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Clinical Nutrition Test 2
Stachenotes PCC Nightengale Nutrition, Upper GI, Lower GI, liver, gal bladder, blood, neuro etc.
114
Biochemistry
Graduate
05/08/2012

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Cards

Term
What is the pathophysiology of GERD?
Definition
Relaxation of gastroesophageal sphincter allowing reflux of gastric acid and pepsin into the esophagus
Term
What are the signs/symptoms of GERD?
Definition
Dysphagia
Heart Burn
Increased Salivation
Belching
Pain radiating to jaw, neck, or back
Term
How can sphincter tone be improved (in GERD)?
Definition
•Lose weight if necessary
•Stop smoking
•Determine if medicine may be the cause
•Remain upright after eating
•Wear loose-fitting clothes
•Sleep with head slightly elevated
Term
Why is it important to control GERD?
Definition
It can lead to Barret's Esophagus (Normal squamous cell epithelium of lower esophagus are changed to metaplastic columnar cell epithelium)
and Esophageal adenocarcinoma
Term
What foods should be avoided to control GERD?
Definition
Foods that impare sphincter pressure:Foods high in fat, chocolate, spearmint, peppermint, alcohol & caffeine
Food that increase stomach acidity: Red & black pepper, coffee (caf. & decaf.), alcohol
•Avoid large meals – consume smaller, more frequent meals instead
Term
Which supplements may be necessary in patients with GERD?
Definition
•Long-term use of GERD meds can lead to calcium, iron & B12 deficiencies; so supplement these.
Term
How is GERD treated in infants?
Definition
Usually resolves within a year
If due to allergy, remove allergen (may be in milk)
Feed elevated and keep elevated 30 min. after feeding.
Term
What do you do if a patient presents with dysphagia?
Definition
Refer to apporopriate provider accourding to clinical presentation
Term
What are some clear liquids & bland foods?
Definition
Clear liquids
•Water
•Apple juice
•Sports drink
•Tea
•Lemonade
•Chicken broth
Bland foods
•Dry toast
•Crackers
•Pretzels
•Potato
•Yogurt
•Sherbet
•Baked chicken
Term
What are the signs/symptoms of gastritis?
Definition
Belching, weight loss, abdominal pain, vomiting & bleeding if severe
Term
What causes most peptic ulcers?
Definition
H. pylori infection causes 70% of all gastric & 92% of all duodenal ulcers
Term
How are peptic ulcers treated?
Definition

Peptic ulcer + H. pylori infection

7-14 days of 2 antibiotics

Proton pump inhibitor (PPI)

Peptic ulcer - H. pylori infection

Antacids

PPI

Histamine blockers

Mucosal protectors

Term
What is the nutrition therapy for peptic ulcers?
Definition

Avoid foods that increase stomach acidity (pepper, coffee, alcohol, caffeine)

Avoid large meals (smaller, more frequent)Supplement Ca, Fe, B12

Term
What is dumping syndrome?
Definition
•Food enters SI too fast, forcing fluid to be drawn into SI to dilute it
•Causes nausea, vomiting, bloating, diarrhea
•Early dumping = 10-20 min after eating
•Intermediate dumping = 20-30 min after eating
•Late dumping = 1-3 hr after eating
Term
Which supplements are indicated in bariatric surgery?
Definition
Most common deficiencies:
•vitamins B12, A, C, D, K, thiamin, folate, iron, selenium, copper, zinc & calcium
Take multivitamin/multimineral & supplements of:
•Vitamin B12, iron, calcium, fat-soluble vitamins
Term
How often should nutrition levels be monitored in patients with geriatric surgery?
Definition
Nutrient levels should be monitored every 3 months
Term
What are the clinical manifestations of diarhea?
Definition

Increased number of BM & decreased consistency of stools

Abdominal discomfort, dehydration, electrolyte imbalance, weight loss

Blood may be present

Term
What are the treatment protocols for acute, osmotic & secretory diarrhea?
Definition

Acute

Rest

Fluids

Osmotic

 Avoid foods that cause (fatty foods, sorbitol)

