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digestive
digestive
48
Anatomy
Undergraduate 2
03/26/2011

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Term
Ingestion
Definition
taking food into the mouth
Term
Movement of Food
Definition
the passage of food along the gastrointestinal (GI) tract
Term
Digestion
Definition
the breakdown of food by chemical and mechanical means
Term
Absorption
Definition
the passage of digested food from GI tract into bloodstream (and lymph) for distribution to cells
Term
Defecation
Definition
the elimination of undigested material
Term
DIGESTIVE SYSTEM
Definition
Ingestion Movement of Food Digestion Absorption Defecation
Term
DIGESTIVE ORGANS
Definition
Alimentary canal (GI Tract) 
◦ mouth
◦ pharynx
◦ esophagus
◦ stomach
◦ small intestine
◦ large intestine
Term
Accessory organs
Definition
◦ salivary glands
◦ liver
◦ gallbladder
◦ pancreas
Term
DIGESTIVE TISSUES
Definition
MUCOSA
SUBMUCOSA 
MUSCULARIS 
SEROSA
Term
MUCOSA
Definition
= innermost 
} composed of epithelium + CT (areolar); and small amounts of smooth muscle
} contains many glands that secrete mucus
} functions:
◦ protection
◦ secretion
◦ absorption (of nutrients)
Term
SUBMUCOSA
Definition
= beneath mucosa 
} composed of areolar CT, blood vessels, lymph vessels, and nerves;
} functions:
◦ nourishment of mucosa
◦ carrying absorbed nutrients away
Term
MUSCULARIS
Definition
2 layers of muscle
} circular muscle layer around submucosa
} longitudinal layer around circular layer
} function: movements of food through canal (mixing & peristalsis)
Term
SEROSA
Definition
outermost layer 
} visceral peritoneum
} functions:
◦ lubrication
◦ free movement of canal in abdominal cavity
Term
PERISTALSIS
Definition
Smooth muscle is arranged in 2 layers at right
angles to each other:
} When circular muscles contract the lumen constricts and the organ lengthens
} When longitudinal muscles contract it shortens and dilates
} This results in a rhythmic motion called? 
} This is also  how earthworms crawl
Term
INGESTION
Definition
Oral cavity
} Intake of food
◦ Mechanical digestion = physical breakdown of food by tongue and teeth
Taste
} Forms bolus for swallowing
} Initiates swallowing process
◦ Chemical digestion = breakdown of molecules by enzymes
Term
TEETH
Definition
First teeth (20)
} = Deciduous, baby or milk teeth
} Second teeth (32)
} = permanent, adult teeth
} Every tooth has a specific job
Term
Incisors (8)
Definition
used for cutting food.
Term
Canines (4)
Definition
 = cuspids 
– used for tearing food.
Term
Premolars (8)
Definition
= bicuspids
– used for crushing and tearing
Term
Molars (12)
Definition
– used for grinding
Term
Crown
Definition
◦ Only part normally seen
◦ Covered in enamel
Term
Gum line 
Definition
Where the tooth and the gums meet
Term
Root
Definition
 part of the tooth embedded in bone. 
◦ The root makes up about two-thirds of the tooth and holds the tooth in place 
Term
Enamel
Definition
Hardest tissue in the body 
Term
Dentin
Definition
 Layer of the tooth under the enamel
Term
Pulp
Definition
Soft tissue found in the center of all teeth, where the nerve tissue and blood vessels are.
Term
SALIVARY GLANDS
Definition
Basic secretory units of salivary glands = acini (clusters of cells)
Term
2 major types of cells in acini
Definition
◦ Serous
– Secrete watery fluid, rich in amylase (enzyme)
◦ Mucous
– Secrete thick mucous
Term
3 sets of glands
Definition

