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Contraception
Overview
25
Physiology
Kindergarten
03/29/2013

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Term
suppress FSH and LH and prevent the follicle development
Definition
estrogen
Term
suppress LH hormone release, thickens cervical mucus, creates atrophied endometrium; alters fallopian tube secretions and inhibit penetration of ovum by sperm
Definition
Progesterone
Term
Semi synthetic estrogens
Definition
mestranol, ethinyl estradiol, estradiol valerate
Term
converted to ethyinyl estradiol in liver; its potency is less than ethinyl estradiol
Definition
Mestranol
Term
most common in combined oral contraceptives
Definition
ethinyl estradiol
Term
progesterone
Definition
medroxyprogesterone, megestrol acetate
Term
testosterone (nortestosterone)
Definition
binds ot progestin and androgen receptors; most BCP progestins
Term
Spironolactone
Definition
anti-aldosterone action, anti-androgenic activity is similar to progesterone (Yaz, Yasmin)
Term
1st generation progestins
Definition
norethindrone, norethynodrel
Term
considered gold standard,most common progestine; ortho-novum, norinyl, ovcon
Definition
Norethindrone
Term
no androgenic activity, not currently on US market
Definition
norethynodrel
Term
3rd generation progestins
Definition
norgestrel, levonorgestrel
Term
4th generation progestin
Definition
desogestrel, norgestimate
Term
can cause potassium retention, not likely to cause cyclic water retention (diuretic effect)
Definition
Drospirenone
Term
side effects to too much include nausea, increased breast size, thromboembolic complications, HTN, decreased libido, increased cholesterol in bile
Definition
Estrogen
Term
side effects from too much include acne, depression, fatigue
Definition
progestin
Term
side effects from a deficiency: atrophic vaginitis, continuous bleeding, early or mid-cycle spotting, hypomenorrhea, vasomotor symptoms
Definition
Estrogen
Term
side effects from a deficiency include dysmenorrhea, hypermenorrhea, late cycle spotting
Definition
Progestin
Term
side effects from deficiency include depression, fatigue, tiredness, acne, oily skin, increased LDL levels, decreased HDL levels, Diabetogen effect
Definition
Androgenic
Term
SEs include breast tenderness, headaches, hypertension, cyclic weight gain secondary to fluid retention
Definition
estrogen and progestin
Term
causes increased OC efficacy
Definition
ascorbic acid, APAP, atorvastatin, Rosuvastatin; NNRTIs, Protease inhibitors
Term
decreased OC efficacy
Definition
anticonvulsants, ABX, Rifampin, Theophyllin, St. John's Wort, Sulfonamides, Griseofulvin
Term
OCs increased the effectiveness of these
Definition
xanyx, Librium, diazepam, theophylline/caffeine, cyclosporine, corticosteroids, alcohol, BB, TCA, Ropinirole, Zolmitriptan
Term
OCs decreased the effectiveness of these
Definition
Temazepam, Warfarin, THyroid agents, hypoglycemic , methyldopa, metformin, amprenavir
Term
flexible inplant inserted into skin of inner upper arm, Etonorgestrel progestin
Definition
Inplanon
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