Term
| Coronoviridae Characteristics |
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Definition
enveloped, acid stable, ssRNA, positive sense
short incubation period
corona=crown (S-proteins) |
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Term
| Coronoviridae Entry, Replication, Exit |
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Definition
fusion or receptor mediated endocytosis
replicates in cytoplasm and accumulates in cisternae of ER and Golgi
release by exocytosis and synctia formation |
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Term
|
Definition
respiratory epithelium
direct invasion of GI epithelium
CNS via nerve tract migration |
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Term
| Coronoviridae Transmission |
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Definition
respiratory aerosols
orofecal route |
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Term
| Feline Enteric Coronavirus Signs |
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Definition
mild to severe diarrhea in kittens
low mortality |
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Term
| Feline Enteric Coronavirus Characteristics |
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Definition
can shed virus in feces for up to 4 months
some cats may be persistently infected |
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Term
| Feline Enteric Coronavirus Control |
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Definition
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Term
| Feline Infectious Peritonitis Characteristics |
|
Definition
phenotypic variant of feline corona virus
persistent FCoV infection mutates into FIPV form
replicates in monocytes/macrophages to become systemic |
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Term
| Feline Infectious Peritonitis Signs |
|
Definition
chronic febrile wasting disease in all ages
immune complex disease but not immunosuppressive
Wet form-peritoneal and pleural effusion, death within weeks to months
Dry form-pyogranuloma and necrosis of multiple organs, may become effusive in terminal stages |
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Term
| Feline Infectious Peritonitis Tropism |
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Definition
respiratory epithelium and enterocytes
macrophages/monocytes |
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Term
| Feline Infectious Peritonitis Pathogenesis |
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Definition
disease enhanced by anti-FCoV antibodies
FCoV sero-negative cats are less likely to progress to FIP cats
FCoV sero-positive cats are more likely to progress to FIP cats
this is a type III immune response
genetics of the cat determines the outcome of infection
If cat has a strong CMI response, it is protected
If cat has a strong humoral response, it shows clinical signs |
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Term
| Feline Infectious Peritonitis Wet Form |
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Definition
strong humoral immune response, weak CMI response
type III hypersensitivity
complement and macrphages activated
macrophages secrete TNF and IL1 to increase vascular permeability
PMNs and fibrinogen emigrate
PMNs degranulate and macrophages secrete nitric oxide
causes tissue damage, vasculitis, organ damage, serosal fibrin deposition
peritoneal and pleural effusion
death within week to months |
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Term
| Feline Infectious Peritonitis Dry Form |
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Definition
partial humoral response, partial CMI response
fever, weight loss, lethargy, icterus
lesion due to viral persistence in macrophages
Type IV hypersensitivity
may become effusive FIP in terminal stages |
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Term
| Feline Infectious Peritonitis Control |
|
Definition
segregate clinically ill animals
vaccinate
sanitation |
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Term
| Feline Infectious Peritonitis Diagnosis |
|
Definition
anti-FCoV and anti-FIPV antibodies are indistinguishable
anti-FIPV antibody titers may decrease in terminal stages of disease
kittens may have maternal ABs
surgical biopsy/necropsy is best way |
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Term
| Transmissible Gastroenteritis Virus Signs |
|
Definition
high mortality in young piglets
seasonal |
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Term
| Transmissible Gastroenteritis Control |
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Definition
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Term
|
Definition
| acute and self-limiting neonatal diarrhea |
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Term
| Bovine Coronavirus Control |
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Definition
| vaccinate neonate and dam |
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Term
| Avian Infectious Bronchitis Virus Signs |
|
Definition
gasping disease
25-75% mortality
decreased egg production
acute,severe respiratory disease involving trachea causing birds to gasp for breath |
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Term
| Avian Infectious Bronchitis Virus Transmission |
|
Definition
highly contagious
respiratory
orofecal |
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Term
| Avian Infectious Bronchitis Virus Control |
|
Definition
difficult due to persistent infection
vaccinate tailor-made vaccine due to different serotypes
sanitation |
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