Term
| What are the endocrine roles of the liver? |
|
Definition
secretes IGF-1 to amplify effects of growth hormone
involved with Vit D metabolism |
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|
Term
| What is the exocrine role of the liver? |
|
Definition
|
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Term
| What are the 4 lobes of the liver? |
|
Definition
large L & R
smaller quadrate & caudate |
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Term
| How is blood supplied to the liver? |
|
Definition
75% comes from the hepatic portal vein (from gut)
-low in oxygen & nutrients, contains toxins etc
25% from hepatic artery
blood mixes before entering sinusoids |
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|
Term
| Describe the flow of blood through the liver |
|
Definition
1. Hepatic portal vein & hepatic artery
2. Sinusoids
3. Central vein
4. Sublobar vein
5. Hepatic veins
6. Inferior vena cava |
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Term
|
Definition
| parenchymal cells of the liver |
|
|
Term
| What are liver macrophages called? |
|
Definition
|
|
Term
| Where are kupffer cells found? |
|
Definition
|
|
Term
|
Definition
| store Vit A, can cause liver fibrosis if they differentiate into myofibroblasts |
|
|
Term
| What is unique/cool about hepatocytes? |
|
Definition
-polyhedral shape
-multipolar (more than one surface has modifications)
-no true basement mmb |
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|
Term
| Bile produced by hepatocytes is secreted into.... |
|
Definition
|
|
Term
| What are the 3 'sides' of a hepatocyte? |
|
Definition
1. Apical canalicular suface, bordering the bile canaliculi
2. Microvillo at basal surface
3. Lateral contact surface between hepatocytes (junctional proteins) |
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|
Term
| What is the space of Disse? |
|
Definition
-space between hepatocytes & sinusoids
-where blood is exchanged between CV system & sinusoids |
|
|
Term
| Site of blood exchange for hepatocytes |
|
Definition
|
|
Term
| The biliary tree is lined by _________. What do these cells do? |
|
Definition
cholgangiocytes
-monitor & regulate bile production |
|
|
Term
| How does bile flow from the liver to the SI? |
|
Definition
1. Canaliculi
2. Bile ductule
3. Hepatic ducts
4. Common hepatic duct
5. Cystic duct (to gallbladder)
6. Common bile duct (to SI) |
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|
Term
| What defines the margins of a classic lobule? |
|
Definition
| portal triad in each corner, central vein in the middle |
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Term
| When looking at flow within the classic lobule, _____ goes from central to periphery while _____ goes periphery to central |
|
Definition
|
|
Term
| When looking at the portal lobule, ____ goes from central to periphery while ____ goes periphery to central |
|
Definition
|
|
Term
| What defines the margins of a portal lobule? |
|
Definition
| central vein from 3 classic lobules form the corners of a triangle |
|
|
Term
| What is a liver acinus? What are the regions? |
|
Definition
lobule division of the liver.
Zone 1 = centroacinar (most oxygen, most toxins)
Zone 2 = Midzone
Zone 3 = Periacinar (least oxygen & least toxins) |
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|
Term
| What lobule structure is best for emphazising endocrine & anatomy of the liver? |
|
Definition
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|
Term
| What lobule structure is best for emphasizing exocrine function of the liver? |
|
Definition
|
|
Term
| What lobule structure is best for emphasizing metabolic activity & liver pathologies? |
|
Definition
|
|
Term
|
Definition
fenestrations
endothelial cells
space of disse
hepatocyte |
|
|
Term
| components of the portal triad |
|
Definition
arteriole
venule
bile ductule |
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