 Supplemental enzymes may be necessary Secretory

Treat underlying cause

Antibiotics

Remove & treat tumor

Term
What are some nutrition interventions for diarhea?
Definition

Restore fluid/electrolyte balance

Try Pedialyte or Gatorade

Decrease GI motility

Avoid foods/beverages high in simple sugars, sugar alcohols, caffeine & alcohol

Thicken stools

Add soluble fiber

BRAT – bananas, rice, applesauce, toast Repopulate flora of LI

Probiotics & prebiotics

Term
What does BRAT stand for?
Definition
BRAT – bananas, rice, applesauce, toast
diet for thickening stools when someone has diarhea
Term
How is constipation defined?
Definition
1. Average 1 or less bowel movements (BM)/week for at least 12 months.
OR
2. Have at least 2 of the following for 12 weeks in the last year:
2 or less BM/week
Straining during at least 25% of BM
Hard stools during at least 25% of BM
Sensation that not all fecal material is eliminated during at least 25% of BM
Term
What are the most common nutritional diagnoses that accompany constipation?
Definition
Nutrition Diagnosis
•Inadequate fiber intake
•Inadequate food/beverage intake
•Altered GI function
•Undesirable food choices
Term
What nutrition interventions would you recommend for constipation?
Definition

Recommended fiber intake = 10-13g/1000 Cal

Adult RDA = 25-35 g/d

Children RDA = age + 5g fiber/d

Slowly add 1-2 high-fiber foods/d

Increase fluid intake to 8-10 cups/d

Probiotics & prebiotics may also be beneficial

Term
What are the clinical manifestations of fat malabsorption?
Definition
•Malnutrition •Altered GI function •Impaired nutrient utilization •Involuntary weight loss Symptoms •Abdominal pain •Cramping •Diarrhea •Stools are frothy, foul-smelling & greasy in appearance
Term
What are some causes of fat malabsorption?
Definition

Steatorrhea

Inadequate pancreatic enzymes

Impaired bile release

Abnormal motility

Term
What nutritional intervention would be recommended for fat malabsorption?
Definition

Restrict fat to 25-50g/d

Medium chain triglyceride supplements may be used to increase energy (C8 and C10 FA)

Supplement with pancreatic enzymes if necessary

Term
What is not digested/absorbed in carb malabsorption?
Definition
Lactose intolerance
•Inadequate lactase
•Lactose is fermented in LI to SCFA & GAS
Term
How is it carb malabsorption treated?
Definition
Lactose-free diet or supplement with lactase enzymes
Term
What compound causes an inflammatory response in Celiac disease?
Definition
prolamins (alcohol-soluble part of protein found in wheat, rye, malt, barley & oats) damaging SI
Term
What is the etiology of celiac disease?
Definition
•Genetic
•HLA-DQ2 & HLA-DQ8 present in 95% of CD patients
•Autoimmune
•Intestinal damage causes antibody production
•Environmental
•Introduction of gluten too early
•Less time breastfed
•Viral infection in infancy
Term
When should gluten-containing foods be introduced to infants?
Definition
After 3 months, before 7 months
Term
What are the clinical manifestations of CD?
Definition
Diarrhea
•Abdominal cramping
•Bloating & gas
•Bone & joint pain
•Muscle cramps
•Fatigue
•Peripheral neuropathy
•Seizures
•Dermatitis herpetiformis
•Mouth ulcerations
Term
How is CD diagnosed?
Definition
•GOLD STANDARD = SI biopsy
•More common
•Anti-tissue translutaminase (anti-tTG) antibody
•Sensitivity = 90-96%
•Specificity = 95-97%
•Endomysial IgA (EmA) antibody
•Sensitivity = <90%
•Specifity = 100%
Term
What nutrition intervention is performed following diagnosis of CD?
Definition
Initially
•Gluten-free, lactose-free diet
Term
What dietary measures are changed after 1-2 months following a CD diagnosis?
Definition

Can reintroduce lactose!

