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Cytokines
USMLE Review
12
Physiology
Graduate
01/21/2010

Additional Physiology Flashcards

 


 

Cards

Term
PDGF
- cell or origin and function
Definition
origin: platelets, macrophages, endothelial cells
function: cell chemotaxis, mitogenic for fibroblasts, stimulate angiogenesis, stimulate wound contraction
Term
TGF-alpha
Definition
origin: macrophages, Tcells, keratinocytes
function: mitogenic for keratinocytes and fibroblasts, stimulate keratinocyte migration
Term
TGF - Beta
Definition
origin: platelets, T cells, macrophages, endothelial cells, keratinocytes
function: cell chemotaxis to stimulate angiogenesis and fibroblasts to make collagen
Term
EGF
Definition
origin: platelets, macrophages
function: mitogenic for keratinocytes and fibroblasts, stimulates keratinocyte migration
Term
thromboxane A2
Definition
origin: destroyed wound cells
function: vasoconstrictor
Term
interferons (INF_aplha, beta, delta)
Definition
origin: lymphocytes, fibroblasts
function: activate macrophages, inhibit fibroblast proliferation
Term
IL-1
Definition
origin: macrophages, mast cells, keratinocytes, lymphocytes
functionL induce fever and adrenocorticotrophic hormone release, enhances TNF-alpha, IFN-gamma, activated granulocytes and endothelial cells, stimulates hematopoiesis
Term
IL-2
Definition
origin: macrophages, mast cells, keratinocytes, lymphocytes
function: activates macrophages, T cells, NK cells, and lymphokine activated killer cells, stimulates differentiation of activated B cells, stimualtes proliferation of activated B and T cells, induced fever
Term
IL-8
Definition
origin: macrophages, mast cells, keratinocytes, lymphocytes
function: enchances neutrophil adherences, chemotaxis, and granule release
Term
TNF
Definition
origin: macrophages, mast cells, T cells
functionL activates macrophages, mitogenic for fibroblasts, stimulate angiogenesis
Term
KGF
Definition
origin: fibroblasts
function: stimulates keratinocyte migration, differentiation andn proliferation
Term
FGF
Definition
origin: macrophages, mast cells, T cells, endothelial cells
function: chemotactic and mitogenic for fibroblasts and keratinocytes, stimualtes angiogenesis
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