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Dermatology: Palpulosquamous and Inflammatory
Papulosquamous and Inflammatory Dermatoses
19
Medical
Graduate
09/14/2010

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Term
Keratosis Pilaris
Definition
Keratinization of hair follicles of the skin. Common in young women. Small, rough folliculocentric keratotic erythematous papules. Common on posterolateral upper arms, thighs, face and buttocks. Spares palms and soles. Asymptomatic.
Term
Xerosis
Definition
"Dry skin" Basis for various patterns of Atopic Dermatitis. May itch which can lead to rash from scratching. Most common on extensor surfaces.
Term
Ichthyosis Vulgaris
Definition
Alteration in epidermal cell proliferation. Dry, rectangular scales. Commonly hereditary. Onset within first year of life. Fine, white, adherent polygonal scale with central tacking. Extensor extremities.
Term
Psoriasis
Definition
Common, chronic inflammatory disease that affects the skin, nails and joints. Relentless waxing and waning. Proliferation of outer layers of skin due to abnormal T lymphocytes. Sharply marginated, silvery-white scale. Common on extensor surfaces such as elbows, knees and scalp.
Term
Common Plaque Psoriasis
Definition
Most common form of psoriasis.
Term
Guttate Psoriasis
Definition
Preceded by Strep pharyngitis. Small, scaly papules. Trunk and extremities. Spares palms and soles. From of psoriasis.
Term
Inverse Psoriasis
Definition
Psoriasis found under breasts, in armpit and other areas where skin touches skin. Can be confused with yeast infection.
Term
Erythrodermic Psoriasis
Definition
Generalized and emergent psoriasis. Total body redness. Uncommon.
Term
Pityriasis Rosea
Definition
Acute, self-limiting infection. Primary plaque is generally on the trunk and resembles ringworm (Herald Patch). A generalized rash appears 1-2 weeks later that is salmon-pink macules or patches on the lower abdomen. These are in a Christmas Tree distribution and have collarette scale.
Term
Lichen Planus
Definition
Found on flexor surfaces of wrists, forearms and legs just above the ankles. 5 P's (pruritic, planar, polyangular, purple, papules). Wickham striae (white, lacy reticular pattern of criss-crossed lines). Common in adult females.
Term
Papular, hypertrophic, follicular, mucosal, nail.
Definition
Five types of Lichen Planus are _____.
Term
Granuloma Annulare
Definition
Firm, skin colored to erythematous papules. Central depression that is slightly hypo or hyperpigmented. Smoothing, nonscaling, asymptomatic. Looks like tinea, asssociated with diabetes.
Term
Urticaria
Definition
Reactive inflammation. Mast cells release histamine which increases vascular permeability and causes tissue edema. H1 receptors are involved with respiratory and H2 are involved with GI. Raised, red transitory area of edema. Any single lesion should last less than 24 hrs.
Term
Angioedema
Definition
Abrupt and evanescent swellling of skin, mucous membranes, resp/GI tracts. Common in females. Deeper tissue and more diffuse than hives. Non-pitting, swelling. Periorbital or perioral swelling.
Term
Erythema Multiforme
Definition
Commmon, hypersensitivity. Minor: localized, mild or no mucosal involvement. Major: more severe, muscosal and skin; potentially life threatening. Prodrome: URI. Primary lesion: targetoid. Nikolsky sign where top layer of skin looks as if it could peel off. Extensor surface of extremities. Can be on palms and soles. Associated with HSV.
Term
Erythema Nodulosum
Definition
Hypersesitivity. Inflammatory. 18-34 females. Associated with strep infections. Prodrome: URI, arthralgias. Primary lesion: poorly defined, red, firm, tender, bilateral pretibial surfaces. Secondary lesion is fluctuant, bluish or yellow and bruise-like. Hilar lymph nodes involved.
Term
Toxic Epidermal Necrolysis
Definition
Rare, life-threatening mucocutaneous disease. Widespread blistering and sloughing of skin. Usually due to drug reaction (sulfonamides, vaccinations, NSAIDS, allopurinol). Common with HIV and lupus. Initially "sunburn like" with scattered targetoid lesions and bullae. Preceded by fever, malaise, cough and abdominal pain. Greater than 30% TBSA affected.
Term
Stevens-Johnson Syndrome
Definition
Severe blistering mucocutaneous syndrome involving at least two membranes. Common in children and young adults. Cytotoxic immune response to drug. Common with HIV and lupus. Erythematous papules, dusky appearing vesicles, purpura, target lesions. Skin tenderness and burning. Oral, genital, perianal mucosa. Thick hemorrhagic crusts cover lips. Mostly on trunk and face. Less than 10% TBSA affected.
Term
Staphylococcal Scalded Skin Syndrome
Definition
Exfoliation of the skin at the granular layer caused by the endotoxins of Staph aureus. No necrosis of epidermis. Not caused by meds. Most common in neonates and young children. Begins with fever and skin tenderness. Erythema of neck, groin and axillae.
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