Shared Flashcard Set

Details

Diabetic Nephropathy
Renal Module
14
Medical
Graduate
05/02/2009

Additional Medical Flashcards

 


 

Cards

Term
What is the leading cause of end stage renal failure in the US?
Definition
diabetic nephropathy
Term
What type of nodules are seen in the LM of a diabetic nephropathy patient?
Definition
Kimmelsteiel Wilson nodules
Term
What is the hemodynamic mechanism that contributes to the diabetic nephropathy?
Definition
vasodilation of the afferent arteriole, which raises the glomerular hydrostatic pressure
Term
What is the metabolic mechanism that contributes to the diabetic nephropathy?
Definition

glycoslation

increase in PKC

 

which increases mesangial matrix and cells

Term
What are the clinical complications of diabetes? (6)
Definition

nephropathy

neuropathy

peripheral vascular disease

retinopathy

dyslipidemia

HTN

Term
What type of diabetes is diabetic nepropathy more common in?
Definition
Type I
Term
What typical presentation of a diabetic patient will lower the chances of you needing to do a renal biopsy?
Definition

long standing DM

proteinuria

benign urine sediment

renal insufficiency

Term
Which stage of diabetes do you see the beginning of the nephropathy? Why?
Definition
stage 3 b/c onset of microalbuminuria
Term
What is true of the GFR in the beginning stages of diabetes?
Definition
it rises initially
Term
Which stage of diabetes is the clinical stage for diabetic nephropathy?
Definition
stage 4
Term
What is the general time frame for progressing through the stages of diabetes toward end stage renal failure?
Definition

stage 1 weeks to months

stage 2 after 2 years

stage 3 10-15 years

stage 4 5-10 after stage 3

stage 5 7 years after stage 4

Term
How often are type I diabetic screened for microalbuminuria?
Definition
after 5 years of disease and every year after
Term
How often are type II diabetics screened for microalbuminuria?
Definition
every year
Term

What BP is the goal for HTN treatment in diabetic patients and renal disease patients in general?

 

What is it for the normal population?

Definition

<130/80

 

 

<140/90

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