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CLPH Exam I
Rosacea
22
Pharmacology
Professional
09/29/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Rosacea - General Info
Definition
A common, chronic progressive inflammatory dermatosis based on vascular
instability

Primarily affects the central part of the face

Characterized by facial flushing/blushing, facial erythema, papules, pustules, and telangiactasia
Term
Rosacea - General Info (cont.)
Definition
ages of 25 to 70 years

people with fair complexions

more common in women than men

it is chronic, lasting for years with periods of exacerbation and remission
Term
Telangiactatic Rosacea
Definition
visibly dilated blood vessels
Term
Papulopustular Rosacea
Definition
resembles acne
Term
Phymatous Rosacea
Definition
enlarged sebaceous glands

more common in men
Term
Ocular Rosacea
Definition
watery, bloodshot eyes
Term
Triggers of Rosacea
Definition
foods

temperature

weather

beverages

medical conditions

emotional influences

physical exertion

skin products
Term
Drugs that can trigger rosacea
Definition
VASODILATORS

Topical corticosteroids

nicotinic acid

ACE inhibitors

Calcium channel blockers

Statins
Term
Treatment with lifestyle modifications
Definition
avoid triggers known to exacerbate

avoid excessive exposure to the sun (use sunscreen with SPF 30 or higher)

use mild soaps and cleansers

any topical medication should be allowed to penetrate the skin for 5 - 10 minutes before applying make-up
Term
Treatment of Mild Rosacea
Definition
avoidance of triggers

topical antibiotics

topical retinoids
Term
Treatment of Moderate Rosacea
Definition
oral antibiotics

topical retinoids
Term
Treatment of Severe Rosacea
Definition
Accutane

Laser
Term
Treatment with Topical Antibiotics
Definition
treats the inflammatory stage

topical agents are effective for most patients with rosacea
Term
Metronidazole
Definition
topical antibiotic for rosacea

MetroGel 0.75%
MetroCream 0.75%
MetroLotion 0.75%

treatment of choice

apply twice daily

some burning/stinging
Term
Clindamycin
Definition
topical antibiotic for rosacea

Cleocin T 1% - solution, lotion, gel
Term
Sulfacetamide and Sulfur
Definition
topical antibiotic for rosacea

Sulfacet-R
Rosula Gel
Clenia Cream

apply once or twice daily
Term
Oral antibiotics for rosacea
Definition
for patients with moderate to severe cases

dose varies depending on severity

may be used alone or in combination with topical agents
Term
Examples of Oral Antibiotics for Rosacea
Definition
Tetracycline 250 - 500 mg two to four times daily

Doxycycline 50 - 100 mg once or twice daily

Minocycline 50 - 100 mg twice daily

Patient is tapered off once response is observed
Term
Azelaic acid (Finacea Gel 15%)
Definition
antibacterial, comedolytic, and anti-inflammatory effects

less acidic and better absorbed than the acne formulation
Term
Tretinoin
Definition
Retin-A Micro Gel or Cream

used for more severe cases

may worsen erythema and telangiactasia
Term
Accutane (isotretinoin)
Definition
capsules

only for the most severe cases

risk of serious side effects and teratogenicity
Term
laser therapy
Definition
used to remove blood vessels and reduce excessive redness

a minimum of three treatments is required

may also be used in more severe cases to retard build-up or remove unwanted tissue of the nose
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