Remain gluten-free for life

Term
What are some gluten-free options?
Definition
•Amaranth
•Arrowroot
•Bean flours
•Buckwheat
•Corn
•Fava
•Flax
•Nut flour
•Oats (uncontaminated)
•Pea flour
•Potato
•Quinoa
•Rice
•Sorghum
•Soy
•Tapioca
<20 ppm of gluten can be labeled gluten-free!
Term
What is gluten sensitivity? How does it differ from Celiac’s?
Definition
GI symptoms triggered by gluten
Alleviated with gluten withdrawal
Ruled out: CD, wheat allergy, Type 1 diabetes, inflammatory bowel disease & Helicobactor pylori infection
No anti-gluten antibodies or genetic markers
GI lesions may still be present, just not an autoimmune reaction
Mechanism has not been elucidated
Term
What is the pathology of ulcerative colitis & Crohn’s?
Definition
Ulcerative Colitis
•Inflammation of the mucosa & submucosa
•Involves rectum only in 50% of patients
•Limited to colon only
•Peak onset 20-30 years
Crohn's
•Inflammation of the mucosa
•Mostly in ileum & colon
•Peak onset teens to 20’s
Term
What differs between the symptoms & complications in Ulcerative Colitis and Crohn's?
Definition

Ulcerative Colitis

Bloody, mucusy diarrhea

Abdominal/rectal pain

Fever

Weight loss

Possible constipation

Arthritis

Dermatitis

Ocular manifestations

Crohn's

Chronic diarrhea

Severe abdominal pain

Anorexia

Weight loss

Malnutrition

Fever

Growth retardation

Term
What diet & supplements should be recommended during an IBD (UC and Crohn's) flare?
Definition
•MVM
•B12 (Crohn’s; nasal gel or injection)
•Zinc (12-15 mg/L stool output)
•Calcium
•Magnesium
•Copper (0.5-1.5 mg/day)
•Probiotics/Prebiotics
Term
What should be limited in the diet for IBD patients, even during remission?
Definition
Limit foods high in oxalate (cocoa, tea, peanut butter, spinach, nuts, strawberries, tofu, backed beans, high dose vitamin C)
Term
What is the difference between IBS-D, IBS-C & IBS-M?
Definition
IBS-D = diarrhea predominant
IBS-C = constipation predominant
IBS-M = mixed diarrhea & constipation
Term
What is the pathophysiology associated with IBS-D, IBS-C & IBS-M?
Definition
Altered serotonin production
•Serotonin causes release of:
Acetylcholine = smooth muscle contraction
Nitric oxide = smooth muscle relaxation
•Serotonin reduced in IBS-C; increased in IBS-D
Term
What is the FODMAP restriction?
Definition

Don't eat foods with Fermentable Oligo-, Di- and Mono-saccharides, and Polyols.

Helps with IBS

Term
Should insoluble fiber be recommended to IBS patients?
Definition
It may exacerbate IBS!
Term
How is diverticulosis treated?
Definition
High fiber diet (25-35 g/day + 6-10 g extra)
Fluids
Term
How is diverticulitis treated?
Definition
Antibiotics
Bed rest
Liquid diet
Term
How much protein is required for alchoholic liver diseased patients?
Definition
1.5-2.0 g/kg bw
Term
What supplements are recommended for patients with alchoholic liver disease?
Definition
Thiamin 50-100 mg for 7-14 days
Folic acid 1000 mcg/day
Riboflavin Amount in a multivitamin (MVM)
B6 1-3 mg as part of a MVM
B12 6-12 mg as part of a MVM
C 175-500 mg/day
A Amount in a MVM
D 200-500 IU/day
E 10-50 IU as part of a MVM
Fe Standard amount in MVM for premenopausal women; Find a MVM without for men &
postmenopausal women
Mg 100-400 mg/d if deficiency suspected
Se 5-50 mcg/day
Zn Amount in MVM
Supplements in Alcoholism
Nelms
Term
What are the clinical manifestations of gall stones?
Definition
may be asymptomatic
Right quadrant pain
Term
What nutritional intervention would be recommended for gallstones?
Definition
• Low fat diet (<30% Cal)
•Moderate protein
• Smaller, more frequent meals
• Rest bowel with attacks
•Water-soluble supplementation of ADEK may be
necessary
• After surgery, more fiber may be necessary
Term
What are some causes of kidney stones?
Definition
Hypercalciuria, gout, excess vitamin D intake, UTI
Term
What nutritional intervention would be recommended for kidney stones?
Definition

