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Clinical Chemistry Exam 1 Lecture 8
Cardiac Markers
39
Chemistry
Undergraduate 3
01/31/2015

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Term
Dyspnea
Definition
Difficulty Breathing
Term
Cyanosis
Definition
Bluish coloration to skin as a result of dyspnea
Term
Ischemia
Definition
Decreased blood flow to the heart, leads to myocardial infarction
Term
Angina
Definition
Chest pain usually due to ischemia
Term
Atherosclerosis
Definition
Hardening of artery caused by cholesterol plaques
Term
5 General Classifications of Cardiac Disease
Definition
Congenital Heart Disease
Congestive Heart Failure
Acute Coronary Syndrome
Hypertensive Heart Disease
Infective Heart Disease
Term
Diagnosing AMI
Definition
Symptoms
ECG
Cardiac Markers
Term
What % is ECG diagnostic?
Definition
50
Term
For proper diagnosing and monitoring, you should run at least how many markers as well as look for serial changes?
Definition
2
Term
Myoglobin
Definition
Muscle protein that facilitates the entry of oxygen into muscle cells
Rapidly released from damaged muscles
Term
Myoglobin begins to rise _____ hours post AMI
Definition
1-4
Term
Myoglobin clears the glomerulus post AMI and returns to normal by _____ hours
Definition
24
Term
Is Myoglobin a reliable indicator of AMI in patients with renal disease or skeletal muscle trauma?
Definition
No
Term
What is Myoglobin a good indicator of?
Definition
Re-infarction
Term
Troponin I
Definition
Muscle protein that regulates contractions
Term
What Cardiac Marker is the Most specific and Sensitive for Myocradial injury?
Definition
Troponin I
Term
Troponin I peaks at ___ hours; persists for ___ ____ post AMI
Definition
24
several days
Term
Is Troponin I found in normal healthy serum?
Definition
No
Term
Troponin T peaks at ____ hours and remains elevated for _____ _____
Definition
48
7+ days
Term
What Cardiac Marker is useful for diagnosing patients who delayed seeking medical attention?
Definition
Troponin T
Term
CKMB peaks at ___ hours and returns to normal within ___ hours
Definition
24
48
Term
NR of CKMB is equal to
Definition
0-5 ng/mL
Term
True or False:
Increased levels of CKMB are also seen in some muscle diseases
Definition
True
Term
CKMB Relative Index
Definition
To differentiate cardiac vs non-cardiac CKMB
Term
CKMB RI =
Definition
(CKMB Total / Total CK) x 100
Term
CKMB Relative Index >3 is indicative or what?
Definition
AMI
Term
True or False:
CKMB Relative Index is useful only when Both Total CK and CKMB are Elevated
Definition
True
Term
hs-CRP
Definition
Sensitive marker for Chronic Inflammation
Term
Mild baseline elevations of hs-CRP in "healthy" people is associated with high risk for what?
Definition
future cardiac events
Term
Interleukin-6 (IL6)
Definition
Cytokine secreted by T cells and macrophages
Term
Is Interleukin-6 a sign of inflammation?
Definition
Yes
Term
What substances are needed to eliminate homocysteine?
Definition
B vitamins and folic acid
Term
Deficiencies in Vitamins B and folic acid contribute to what?
Definition
Accumulation of homoecyteine
Term
There is a link between high homocysteine levels and ____ __ __ ___, causing ____ and the formation of blood clots
Definition
damage to the arteries
atherosclerosis
Term
List 2 new markers that are under development
Definition
Fibrinogen
D-dimer
Other new markers
Term
B natriuretic peptide (BNP) & N-terminal pro b-type natriuretic peptide (NT-ProBNP)
Definition
Hormone secreted by cardiac ventricles to stimulate urinary excretion of sodium
Term
BNP and NT-ProBNP are increased in diseases characterized by what?
Definition
Expanded fluid volume not associated with necrosis
Term
What illness is an example of when BNP and NT-ProBNP are elevated?
Definition
Congestive Heart Failure
Term
The higher the level of BNP and NT-ProBNP, the _____ the prognosis
Definition
Poorer
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