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Cytokines
Immunology
27
Biology
Graduate
10/16/2011

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Cards

Term
Th1 cells
Definition

Activate infected macrophages

Provide help to B cells for Ab production

Term
Th2 cells
Definition
Provide help to B cells for Ab production, especially switching to IgE
Term
Th17 cells
Definition

Enhance neutrophil response

Promote barrier integrity (skin, intestine)

Term
TFH cells
Definition

B cell help isotype switching

Ab production

Term
Treg cells
Definition
Suppress T cell responses
Term
Th1 cytokines
Definition
IL-2, IFN-g, LT (TNF-b, LT)
Term
Th2 cytokines
Definition
IL 4, 5, 10, 13
Term
Treg cytokines
Definition
TGF-b
Term
Th17 cytokines
Definition
IL-17
Term
IL-2
Definition
T cell: growth
Term
IFN-g
Definition
Macrophages: activate, increase MHC I and II
Term
LT (lymphotoxin)
Definition
Macrophages: activation, induce NO production (increased phagocytic capacity)
Term
IL-4
Definition

B cells: activation, growth, IgG1 and IgE, increase MHC II

T cells: growth, survival

Term
IL-5
Definition
Eosinophil: growth and differentiation
Term
IL-10
Definition

B cells: increases MHC II

T cells: inhibitory cytokine, inhibits Th1 differentiation

 

Term
TGF-b
Definition

Macrophages/dendritic cells: inhibits activation

Turns off immune response

Term
IL-17
Definition

Neutrophils: stimulates recruitment

Other somatic cells: stimulates fibroblasts and epithelial cells to secrete chemokines (attracts more neutrophils and macrophages, enhances inflammatory response)

Term
IL-1
Definition

Causes fever, acute inflammation

Activates endothelium to express adhesion molecules; induces chemokine secretion to recruit leukocytes

Term
IL-6
Definition
Causes fever, secreted by helper T cells
Term
IL-8
Definition
Major chemotactic factor for neutrophils
Term
IL-13
Definition

Produced by Th2

Helps with IgE production

Term
IL-4 and antibody production
Definition

induces: IgG1, IgE

inhibits other antibodies from forming

released from Th2

Term
IL-5 and antibody production
Definition

augments IgA production

inhibits the other antibodies from forming

released from Th2

Term
IFN-g and antibody production
Definition

induces IgG3, IgG2a

inhibits the others from forming

released from Th1

Term
TGF-b and antibody production
Definition

induces IgG2b, IgA

inhibits the others from forming

released from Th1

Term
CD19+
Definition
B cells
Term
CD14
Definition
Binds LPS
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