Term
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Definition
| Factor I (fibrinogen) - Forms clot (fibrin) |
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Term
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Definition
| Factor II (prothrombin) - Its active form (IIa) activates I, V, VII, VIII, XI, XIII, protein C, platelets |
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Term
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Definition
| Co-factor of VIIa (formerly known as factor III) |
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Term
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Definition
| Required for coagulation factors to bind to phospholipid (formerly known as factor IV) |
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Term
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Definition
| Factor V (proaccelerin, labile factor) - Co-factor of X with which it forms the prothrombinase complex |
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Term
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Definition
| Unassigned – old name of Factor Va |
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Term
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Definition
| Factor VII (stable factor) - Pro Convertin - Activates IX, X |
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Term
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Definition
| Factor VIII (Anti Hemophilic factor A) - Co-factor of IX with which it forms the tenase complex |
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Term
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Definition
| Factor IX (Anti Hemophilic Factor B or Christmas factor) - Activates X: forms tenase complex with factor VIII |
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Term
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Definition
| Factor X (Stuart-Prower factor) - Activates II: forms prothrombinase complex with factor V |
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Term
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Definition
| Factor XI (plasma thromboplastin antecedent) - Activates IX |
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Term
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Definition
| Factor XII (Hageman factor) - Activates factor XI and prekallikrein |
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Term
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Definition
| Factor XIII (fibrin-stabilizing factor) - Crosslinks fibrin |
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Term
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Definition
| Binds to VIII, mediates platelet adhesion |
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Term
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Definition
| Activates XII and prekallikrein; cleaves HMWK |
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Term
| high-molecular-weight kininogen (HMWK) |
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Definition
| Supports reciprocal activation of XII, XI, and prekallikrein |
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Term
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Definition
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Term
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Definition
| Inhibits IIa, Xa, and other proteases; |
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Term
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Definition
| Inhibits IIa, cofactor for heparin and dermatan sulfate ("minor antithrombin") |
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Term
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Definition
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Term
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Definition
| Cofactor for activated protein C (APC, inactive when bound to C4b-binding protein) |
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Term
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Definition
| Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI |
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Term
| Protein Z-related protease inhibitor (ZPI) |
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Definition
| Degrades factors X (in presence of protein Z) and XI (independently) |
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Term
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Definition
| Converts to plasmin, lyses fibrin and other proteins |
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Term
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Definition
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Term
| tissue plasminogen activator (tPA) |
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Definition
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Term
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Definition
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Term
| plasminogen activator inhibitor-1 (PAI1) |
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Definition
| Inactivates tPA & urokinase (endothelial PAI) |
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Term
| plasminogen activator inhibitor-2 (PAI2) |
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Definition
| Inactivates tPA & urokinase (placental PAI) |
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Term
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Definition
| Pathological factor X activator linked to thrombosis in cancer |
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