Term
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Definition
Formation of Platelet Plug
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Term
| Primary Hemostasis Players |
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Definition
Platelets
Collagen (endothelium)
vWF
Fibinogen |
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Term
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Definition
Concentration tests:
CBC to look at Platelet #
Species-specific Immunoassy to look at vWF#
Functional Tests:
Buccal Mucosal Bleeding Time
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Term
| Buccal Mucosal Bleeding Time |
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Definition
Used to assess the function of 1˚ hemostasis
INDEPENDENT of coagulation cascade
will have a prolonged time with:
Thrombocytopenia (dec. Platelets)
Platelet dysfunction
von Willebrand dz |
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Term
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Definition
If a shop keeper wants to sell something for $12... he will sell it for $11.98.
9&8 are a complex
the middle #'s (11&9) use calcium |
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Term
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Definition
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Term
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Definition
| Activated by Tissue Factor |
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Term
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Definition
Tissue Factor + Factor 7 + Ca+ + Phospholipid (platelets)
This complex activates 10 --> 10a
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Term
| Platelet Phospholipid from activated platelets is needed in which complexes? |
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Definition
1. In Extrinsic Pathway (TF,7, Ca+, PL) converts 9 and 10 --> 9a and 10a
2. Intrinsic Pathway (9+8 +Ca+ +PL ) converts 10 -->10a
3. Common Pathway (10a +5a+PL + Ca+) converts 2-->2a (thrombin) |
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Term
| Thrombin (2a) activates 3 factors that act as AMPLIFICATION LOOPS |
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Definition
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Term
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Definition
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Term
Activated Clotting Time (ACT)
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Definition
INTRINSIC/COMMON PTWY TEST
o Less sensitive than PTT and requires platelets for PL
§ Have to have a SEVERE coag problem to pick up
o Don’t need special Equipment – put in tube and see how long it takes to clot.
o Contact w/Collection tube activates 12
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Term
· Partial Thromboplastin Time (PTT)
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Definition
Intrinsic Ptwy Test
Add PL and Ca+ to assay
o Add activator of factor 12
o Run more routinely à use plasma
§ More sensitive
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Term
| Intrinsic and Common Pathway tests |
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Definition
Activated Clotting Time (ACT)
Partial Thromboplastin Time (PTT) |
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Term
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Definition
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Term
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Definition
Extrinsic Ptwy Test
Use Plasma
o Add PL and Ca+
o Add source of TF
§ Detects time it takes for Fibrin Formation
o Tests from 7 down
§ 7, 10, 5, 2, 1,
o Wont tell you which exact one is loss
§ Need to lose 70 – 80% to see delay
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Term
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Definition
| Used to measure Fibriongen |
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Term
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Definition
From Endothelial Cells
ONLY functional in the presence of FIBRIN
wont get plasminogen --> Plasmin w/o Fibrin present |
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Term
| MPV - Mean Plalelet Volume |
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Definition
| Only used as support for increases platelet production b/c their larger |
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Term
| Increase in FDP's and D-Dimer |
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Definition
Decreased Removal by liver/Kidney
or Increased production via
Excessive thrombi formation
sepsis
Internal Hemorrhage |
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Term
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Definition
| Only Cross-linked fibrin Breakdown |
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Term
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Definition
| Can be Fibriongen or Fibrin |
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Term
| Vitamin K deficiency causes |
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Definition
Warfarin or Cumarin - Antagonism
Cholestasis --> Dec. Fat Absorption --> Dec. Vitamin K absorption (b/c fat soluble)
Maldigest/Malabsorption --> Dec. Absorption of V. K |
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Term
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Definition
excess clotting (DIC) --> Increased production of FDP
Liver Disease --> decreased removal |
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Term
| Decreased Fibrinogen ruleouts |
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Definition
Liver Disease --> Decrease production of Fibrinogen
Consumption of Fibrinogen
Prob not Vitamin K b/c only 2,7,9 10 and Fibrinogen is factor 1 |
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Term
| DIC - Disseminated Intravascular Coagulation (Comsumptive Coagulopathy) |
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Definition
NEVER a 1˚ disease
Clue for significant underlying dz causing activation of hemostatic pathways
Causes usually
Wide-spread exposure of Tissue Factors
Endothelial damage/Activation
Circulating foreign material and
Procoagulant release (venoms) |
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Term
| How to test for Fibrinolysis (Fibrin breakdow by plasmin |
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Definition
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