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Developmental Disturbances
Developmental Disturbances
103
Pathology
Professional
02/23/2013

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Term
When does a developmental disorder occur?
Definition
occurs when either failure or a disturbance occurs during cell division and differentiation into various structures of the body
Term
What are inherited disorders caused by? Who are they transmitted to?
Definition
an abnormality in genetic makeup and are transmitted from patent to child
Term
What is a congenital disorder?
Definition
one that is present at birth, could be developmental or inherited
Term
What results in a cleft?
Definition
failure of the palatine processes to fuse with the premaxilla
Term
What plays a role in the development of a cleft?
Definition
heredity and other factors
Term
Is a cleft lip more common in males or females?
Definition
males, 655
Term
is a cleft lip and palate more common in males or females?
Definition
males, 71%
Term
Is a cleft palate alone more common in males or females?
Definition
females, 66%
Term
How many infants born in the US are born with a cleft lip or palate?
Definition
every 1/800
Term
What weeks in utero would a cleft occur?
Definition
at 6-12 weeks
Term
What is an indication of mild clefting?
Definition
a bifed uvula
Term
In a unilateral cleft is left or right cleft more common?
Definition
left
Term
What happens o a bilateral cleft?
Definition
the globular process fails to fuse with the maxillary process
Term
How old does a baby need to be before a repair can be done on a cleft lip?
Definition
about 10 weeks old
Term
How old does a baby need to be before repair can be done on a cleft palate?
Definition
9-18 months
Term
What are some soft tissue abnormalities?
Definition
-lip pits
-double lip
-white sponge nevus(looks like candidiasis but does not wipe off)
Term
What is ankyloglossia?
Definition
extensive adhesion of the tongue to the floor of the mouth
Term
What does ankyloglossia result from?
Definition
a complete or partial fusion of the frenum to the floor of the mouth
Term
What is a common name for ankyloglossia? What can it affect?
Definition
-tongue tied
-can effect speech, cause gingival recession and bone loss
Term
What is macroglossia?
Definition
an enlarged tongue, might see scaloping
Term
What is a bifid tongue an indicator of?
Definition
incomplete fusion
Term
What is another name for median rhomboid glossitis? What is it caused by?
Definition
-central papillary atrophy
-believed to be caused by erythematous candida
Term
What does median rhomboid glossitis cause?
Definition
-appears as a flat or slightly raised oval in the middle of the dorsum of the tongue
-smooth, devoid of filliform papillae
Term
What causes fissured tongue?
Definition
not sure
Term
What is another name for geographic tongue? What does it look like?
Definition
-also called benign migratory glossitis
-erythematous patches with white borders
Term
What is geographic tongue thought to be linked with?
Definition
psoriasis
Term
What is hairy tongue?
Definition
increased keratin on filiform papillae from either an increase in keratin production or decrease in desquamation
Term
What can the papillae become stained with in hairy tongue?
Definition
-food
-drink
-drugs
Term
What is a palatine torus? Where are these found?
Definition
exophytic growth of normal compact bone, midline of the palate
Term
What do palatine torus look like? When do they appear?
Definition
-take various shapes and sizes
-peak incidence shortly before age 30
Term
What is the incidence of palatine torus?
Definition
-20-25% of population has them
-women 2:1
Term
What is a mandibular tori? What shape are they?
Definition
-normal, dense bone
-usually bilateral, often lobulated
Term
Where are mandibular tori usually found?
Definition
linguals of the mandible in the area of the premolars above the mylohyoid ridge
Term
What is exotosis? Where is it found?
Definition
-nodular bony outgrowth of normal, compact bone
-found on buccal of maxillary or mandibular ridges
Term
What is macrognathia?
Definition
an abnormally large jaw
Term
What causes macrognathia?
Definition
could be congenital(class III) or result from disease like Paget's disease or acromegaly
Term
What stages of tooth development can disturbances causes abnormalities?
Definition
any stage
Term
What determines clinical manifestations of a tooth abnormality?
Definition
-the kind of disturbance
-stage the tooth was at during disturbance
-how long it was disturbed
Term
What is anodontia?
Definition
lack of teeth
Term
What is hypodontia?
Definition
lacking or missing one or more teeth
Term
What are the teeth most often missing in hypodontia?
Definition
3rd molars, maxillary laterals, mand 2nd molars
Term
What is supernumerary teeth? What are the most common?
Definition
extra teeth, most common are mesiodens and distomolar
Term
What occurs in Garner's syndrome?
Definition
multiple supernumerary teeth, patient also has colon polyps and cancer
Term
What is microdontia?
Definition
small tooth, most common in a single toooth, peg laterals or 3rd molars
Term
What is gemination?
Definition
one tooth attempts to divide into 2 teeth, one single root and pulp canal
Term
What stage of tooth development does gemination occur? What does it look like?
Definition
-occurs in cap stage
-looks like macrodontia until you do radiographs
Term
What is fusion?
Definition
union of two teeth
Term
What can fusion result in?
Definition
-one large tooth
-union of the crowns only
-union of the roots only
Term
What does true fusion involve?
Definition
fusion of dentin, seperate or fused roots seen
Term
What can you do to tell the difference between fusion and gemination?
Definition
count teeth or take radiographs
Term
What is concrescence?
Definition
a form of fusion in which teeth are united by cementum only
Term
What is dilaceration? what causes it?
Definition
-abnormal curve or angle in the root, -thought to be caused by trauma to the tooth germ during root development
Term
What is an enamel pearl?
Definition
a small, sperhial emamel projection on a root surface
Term
Why do enamel pearls occur?
Definition
as a result of abnormal displacement of ameloblasts
Term
Which teeth are enamel pearls seen in most of the time?
