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Covenant Bio 346 Chapter 1
Cancer biology
14
Biology
Undergraduate 2
05/07/2012

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Term
Hypertrophy
Definition
tissue growth based on an increase in cell size
Term
Dysplasia
Definition
abnormal tissue growth in which the cell and tissue organization is disrupted; may be an early stage in cancer development.
Term
neoplasm
Definition
growing mass of tissue created by an abnormal process in which cells proliferate in an uncontrolled, relatively autonomous fashion, leading to a continual increase in the number of dividing cells; may be either benign or malignant; aka tumor.
Term
basal cell
Definition
relatively undifferentiated type of epithelial cell whose proliferation gives rise to cells that are more specialized; division of basal cells in the skin produces more basal cells plus cells that migrate toward the outer layer of the skin, gradually differentiating into flattened squamous cells.
Term
benign tumor
Definition
tumor that grows only locally, unable to invade neighboring tissues or spread to other parts of the body.
Term
metastasis
Definition
spread of tumor cells from one part of the body to another via the bloodstream or other body fluids.
Term
carcinoma
Definition
a malignant tumor (cancer) arising from the epithelial cells that cover external and internal body surfaces.
Term
sacroma
Definition
any cancer arising from a supporting tissue, such as bone, cartilage, fat, connective tissue, or muscle.
Term
leukemia
Definition
cancer of blood or lymphatic origin in which the cancer cells reside mainly in the bloodstream rather than growing as solid masses of tissue.
Term
five-year survival rate
Definition
percentage of people who are still alive five years after diagnosis of a disease.
Term
polyp
Definition
any mass of tissue that arises from the wall of a hollow organ and protrudes into the lumen.
Term
pathologist
Definition
doctor who specializes in diagnosing disease by examining tissues and cells with a microscope.
Term
tumor grading
Definition
assignment of numerical grades to tumors based on differences in their microscopic appearance; higher grade cancers tend to grow and spread more aggressively and be less respnsive to therapy than lower-grade cancers.
Term
tumor staging
Definition
estimate of how far cancer has progressed based on a tumor's size and extent of spread at the time of diagnosis. (see TNM system).
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