detected by digital rectal exam (DRE); or transrectal ultrasonography (TRU)
Term

 

 

Benign Prostatic Hypertrophy (BPH)

[Treatment]

Definition
treatment usually involves the removal of the overgrowth by a TURP (Transurethral Removal of the Prostate) with a wire filament; in some cases a prostatectomy is needed
Term

 

 

Prostate Cancer (Etiology & Incidence)

Definition
unknown cause; 2nd leading cause of death from cancer in males in the U.S.
Term

 

 

Prostatic Cancer (Symptoms)

Definition
similar symptoms to BPH but as the tissue grows it invades the surrounding tissues and becomes painful.
Term

 

 

Prostatic Cancer (Detection)

Definition
DRE, TRU, or biopsy are the main methods of detection; blood tests may also be done, Serum Prostate - Specific Agent may be elevated in a benign case.
Term

 

 

Prostatic Cancer (Treatment)

Definition

treatment depends on the stage and the age/health of the patient:

  1. radiation therapy
  2. prostatectomy
  3. hormone therapy (blocks testosterone)
  4. antiangiogenesis drugs
  5. IRESSA - inhibits cell division

Term

 

 

Urethra (3 Sections)

Definition

  1. Prostatic:  the portion found in the prostate
  2. Membranous:  portion between prostate and penis
  3. Penile:  portion found in the penis

Term

 

 

Bulbourethral Glands

Definition
2 small glands attached to the base of the penis that secrete a small amount of thick clear basic fluid during sexual arousal.
Term

 

 

Male pseudohermaphroditism

Definition

caused by either inadequate amounts of testosterone or by delayed development of reproductive organs; results in external genitalia that look female

 

Term

 

 

Hypospadias (Condition & Incidence)

Definition
1% of male births; occurs when the urethral folds do not fuse together along the entire length
Term

 

 

Hypospadius (Etiology)

Definition
unknown cause; may occur due to testosterone imbalances, mother's steroid use during pregnancy or dietary factors
Term

 

 

Epispadias (Condition)

Definition
urethral opening on the top of the penis; can be related to extrophy of the bladder which occurs when the abdominal wall does not form below the navel; corrected with tissue grafting
Term

 

 

Sterility (Etiology)

Definition
may be a genetic problem, but could also stem from the degradation of the seminiferous tubules
Term

 

 

Impotence

Definition
erectile dysfunction; the inability to achieve and/or maintain an erection; could be related to physical or psychological problems
Term

 

 

Impotence (Non-oral Treatment)

Definition
injections of prostaglandins (Caverject & Edex) and urethral suppositories of prostaglandins (Muse)
Term

 

 

Oogenesis

Definition
the sequence of events leading to the development of the egg cell
Term

 

 

LH in Women

Definition
luteinizing horomone; the hormone responsible for causing the primary oocyte to divide into a secondary oocyte and and a polar body.
Term

 

 

FSH in Women

Definition

follicle stimulating hormone; primarily responsible for increasing the number of granulosa cells

 

Term


corpus luteum
Definition
created by LH after the release of the secondary oocyte from the ovary; produces hormones estrogen and progesterone
Term

 

 

Estrogen

Definition
hormone that prepares the uterus for implantation and causes the development of the female's secondary sex characteristics
Term

 

 

Progesterone

Definition
hormone that helps prepare the uterus for implantation
Term

 

 

Birth Control Pills

Definition
contain either menstranol (synthetic estrogen) and norethynodrel/norethinodrine (synthetic progesterone) which inhibit the brain from producing LH and FSH, thus no egg is produced
Term

 

 

Morning-After Pill

Definition

essentially birth control pills but with much higher doses of estrogen and progestin; three possible results:

  1. change the uteral lining to prevent implantation
  2. inhibit or delay ovulation
  3. impede tubal transport of egg or sperm

Term

 

 

RU-486 "Abortion Pill"

Definition
functions by inhibiting the production of progesterone which directs the flow of nutrients to the uteral lining during pregnancy; can be taken through the 49th day of pregnancy 
Term

 

 

8th Week of Fetal Development

Definition
stage of fetal development in which brain waves and a heart beat are detectable
Term

 

 

Ovarian Cysts (Etiology & Condition)

Definition
unknown cause; usually sacs on an ovary that contain fluid or semisolid material
Term

 

 

Ovarian Cysts (Symptoms)

Definition
normally small ones produce no symptoms; however large ones can be painful; the main problem is when they rupture because this may result in hemorrhage.
Term

 

 

Ovarian Cysts (Treatment)

Definition
usually they diminish or rupture on their own within 60 days; however if they persist, surgery may be necessary
Term