• Increase fluid intake by 3 L/d (at least 50%    from water)

• Not necessary to limit dietary calcium (dairy can actually prevent kidney stones)

• Limit oxalate intake to 50-60 mg/d

• Avoid: beets, chocolate, cola, coffee/tea, nuts/nut butters, berries, wheat bran, spinach, rhubarb & high dose vitamin C

• For stones high in uric acid, avoid high purine foods

Term
What are some high oxalate foods?
Definition
cocoa, tea, peanut butter, spinach, nuts, strawberries, tofu, backed beans, high dose vitamin C
Term
How is it type 1 diabetes diagnosed?
Definition
Diagnosis (1 of the following)
• Symptoms + blood glucose >200 mg/dL
• Fasting plasma glucose >125 mg/dL
• Plasma glucose >200 mg/dL after oral glucose tolerance test
(OGTT)
Term
What % of energy should be coming from carbs, proteins & lipids?
Definition
• Protein = 15-20% Cal
• Lipids = 30% Cal
• Carbs = 45-65% Cal
Term
What is the basis of carb counting?
Definition
Best method of maintaining blood glu
• Total intake of CHO intake, not source
• Count starches, fruits, dairy, sweets
• Nonstarchy veggies don’t need to be
counted as long as <15 g CHO are not eaten
Term
Is exercise recommended for T1DM?
Definition
Absolutely
Term
What are some short-term & long-term complications for T1DM?
Definition
Short Term:
hyperglycemia
Ketoacidosis
hypoglycemia
Long Term
CVD
Nephropathy
Retinopathy
Peripheral neuropathy
Autonomic neuropathy
Term
How is the pathology of T2DM different from T1DM?
Definition
T2DM is insulin-independent
Term
What compound phosphorylates IRS-1?
Definition
C-reactive protein
Term
What are some risk factors for type 2 diabetes?
Definition
Genetics (<25 years)
Obesity
Physical inactivity
High birth weight babies
Low birth weight babies
Term
How much exercise is recommended for T2DM patients?
Definition
30-45 min of mod. intensity exercise 3-
5 days/week
Resistance exercise
3 days/week
Term
What nutrition therapy would be recommended for T2DM?
Definition

Weight loss

Decrease caloric intake (1200-1600 Cal) Increase physical activity

Carbs 

 Get at least 130 g carbs per day 

 Carb counting is recommended

Protein 

 No more than 20% Cal/day 

 With nephritis, limit to 10% Cal/day

Fat 

 25-35% Cal 

 Limit saturated fat to ~7%, trans fat 0%

Fiber 

 Get 25-38 g/day from fruits, veggies, whole Fiber grains & legumes

Term
What supplements may be beneficial for T2DM?
Definition
A
• Alpha-lipoic acid
• Konjac glucomannan
B
• Beta-glucan
• Fenugreek
• Ginseng
• Gymnema
•Magnesium
• Vanadium
• Whey protein
Term
What are some complications to gestational diabetes for the mother?
Definition
• Hypertension
(preeclampsia),
excessive amniotic
fluid, premature
delivery, difficult birth,
higher C-section rate
Term
What are some complications to gestational diabetes for the infant?
Definition
Large for gestational
age, hypoglycemia,
respiratory distress,
hypocalcemia,
jaundice &
polycythemia
Term
What are the recommendations for protein, fat, carbs & sodium in those with T3DM?
Definition
Protein RDA = 1.1 g/kg of desirable BW
Fat Limit saturated & trans fat
Carbs Space throughout the day to avoid ketonuria
Sodium Not restricted during pregnancy
Term
What is the difference between reactive & fasting hypoglycemia?
Definition

Reactive hypoglycemia: diabetics that administer too much insulin 

 Fasting hypoglycemia: excess insulin or insulin-like substances (drugs, alcohol, etc.)

