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CYPs and Drug Transporters
Flashcards for some drugs that are substrates of some CYPs and Drug Transporters
21
Pharmacology
Professional
10/23/2011

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Cards

Term
3A5
Definition
Tacrolimus
Term
1A2
Definition
Caffeine, Theophylline, Clozapine
Term
2B6
Definition
Bupropion, Efivirenz, Cyclophosphamide, Ifosfamide
Term
2C9
Definition
Warfarin, NSAIDs, Phenytoin, Losartan
Term
2C19
Definition
PPIs, Citalopram, Phenytoin, Clopidogrel, Escitalopram, Voriconazole
Term
2D6
Definition
BBs, antipsychotics, antidepressants, codeine, tamoxifen, atamoxitine
Term
2E1
Definition
Acetaminophen, Ethanol, halogenated anesthetics
Term
Amplichip
Definition
2D6, 2C19
Term
NAT1
Definition
P-amino benzoic acid, P-amino salicyclic acid
Term
NAT2
Definition
Isonaizid, Dapsone, Sulfonamides
Term
UGT1
Definition
Irinotecan
Term
UGT2
Definition
Bilirubin
Term
GSTP1
Definition
Etoposide, doxyrubicin, cysplatin, oxaloplatin, carboplatin
Term
GST (general)
Definition
Oxidative products (polymorphisms yeild higher cancer risk)
Term
GSTP1 (in children)
Definition
Acetaminophen
Term
ABCB1 (MDR1)
Definition
Digoxin, Cyclosporin, Anti-epileptics,
Term
ABCB2 (MRP2)
Definition
Dubin-Jonhson Syndrome (increased bilirubin) methotrexate
Term
SERT (SLC6A4)
Definition
SSRIs
Term
SLC19A1 (RFC1)
Definition
Folate and antifolate drugs including methotrexate
Term
OATB1P1
Definition
Statins
Term
OCT1
Definition
Metformin
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