Brand: Glucatrol, Glucatrol XL

Class: Sulfonylurea

Dose:   2.5-40 mg/day

   5-20  mg/day (ER)

Brand: Amaryl

Brand: Diabeta

Brand: Prandin

Class: Meglitinide

Dose: 0.5-4 mg

MDD = 16mg

Recommended start : 0.5-1 mg/day with meals

start with 1-2 mg with meal if A1C > 8%

Do not use with SU

Brand: Starlix

Class: Meglitinide

Dose: 60-120 mg TID with meals

Brand: Glucophage, Riomet

ER: Glucophage XR, Glumetza, Fortamet

Class: Biguinide

give with meals (GI side effects)

Watch out for lactic acidosis

Dose: usually BID or TID

850-1000mg BID

Start at 500mg QD/BID  or 850 mg QD

(titrate every 5-7 days)

MDD= 2500 mg/day

XR dose: usually QD or BID

1000-2000 mg qpm

start at 500 mg 

(titrate every 5-7 days

MDD = 2000 mg/day

Brand: Actos

Class: TZD

Dose: 30-45 mg/day

(initiate 15-30 mg/day)

ADRs:

-edema/fluid retention

-weight gain

-heart failure (do not use in CHF patients)

-liver enzyme abnormalities (do not use in ALT <2.5 ULN)

-fractures

brand: Avandia

Class: TZD

Dose: 4-8 mg/day

(Initiate 2-4 mg/day)

Brand: Precose

class: α-glucosidase inhibitors

dose: 

weight < 60 kg = 50 mg TID

weight > 60 mg = 100 mg TID

DI = antacids, bile acid resins, digestive enzyme preparations

ADR = flatulence/ bloating

Brand: Byetta

Class: GLP-1 Agonist

Dose: 

5mcg SQ BID for 1 month

then 10 mcg SQ BID 

*within 60 min of AM and PM meals*

Brand: Victoza

Dose: 1.8 mg QD 

Start at 0.6 mg x 1 week, then increase by 0.6 mg every week

(not yet approved in US)

Brand: Januvia

Class : DPP IV inhibitors

Dose: 100mg QD

CrCl 30-50 = 50mg QD

CrCl < 30 = 25mg QD

Brand: Galvus

Class : DPP IV inhibitor

Dose: 50mg QD-BID

(in preapproval states)

Brand: Symlin

Class: Amylin Analog

Dose:  

T1= 30-60 mcg SC with meals

T2 = 60-120 mcg SQ with meals

15mcg = 2.5 units