Term
How is hypoglycemia diagnosed?
Definition
All three of the following must be present:
1. Low blood glucose (<70mg/dL)
2. Weakness, fatigue, sweating, palpitations
3.Symptoms disappear with carb ingestion & blood glucose returns to normal
Term
What nutrition therapy would be recommended for hypoglycemia?
Definition
1. Small, frequent meals with complex carbs, fiber & protein
2. Avoid simple carbs & alcohol
3. Limit caffeine (reduces cerebral blood flow)
Term
Can goitrogens be consumed by hyper or hypothyroid patients?
Definition
Term
What nutrition therapy is recommended for hyper and hypothyroid patients?
Definition
The only nutrition therapy
for disorders of the
thyroid & pituitary gland
are to minimize food-drug
interactions.
Term
Is adrenal insufficiency reversible?
Definition
depends on the cause
Term
How is adrenal insuficiency diagnosed?
Definition
give a dose of ACTH & measure blood concentrations of cortisol
Term
How is adrenal insuficiency treated?
Definition
Term
Is chronic fatigue reversible?
Definition
Yes
Term
How is chronic fatigue diagnosed?
Definition
Low (unstimulated) saliva cortisol levels CAN be used to
diagnose chronic fatigue syndrome
Term
How is Chronic Fatigue treated?
Definition
Exercise, cognitive behavioral therapy
Term
What is the etiology of microcytic anemia
Definition
Blood loss (menstruation, gastric ulcer)
Inadequate Iron (intake or absorption)
Infancy/Childhood (cows milk interferes with absorption, soy formula Must be iron fortified)
Pregnancy
Excess minerals (divalent)
Term
What are some health conditions associated with microcytic anemia?
Definition
Pica
Childhood obesity
Term
What are the clinical manifestations of microcytic anemia?
Definition
pallor, fatigue, cold extremities, malaise, tachycardia (HR >100 beats/min)
Term
What are some biomarkers for microcytic anemia?
Definition
Term
What are some strategies for increasing dietary & supplemental iron?
Definition
Increase vitamin C
Molasses
Cast iron pans
Term
What else needs to be taken if iron supplements are indicated?
Definition
Zn (Fe inhibits Zn absorption)
Term
What is the cause of regular megaloblastic vs. pernicious anemia?
Definition
Megaloblastic caused by folate & B12 deficiencies
pernicious a type of megaloblastic caused by atrophic gastritis or Autoimmune issue
Term
How is B12 absorbed?
Definition
Term
What are folate & B12 required for in the body?
Definition
Required for 1C metabolism (methylation) in rapidly dividing cells.
Term
What are the clinical manifestations of megaloblastic anemia?
Definition
pallor, fatigue, irritability, neuropathy if prolonged
Term
What are some biomarkers for megaloblastic anemia?
Definition
holotranscobalamin II or methymalonic acid (MMA)
Term
How is megaloblastic anemia treated?
Definition
•Limit carbonated soft drinks (associated with folate def.)
•Increase folic acd & B12 fortified cereals
•Be careful, folate repletion can mask a B12 deficiency!
•Dietary interventions should be tried prior to supplementation
•B12 supplements are made from cyanocobalimin – a weakly active B12
Term
What nutrition education would be important for Hemochromatosis?
Definition
EDUCATION: heme vs. non-heme iron, vitamin C
avoidance of cast-iron, MVM with iron & alcohol
increase fiber, phytates & tannin consumption, limit meat
Term
What deficiency is related to restless leg syndrome?
Definition
iron deficiency or altered iron metabolism
Term
How is restless leg syndrome treated?
Definition
High dose supplementation is required
Fe supplements >250 mg/dose, 2-3 times/day
Take with vitamin C, separately from other mineral supplements
Term
What diet is often prescribed for epilepsy?
Definition
Ketogenic diets = high fat, low carb
Classic
Medium-chain triglyceride
Low-glycemic index
Modified Atkins diet
Term
Is the ketogenic diet indicated for patients taking Topamax?
Definition
will cause weight loss and kidney stones if combined
Term
What macronutrient ratio is used in the classic version of the ketogenic diet?
Definition
4:1
Term
What supplements are necessary for the ketogenic diet?
Definition
Patients need to take a sugar-free multivitamin, calcium & vitamin D supplements
Term
What are some risk factors of stroke that may be influenced by diet?
Definition
HTN
CCD
Diabetes
Dyslipidemia
Obesity
Term
What are some dietary measures that may reduce the risk of stroke?
Definition
•Rich in fruits, veggies, nuts, soy & cereal fiber
•More fish & poultry than red meat
•More PUFA than SFA
•Low in trans fat
•Multivitamin use for >5 years
Term
What causes an aneurysm?
Definition
smoking
alchohol
Term
Should vitamin B6 supplements be given to a patient with Parkinson’s disease taking L-dopa?
Definition
no, it speeds up the process of converting L-dopa to dopamine.
Term
What are some dietary strategies to control GERD & constipation commonly seen in Parkinson’s?
Definition
Encourage smaller, more frequent meals
Low in fat & fiber
Term
What is the etiology involved in MS?
Definition
Genetics
•Region on chromosome 6 encoding mutated interleukin receptors (IL7R & IL2RA)
Environmental factors
•Latitude – decreased vitamin D associated with MS
•Smokers are 70% more likely to develop MS
•Hygiene hypothesis – delayed exposure to certain viruses (Epstein-Barr virus) increases risk of MS
Term
What dietary restrictions & supplements are recommended in MS?
Definition

