Term
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Definition
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Term
| IL-1 mediates ________ immunity |
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Definition
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Term
| IL-1 stimulates what four processes? |
|
Definition
--Endothelial cell adhesion molecules
--Chemokine production by ECs and macrophages
--Synthesis of acute-phase reactants by the liver
--Fever (prostaglandin formation in hypothalamus)
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Term
|
Definition
| antigen activated T cells |
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Term
| IL-2 has what two autocrine functions? |
|
Definition
--Stimulates effector T cell proliferation
--T cell growth and survival
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Term
| IL-2 stimulates proliferation of what two cell types? |
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Definition
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Term
| IL-4 is produced by what two cell types? |
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Definition
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Term
| IL-4 induces differentiation of ______ cells from _______ cells |
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Definition
IL-4 induces differentiation of Th2 cells from CD4+ cells
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Term
| IL-4 stimulates production of what from B cells |
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Definition
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Term
|
Definition
| IFN-gamma mediated macrophage function |
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Term
IL-4 is created in response to
|
|
Definition
helminthic infections
allergens |
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Term
| IL-5 is produced by ______ cells and _______ cells |
|
Definition
Th2 CD4+ cells
activated mast cells |
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|
Term
| IL-5 stimulates growth and differentiation of |
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Definition
|
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Term
|
Definition
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Term
| IL-5 is created in response to |
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Definition
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|
Term
| IL-10 downregulates ____________ cell response |
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Definition
|
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Term
|
Definition
|
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Term
| IFN-gamma is produced by what three cell types? |
|
Definition
T cells (Th1 and CTLs)
NK cells |
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Term
|
Definition
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Term
| IFN-gamma is produced in response to |
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Definition
|
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Term
|
Definition
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Term
| The activation of macrophages by IFN-gamma is used in both ________ and __________ responses, and this allows for macrophages to kill ____________ |
|
Definition
innate and adaptive
phagocytosed microbes |
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Term
| IFN-gamma is crucial in _________ immunity |
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Definition
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Term
| TNF is produced by activated |
|
Definition
|
|
Term
| TNF stimulates ________ and ___________ recruitment |
|
Definition
| neutrophil and moncyte recruitment |
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|
Term
| TNF stimulates expression of ___________ molecules on ________ ECs |
|
Definition
adhesion molecules
vascular ECs |
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|
Term
| TNF stimulates secretion of chemokines by _______ and _________ |
|
Definition
|
|
Term
When present in low quantities, TNF is responsible for
|
|
Definition
| local inflammation and leukocyte recruitment to site of injury |
|
|
Term
When present in moderate quantities, TNF is responsible for
|
|
Definition
systemic effects
prostaglandin-induced fever |
|
|
Term
| What are the three steps in prostaglandin-induced fever? |
|
Definition
--PGs from the hypothalamus
--Liver manufactures acute phase reactants
--Bone marrow generates more neutrophils |
|
|
Term
When present in high quantities, TNF is responsible for
|
|
Definition
--Cachexia, shock --> low cardiac output
--Thrombus formation (prevent neoplasms)
--Hypoglycemia
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|
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Term
| IL-12 is produced by ________ and ___________ cells |
|
Definition
| mononuclear phagocytes and dendritic cells |
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Term
| IL-12 mediates _______ response to ____________ microbes |
|
Definition
|
|
Term
| IL-12 is the key inducer of the _____________ immune response |
|
Definition
|
|
Term
| IL-12 is the key link between |
|
Definition
| innate and adaptive response |
|
|
Term
| IL-12 stimulates IFN-gamma production by what three cell types? |
|
Definition
--Th1 CD4 cells --> promotes Th1 formation from naive CD4 cells
--NK cells
--CTLs |
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|
Term
IL-12 increases ___________ activity by CTLs and NK cells
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|
Definition
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|
Term
| IL-12 inhibits ________ cells |
|
Definition
|
|
Term
|
Definition
| leukocyte movement/migration |
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|
Term
| The CXC family of chemokines is involved in |
|
Definition
|
|
Term
| The CC family of chemokines is involved in recruitment of what four cell types? |
|
Definition
--monocytes
--lymphocytes
--eosinophils
--basophils |
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