Definition
-multi rooted
-maxillary teeth
Term
What is a talon cusp?
Definition
an accessory cusp located in the cimgulum rea of an incisor
Term
what are talon cusps composed of?
Definition
normal enamel, dental and pulp horn
Term
What is taurodont?
Definition
teeth exhibit elongated large pulp chambers and short roots
Term
What is another name for dens in dente?
Definition
dens invaginatus
Term
What is a dens in dente?
Definition
-enamel organ infolds into the crown
-results in a tooth-like structure within the tooth
Term
What is dens evaginatus?
Definition
accessory enamel cusp found on the occlusal surface
Term
What are supernumerary root?
Definition
extra roots
Term
What is enamel hypoplasia?
Definition
incomplete or defective formation of enamel, less quantity of normal
Term
What does enamel hypoplasia result in?
Definition
alteration of tooth form or color
Term
What is enamel hypoplasia caused by?
Definition
a disturbance of ameloblasts during enamel matrix formation
Term
What are some possible disturbances that can cause enamel hypoplasia?
Definition
-illness with high fever
-vitamin deficiency(A,C,D)
-local infection of deciduous teeth
-tooth much fluoride(Most common)
-congenital syphilis
-birth injury
-ameloblasts imperfecta(only one that is part of genes)
Term
What is "turners tooth" ?
Definition
hypoplasia that occurs because of a local infection of a deciduous teeth affecting permanent tooth below- LOCAL (usually in 1 tooth)
Term
How do you get dentinogenesis imperfecta?
Definition
hereditary
Term
What is the crown and dentin like in dentinogeneis imperfecta?
Definition
-crowns are bulbous with an opalescent brown to blue color
-dentin is soft, so ENAMEL chips off
Term
What are the pulp chambers and roots like in dentinogenesis?
Definition
-NO pulp chambers or root canals
-short roots
Term
What is enamel hypocalcification?
Definition
disturbance of the maturation of enamel
Term
What does enamel hypocalcification look like?
Definition
white chalky, localized spot
Term
What do intrinsic stains of teeth occur from?
Definition
result from circulating elements during tooth development being deposited in the enamel
-elements from pulp leaching through dentin tubules
Term
What does it mean if a tooth is ankylosed?
Definition
it is fused to bone
Term
What does it mean if a tooth is impacted?
Definition
physical obstruction
Term
Why do teeth become embedded?
Definition
because of a lack of erupted forces
Term
What is attrition?
Definition
loss of tooth structure through tooth to tooth friction (grinding teeth)
-can see dentin on occlusal surface
-or the tooth structure changes(like canine point gone)
Term
What is abrasion?
Definition
loss of tooth structure caused by mechanical wear (gums recede and then the tooth gets worn away)
Term
What is abfraction?
Definition
loss of tooth structure at the CEJ caused by abnormal occlusal forces
Term
What is erosion?
Definition
loss of tooth structure caused by acidic chemicals in prolonged contact with the teeth
Term
What is a karyotype?
Definition
a picture of the collection of one's 46 chromosomes
Term
What is a genotype?
Definition
one's genetic makeup
Term
What is a phenotype?
Definition
how one's genes are expressed
Term
What are some patterns of inheritance? (4)
Definition
1.autosomal dominant
2.autosomal recessive
3.X-linked dominant
4.X-liked recessive
Term
What is the difference between enamel hypocalcification and enamel hypoplasia?
Definition
enamel hypoplasa- happens when ameloblasts are making enamel
enamel hypocalcifiction- happens during enamel maturation(it does not occur)
Term
Where do molecular abnormalities occur? WHat kind of disorders are they?
Definition
at DNA level, inherited disorders
Term
What are some examples of molecular abnormalities?
Definition
they can be as common as palatine torus or very rare conditions
Term
Why do gross abnormalities occur?
Definition
because of an alteration in chromosome number or alteration in structure
Term
How many chromosomes are effected in gross abnormalities?
Definition
this can range anywhere a complete 2nd set of chromosome (92) total to loss of part of a chromosome
Term
What is the name for the gross abnormality, Trisomy 21?
Definition
downs syndrome
Term
What is the most frequent of the trisomes?
Definition
Trisomy 21(Down's syndrome)
Term
What are the characteristics of down's syndrome?
Definition
-slanted eyes
-heart abnormalities
-lower inteligence level
-hypodontia
-fissured tongue
-abnormalitis in shape, position, and eruption of teeth
Term
What does trisomy 13?
Definition
A gross abnormality
Term
What are the characteristics of trisomy 13?
Definition
-cleft lip and palate
-small or no eyes
-mental retardation
-heart malformations
Term
What is turner's syndrome caused by?
Definition
female phenotype, only 1 X instead of 2 X's
Term
What happens in turners syndrome?
Definition
ovaries do not develop along with other physical abnormalities
Term
What are some examples of molecular chromosomal abnormalities?
Definition
-Cyclic neutrophils
-papillon-FeFecre syndrome
Term
What are cylic neutrophils?
Definition
periodic decrease in neutrophils
Term
What is papillon-lefarve syndrome?
Definition
marked destruction of periodontal tissues, premature loss of teeth, and hyperkeratosis of the palms and soles
Term
What are some other abnormalities?
Definition
-cherubism
-cleidocranial
-garner syndrome
Term
What is cherubism?
Definition
progressive bilateral facial swelling before 4 years of age
-soap bubble appearance of the jaws
Term
What is cleidocranial dysplasia?
Definition
MANY supernumary teeth
Term
What is Garner syndrome?
Definition
-osteomas in maxilla and mandible
-multpiple odontomas
-intestinal polyps
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