Ovarian Cancer (Condition, Incidence & and Etiology)
Definition
the uncontrolable growth of the ovarian tissue; the 4th leading cause of female cancer; cause is unknown
Term

 

 

Ovarian Cancer (Symptoms)

Definition
symptoms include abdominal swelling, abdominal pain, non-menstrual bleeding, weight loss, problems with urination, and constipation
Term

 

 

Ovarian Cancer (Detection)

Definition

 

  1. transvaginal sonography - for early stages
  2. MRI - good for visualizing soft tissue
  3. Blood tests - CA125 - predictive value of 25%
  4. proteomic fingerprinting - detection of multiple proteins 

 

Term


Ovarian Cancer (Treatment)
Definition
usually includes the removal of the uterus, ovaries, and oviducts. radiation and chemotherapy may be used along with surgery
Term

 

 

Uterine Tubes/Oviducts/Fallopian Tubes

(4 Parts)

Definition

  1. infundibulum:  closest part to the ovary
  2. ampula: the longest part 
  3. isthmus:  narrowed portion
  4. interstitial segment:  the part that connects to the uteral opening 

Term

 

 

Tubular Pregnancy (Condition)

Definition
since the fertilization of the egg occurs in the oviduct, this is a common place for the egg to implant itself and begin enlarging
Term

 

 

Ectopic Pregnancy

Definition
a pregnancy that occurs anywhere but the uterus; 90-95% occur in the oviduct
Term

 

 

Tubular Pregnancy (Symptoms & Problems)

Definition
symptoms are abdominal pain and discomfort; complications include enlargement, rupture, and subsequent hemorrhage of the uterine tube.
Term

 

 

Tubular Pregnancy (Treatment)

Definition
treatment includes the removal of the oviduct (salpingectomy), recently some developing eggs have been removed and transplanted to the uterus with minimal success (15%)
Term

 

 

Salpingitis (Condition)

Definition
an inflammation of the oviducts which may be caused by untreated sexually transmitted disease or bacterial invasion (staph/streph)
Term

 

 

Pyosalpinx (Condition)

Definition
when pus accumulates in the oviducts due to a bacterial invasion and the tubes swell shut
Term

 

 

Hydrosalpinx (Condition)

Definition
after salpingitis subsides with antibiotic treatment, the tubes become filled with a watery fluid
Term

 

 

Salpingitis (Problems & Recognition)

Definition
the swelling may cause the adhesion of tubes to eachother, blocking off the tube which can be detected by a hysterosalpingogram
Term

 

 

Tubal Ligation

Definition
a voluntary sterilization technique which involves the removal of a portion of each oviduct and tying the ends off
Term

 

 

Laparoscopy

Definition
surgical opening of the pelvic cavity and inflating it in order to operate on the organs
Term

 

 

Uterine Lining (3 Layers)

Definition

  1. perimetrium - outermost layer
  2. myometrium - muscular middle layer
  3. endometrium - innermost layer which consists of the basal layer and the functional layer
endometrium displays constant activity of alternating growth and removal of the functional layer

Term


Amenorrhea - The absence of mensturation
(3 Categories)
Definition

  1. Normal - before puberty and after menopause
  2. Primary - failure to menstruate once puberty is reached; caused by low estrogen levels
  3. Secondary - cessation of menstruation in women who previously had normal periods; caused by hormonal disturbances and psychological factors

Term

 

 

Dysmenorrhea (Condition & Etiology)

Definition
painful or difficult menstruation that may be accompanied by severe menstrual cramps; caused by the overproduction of prostaglandins which induce uterine contractions; treated by prostaglandin inhibitors like ibuprofen and naproxen 
Term

 

 

Menorrhagia

Definition
excessive menstrual bleeding during period
Term

 

 

Metorrhagia

Definition

spotting between menstrual periods

 

Term

 

 

Hypomenorrhea

Definition
deficient amounts of menstrual flow
Term

 

 

Oligomenorrhea

Definition
infrequent menstruation
Term

 

 

Polymenorrhea

Definition
increased frequency of menstruation
Term

 

 

Uterine Prolapse

Definition
the descent of the uterus into the vagina; occurs when supporting ligaments relax; treatment involves tightening of the pelvic support as well as the insertion of a pessary which holds the uterus in place
Term

 

 

Pelvic Inflammatory Disease (Condition)

Definition
inflammation of the oviducts due to the destruction of the cervical mucus which creates the bacteriostatic envronment
Term

 

 

Pelvic Inflammatory Disease (Symptoms)

Definition
abdominal pain/tenderness, fever, and pus like discharge
Term

 

 

Pelvic Inflammatory Disease (Treatment)

Definition
treatment involves the introduction of antibiotic agents in the form of pelvic washes; if the infection is significant then it may become life threatening and the removal of ovaries, oviducts and uterus
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