• tolbutamide (Orinase): short acting
• acetohexamide (Dymelor): intermediate acting
• chlorpropamide (Diabinese): long acting
• tolazamide (Tolinase): intermediate acting

• Antidiabetics w/ antibacterial activity
• stimulate pancreatic beta cells to secrete more insulin

• glimepride (Amaryl) beta blocker give drug w/ 1st meal of day
• glyburide
• glipizide (Glucotrol, Glucotrol XL)
• directly stimulates beta cells to secrete insulin thus decreasing the blood glucose levels

• stimulates pancreas to secrete insulin (stimulates the beta cells to release insulin)
• affects the hepatic and GI production of glucose
• decrease glucose levels in type 2 diabetes
• take 15 min before meals Eat immediately

• combined with Glucovance
• increases bodies sensitivity to insulin
• proglitazone (Actos)- can be taken in combo w/ sulfonylurea or insulin
• rostiglitazone (Avandia)- may be combined w/ Metformin

• take w/ foods, can cause renal failure
• inhibit production of glucose by liver
• d/c for contrast dye 48 hours before and after or will have kidney failure
• SE: bitter taste, N/V/D, bloating, gas
• Affects absorption of B-12

• Humalog
• Novalog
• Onset 5-15 min
• Peak 1hr
• Duration 1-5 hr
• ** Take w/ food immediately after admin med**

Short Acting Insulin: regular (clear)

• Numalog R
• Novolin R
• Onset: 30-60min
• Peak: 2-4 hr
• Duration: 6-8hr
• Only insulin used in IV
• Give 20-30 min b/f breakfast.
• Check blood sugar @ lunch time 

• Insulin isophane NPH
• Insulin zinc suspension (Humalin L, Novolin L)
• Onset: 1-2 hrs
• Peak: 6-12 hrs
• Duration: 18-24 hrs

• insulin glargine (Lantus)
• Onset: 1hr
• Peak: none
• Duration: 24 hrs

• Humulin 70/30
• NPH 50/50
• Onset: 30 min
• Peak: 4-8 hrs
• Duration: 24 hrs