 Parotid

Submandibular 

Sublingual

Term
Parotid 
Definition
Largest
Term
Submandibular
Definition
 Equal in serous and mucous cells
– More viscous secretion
Term
Sublingual
Definition
– Smallest
– Mostly mucous cells
Term
SALIVARY GLANDS/SALIVA
FUNCTIONS
Definition
 Start chemical digestion of starches, amylose
} Moisten and lubricate food for swallowing
} Put food into solution for tasting
} Moisten mouth
Term
SALIVARY GLANDS
Definition
Basic secretory units of salivary glands = acini (clusters of cells)
Term
SALIVA COMPOSITION
Definition
99.4% water
} 0.6% includes:
◦ mucus
◦ antibodies
◦ Enzymes/amylase
◦ other
Term
TONGUE
Definition
Voluntary muscle
} Functions
◦ Mechanical digestion
◦ Sense of taste
◦ Aides in swallowing
◦ Aides in speech
Term
SWALLOWING
Definition
Initiated voluntarily then
proceeds automatically
} Divided in 3 phases:
◦ Buccal 
– Compression of bolus against hard palate
– Tongue forces bolus into oropharynx
– Nasopharynx sealed off by uvula
◦ Pharyngeal
– Bolus moves by peristalsis
◦ Esophogeal 
– Contraction of pharyngeal muscles forces bolus into esophagus 
– ESOPHAGUS
Term
STOMACH
Definition
Functions mainly in storing food and mixing it with gastric juice to form chyme 
} Other functions include:
◦ Chemical digestion of proteins
◦ Secretion of intrinsic factor – a chemical that is necessary for vitamin B12 absorption. ( B12 is necessary for RBC synthesis)
◦ Destruction of bacteria by hydrochloric acid
◦ Absorption of water, aspirin, and alcohol
Term
STOMACH
Definition
The gastric pits lead into gastric glands, which secrete the gastric juice (2-3 L/ day). The basic cell types are:
◦ Mucous neck cells –
– upper portion of gland 
– Secrete acidic mucus 
◦ Chief cells –secrete pepsinogen, an inactive form of pepsin (Pepsinogen is activated by HCl and by pepsin itself)
◦ Parietal cells –
– mid-portion of glands 
– Secrete hydrochloric acid and intrinsic factor.
◦ Enteroendocrine cells – secrete multiple hormones into the plasma. An example is gastrin, a hormone that regulates the stomach’s motility and secretory activity.
Term
SMALL INTESTINE
Definition
Site of most digestion and almost all nutrient absorption
} Longest part of the alimentary tube
} 3 sections: 
◦ duodenum 
◦ jejunum 
◦ ileum

VILLUS/LACTEAL
} MICROVILLI
Term
DIGESTIVE HORMONES
Definition
Gastrin Secretin Cholecystokinin/ CCK
Term
Secretin
Definition
causes the pancreas to send out a digestive juice that is rich in bicarbonate. It stimulates the stomach to produce pepsin, an enzyme that digests protein, and it also stimulates the liver to produce bile.
Term
Gastrin
Definition
causes the stomach to produce an acid for dissolving and digesting some foods. It is also necessary for the normal growth of the lining of the stomach, small intestine, and colon.
Term
Cholecystokinin/ CCK
Definition
causes the pancreas to grow and to produce the enzymes of pancreatic juice, and it causes the gallbladder to empty.
Term
PANCREAS
Definition
} The “double gland”
} Two major functions:
◦ Endocrine - Secrete insulin and glucagon to control blood sugar levels
– Alpha cells secrete glucagon (increase blood sugar)
– Beta cells secrete insulin (decrease blood sugar)
◦ Exocrine – Secrete pancreatic juice (1.5 L/day) to aide in digestion 
– Acinar cells contribute digestive enzymes to the pancreatic juice including:
– Protein-digesting enzymes (a.k.a. proteases).
– Fat-digesting enzymes such as pancreatic lipase.
– Carbohydrate-digesting enzymes such as pancreatic amylase.
– Duct cells secrete a bicarbonate-rich solution to neutralize the acidity of the chyme
Term
PANCREAS
} Largest internal organ/gland in the body 
} Multiple functions
Definition
◦ Carbohydrate metabolism – storage and release of glucose
◦ Removal of drugs, toxins, and foreign chemicals from the plasma
◦ Storage of vitamins (A, D, E, and K) and minerals (iron and copper)
◦ Protein metabolism
◦ Lipid metabolism
◦ Synthesis of plasma proteins (e.g., albumin, fibrin, etc.)
◦ Phagocytosis of old RBCs and of pathogens.
◦ Production of bile (0.5-1 L/day).
Term
LIVER
Definition
GALL BLADDER/BILE
} Bile = bile salts, pigments (e.g., bilirubin) and other chemicals 
} made by liver
} secreted into duodenum 
} Fatty chyme in SI, triggers intestinal glands to secrete cholecystokinin 
} CCK causes the contraction of the gallbladder and bile to be released into the duodenum
Bile salts from liver 
emulsify the fats 
In a larger fat globule
only the surface lipids are exposed
to the enzymes
Lipase from the
pancreatic juice
cleave off fatty acids
Term
LARGE INTESTINE
Definition
Reabsorbtion 
◦ Water
◦ Vitamins – K, biotin, and B5 
◦ Organic wastes 
◦ Bile salts
◦ Toxins
} Defecation 
◦ Mass movements of material through colon and rectum
◦ Defecation reflex triggered by distention of rectal walls
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