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Details

C. Smith- STDs
STDs
50
Pathology
Graduate
10/24/2009

Additional Pathology Flashcards

 


 

Cards

Term
non viral STDs
Definition

Chlamydia

Gonorrhea

Syphillis

Trichomoniasis

Term
Viral STDs
Definition

HPV

Herpes

Hep B

HIV

Term
Uncommon STDs
Definition

Chancroid

Lumphogranuloma venereum

Granuloma inguinale

Pubic Lice

Term
What breaks in mucosal surface of oropharynx or genitals, can spread to sensory neurons, can be latent in neuronal cell bodies?
Definition
Herpes simplex
Term
What can trigger Herpes to move from neurons to the skin?
Definition

stress

sunlight

immunosurpression

Term
How is HSV 1 transmitted?
Definition

mostly nonvenereal ways

 

-presents with mucosal infection, cold sore (fever blister)

Term
How is HSV transmitted?
Definition
sexually
Term
How long does it take for Herpes lesions to show?
Definition

3 -7 days

 

(3-21 day incubation period)

Term

local pain

tenderness

itching

red papules, vesicles, ulcers

Definition

Herpes simplex

symptoms

Term
How do you detect HSV-2?
Definition

microscope of scrapings

Western blot/ Immunoblot enzyme assay

assay looks at antibodies

Term
What is a Tzanck smear?
Definition

smear of Herpes lesion

-viral inclusions, glassy nucleus, multinucleate cell

Term
What disease involves the spirochete, Treponmea pallidum?
Definition
Syphilis
Term
How can Syphilis be visualized?
Definition

silver stain

dark field

IF technique

Term
What are the phases of Syphilis?
Definition

primary

secondonary

latent

tertiary

Term
What does the primary stage of syphilis look like?
Definition
sore (chancre)
Term
What is the average incubation for syphilis?
Definition
21 days
Term
What do you see in secondary syphilis?
Definition

skin rash

mucous membrane lesions

non-pruitic

palms and soles affected

fever

condyloma lata

pathcy alopecia

Term

 What is 

 

condylomata lata?

 


Definition

white lesions associated with

 

secondary syphilis

Term
What are characteristics of latent syphilis?
Definition

asymptomatic

organisms enter the viscera (CNS, aortic wall)

syphilitic aortitis

paresis

neurosyphilis

gumma

Term
How do you diagnose Syphilis?
Definition

clinical presentation

darkfield

serologic 

(RPR/VDRL/STS)

treponemal Ab

(FTS-Abs and MHATP)

Term
What cell infiltrate is characteristic of syphilis?
Definition

plasma cell

 

around vessels

Term
What does tertiary syphilis morphology look like?
Definition

1. aoritis/scared media/no elasticity/ aortic dilation

2. thick meninges/paresis/neural loss/iron deposits/ tabes dorsalis/posterior column loss (pain/position)/ charcot joint

3. gumma 

Term
What is a gumma?
Definition
a rubbery mass with necrosis in the middle with macrophages, fibroblasts, lymphocytes, plasma cells around it
Term
what less common ulcerative lesion like a chancroid is caused by?
Definition
Hemophilus ducreyi
Term

What is characteristic lesion Hemophilus ducreyi?

Definition
soft chancre, that begins as a small inflammatory papule, painful, inguinal lymph nodes would be tender, no induration of ulcer margins
Term
What is Lymphogranuloma venereum caused by?
Definition
Chlamydia trachomatis (L1-L3)
Term
Lymphogranuloma venereum lesions look like what?
Definition
lesions start as transient papule, then ulcer, then heals
Term
Lymphogranuloma venereum effects are?
Definition

inguinal lymphadenopathy

abscess and fistulae

Poupart's ligament get groove sign

rectal and urethral strictures

Term
What does Klebsiella granulomatis cause?
Definition
Granuloma inguinale
Term

Granuloma inguinale is characterized by?

 

Definition

irregular ulcers

rolled margin

erythematous

cobblestone base

large lymph 

Term

Granuloma inguinale histology looks like?

Definition

mononuclear cells with intra-cytoplasmic vacuoles containing bacteria

(Donovan bodies)

Term
What STD is characterized by urethritis and/or cervicitis?
Definition

Gonorrhea

(Niesseria gonorrhoeae)

gram -

Term
What does Gonorrhea cause in women?
Definition

A WHOLE LOT OF INFLAMMATION

periurethritis

cervicitis

endometritis

salpingitis(fallopian Tube inflammation)

tuboovarian abscess

Fitz-Hugh-Curtis syndrome

endocarditis

arthritis

skin rash

Term
Chlamydia trachomatis causes?
Definition
Chlamydia
Term

T/F 

Chlamydia is commonly asymptomatic?

Definition
true
Term
Chlamydia causes what in males and females?
Definition

males-urethritis

 

women-cervicitis

Term
Chlamydia transmitted via the birth canal can result in?
Definition

neonatal conjunctivitis

pneumonia

Term

Chlamydia 

in

Men

Definition

inflammation in the genitals

rectum (procitis)

throat

eye

Reiter's syndrome (systemic)

 

Term

Chlamydia 

in

Women

Definition

inflammation in 

genitals

eye

throat

rectum

Term

Chlamydia 

in

infants

Definition

conjuctivitis

 

pnuemonia

Term

T/F

Chlamydia in Women can not cause infertility

Definition
False
Term
How can Chlamydia be diagnosed?
Definition

ELISA

DNA amplification

Flourescent antibody test

Pap smear

Term
Human papillomavirus causes what?
Definition

genital warts

genital carcinomas

Term
Trichomonas vaginalis causes what?
Definition
Trichomoniasis
Term

T/F

Trichomonas is asymptomatic in men usually?

Definition
true
Term
What are the symptoms in Trichomonas that occur in women?
Definition

malodorous, yellow/green discharge

vulvovaginal irritation

dysuria

dyspareunia

Strawberry change

Term
How is Trichomonas diagnosed?
Definition
culture
Term
Hep A and B have been on the rise in what population?
Definition
Men who have sex with Men
Term
Proctitis results from which bugs?
Definition

HSV

gonococcus

chlamydia

T. Pallidum

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