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Diabetes
Downstate > MS2 Endocrine > Diabetes
23
Medical
Graduate
03/04/2011

Additional Medical Flashcards

 


 

Cards

Term
rank fat, muscle and liver in terms of insulin sensitivity
Definition
fat > liver > muscle
(fat most sensitive)
Term
fat, liver and muscle response to insulin
Definition
fat: inhibit lipolysis
liver: inhibit GNG
muscle: uptake glucose
Term
screening recommendations
Definition
every 3yrs >35yo
every 1yr if risk factors+
Term
normal FPG, 2hPG, and HbA1c
Definition
FPG <100
2hPG <140
A1c < 5.7
Term
pre-diabetic FPG, 2hPG, and HbA1c
Definition
100 < FPG < 126
140 < 2hPG < 200
5.7 < A1c < 6.4
Term
diabetic FPG, 2hPG, and HbA1c
Definition
FPG > 126
2hPG > 200
A1c > 6.4
Term
type 1 DM presentation
Definition
DKA, polyuria, polydypsia, polyphagia, muscle wasting, weight loss
Term
most common cause of death in diabetics
Definition
MI
Term
complications of DM
Definition
retinopathies, renal disease, CAD, peripheral neuropathies
Term
type 1 DM is autoimmune and [cell/antibody] mediated
Definition
cell-mediated
Term
DM type 1 is associated with HLA-___?
Which HLA is protective?
Definition
HLA-DR3 and DR4
DR2 is protective
Term
antibodies in type 1 DM target...
Definition
insulin, ICA, and GAD
Term
definition of DM type 2
Definition
beta cell dysfunction + insulin resistance
Term
metabolic syndrome
Definition
HTN, dyslipidemia, pro-inflammatory, pro-coagulant state, endothelial dysfunction, obesity, insulin resistance
Term
diagnostic criteria for metabolic syndrome
Definition
any 3: waist >40"M or >35"F, LDL >40M or >50F, TAG>150, BP>130/85, FPG>100
Term
35yo thin pt with hx of type 2 DM presents with DKA and is positive for autoantibodies; dx?
Definition
LADA
Term
25yo thin pt with hx of type 2 DM presents with DKA and is negative for autoantibodies; dx?
Definition
MODY
Term
screening recommendations for gestational diabetes?
diagnostic criteria?
Definition
screen during 2nd trimester
dx: 96 < FPG < 126
Term
complications of gestational diabetes
Definition
fetal macrosomia, childhood metabolic syndrome
Term
when does gestational diabetes occur?
Definition
2nd and 3rd trimester
Term
pathogenesis of gestational diabetes?
Definition
HPL, estrogen, and progesterone increase insulin resistance
Term
autosomal dominant, monogenic disease of young adult that present with DKA
Definition
MODY
Term
35yo obese pt with hx of type 2 DM presents with DKA; dx?
Definition
Flatbush diabetes
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