Shared Flashcard Set

Details

Connective Tissue Disorders
MS Module
35
Medical
Graduate
05/26/2009

Additional Medical Flashcards

 


 

Cards

Term
What is the most common connective tissue disease?
Definition
systemic lupus erythematosus
Term
What is the second most common connective tissue disease?
Definition
Sjogren's
Term
What disease has ANA?
Definition
Lupus
Term
What three general factors determine lupus?
Definition

genetic

enviornmental

immunologic

Term
What type of hypersensitivity is lupus?
Definition
type III (complex)
Term
What are the four most common causes of death in a lupus patient?
Definition

Renal Failure

Infection

CNS complications

Coronary artery disease

Term
What occurs to the small vessels in lupus?
Definition
vasculitis
Term
What disease presents with palpable purpura and why?
Definition
Lupus due to the small vessel vasculitis
Term
What characteristic finding of lupus is sensitive to light?
Definition
malar rash
Term
What is the difference between the joint disease of lupus and rheumatoid arthritis?
Definition

RA is destructive synovitis

Lupus in non-destructive

Term
What does the synovitis in lupus cause?
Definition
polyarthraligias
Term
What is the most common manifestation of lupus?
Definition
symmetric polyarthralgias
Term
What disease presents with serous membrane inflammation?  What are the common sites?
Definition

Lupus

 

Pericarditis

Pleuritis

Peritonitis

Term
Why do lupus patients have an increase risk of Coronary Artery Disease?
Definition
b/c they have accelerated artherosclerosis
Term

What disease presents with antiphospholipid antibody syndrome and what does it cause?

 

What disease does this make this disease often get confused with?

Definition

Lupus


Anitphospholipid antibody syndrome causes and increase in coagulation

 

Syphilis

Term
What are the most diagnositic tests for lupus? (2)
Definition

dsDNA

Smith antigen (small nuclear ribonucleoprotien)

Term
45 y/o Female presents with arthralgia in both knees.  She has also noticed a rash under her eyes.  In addition, she notes that when she is in the sun, this rash often is painful.  What is the most likely diagnosis?  What tests would you want to order?
Definition

Systemic Lupus erythematosus

 

 

order smith antigen and dsDNA test

Term
What disease presents with scaring of the skin and organs due to narrowing of vessels?
Definition
systemic sclerosis (scleroderma)
Term
What are the two categories of scleroderma? What are the general characterisitics of both?
Definition

diffuse: rapid progression, generalized skin lesions, organ involvement

 

limited- less skin involved, slower progression, CREST

Term
What does CREST stand for?
Definition

Calcinosis of skin

Reynauds phenomenum

Esophageal dysfunction(dysphagia, large diverticuli)

Sclerodactyl

Telengiectasia

 

Term
What disease presents with antibody to centrosome?
Definition
scleroderma
Term
What is true of the skin in scleroderma?
Definition
tight and atrophic
Term
Where are the most likely locations (2) that scleroderma will present in skin?
Definition

fingers

face

Term
What is sclerodactyly?
Definition
claw fingers
Term
What disease presents with stone facies or mask like face?
Definition
scleroderma
Term
What is Reynauds Phenomenon?
Definition

vasoconstriction leading to ishemia and thus causing triple color change

white to blue to red

Term
What are the two most common GI manifestations of Scleroderma?
Definition

dysphagia

large mouth diverticula

Term
What is the most likely cause of death in scleroderma?
Definition
renal failure
Term
What is sclerodermal renal crisis?
Definition
ischemia in kidney leads to renal hypertension and eventually renal failure
Term
What connective tissue diseases have risks of malignancy?
Definition

Sjogrens

Dermatomyositis

Term
What disease is associated with B-cell lymphoma risk?
Definition
sjogren's
Term
What is keratoconjunctivitis sicca?
Definition
dry eyes
Term
What is xerostomia?
Definition
dry mouth
Term
What occurs to lacrimal and salivary glands in Sjogren's Syndrome?
Definition
they atrophy, fibrosis, and eventually destruct
Term
What two antibodies are seen in Sjogren's?
Definition
anti Ro and anti La
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