Restriction of SFA

Omega-3 supplements

Supplementation of Ca & vitamin D (required with long-term corticosteroid use) 

Term
What is the etiology involved in Alzheimer’s disease?
Definition
age
genetics (mutation in apolipoprotein Ee4)
Obesity, CVD, diabetes, free-radical catalyzed oxidation, Down syndrome, previous brain trauma
Term
What dietary strategies can be employed to prevent Alzheimer’s?
Definition
Caloric restriction (as 30% less E from carbs only) has been successful in preventing AD in animal models
Decreased beta-amyloid plaque production
Control blood glucose
Normal blood pressure
Term
Can the Mediterranean diet decrease the risk of Alzhemier’s?
Definition
Heck yes
Term
What supplements may be beneficial in Alzheimer’s?
Definition
•Liquid supplements are best
•Under investigation in early stage AD:
•omega-3 FA
•B vitamins
•vitamin C
•vitamin E
Term
What supplements may increase the risk of Alzheimer’s?
Definition
Cu in older patients
MVM condtaining Fe in older patients
Term
What dietary strategies may be recommended to enhance food consumption by decreasing mealtime confusion in your Alzheimer’s patient?
Definition
•offer 1 food at a time •use simple place setting •plate should be a different color than table •add condiments prior to serving •focus on finger foods •allow adequate eating time (30-45 min) •maximize food intake during lunch (cognition is usually best at this time)
Term
What is the major cause of traumatic brain injuries? Spinal cord injuries?
Definition
Falls (28%), motor vehicle accidents (20%), ‘struck by/against’ (19%), firearms (11%), bike accidents (3%)
Term
What caloric & protein recommendations are given for patients with brain or spinal cord
injuries?
Definition
Acute
Energy intake should be 10% below predicted REE
•Protein = 2.0 g/kg bw/day
Rehab
•paraplegic = 27.9 kcal/kg bw
•quadraplegic = 22.7 kcal/kg bw
•Protein = 0.8-1.0 g/kg bw/day
Term
What supplements may be utilized for your patients with spinal cord injuries?
Definition
Omega-3s may be beneficial for improved performance
Vitamin D deficiency is very common in SCI patients
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