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class notes 2 pharmacology
class 3
44
Nursing
Undergraduate 3
09/08/2015

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Term
1 liter of water is ____lbs
Definition
2.2
Term
approximitely ___% of the adult body is water
Definition
60
Term
within cell-fluid is water called
Definition
intracellular fluid
Term
fluid is regulated by: 1.2.3.4.
Definition
1.osmosis 2.filtration 3.diffusion 4.active transport
Term
Movement of fluid from and area of lower solute concentration to an area of higher solute concentration
Definition
osmosis
Term
Movement of molecules and ions from an area of higher concentration to an area of lower concentration
Definition
diffusion
Term
Movement of water and solutes from an area of higher hydrostatic pressure to an area of lower hydrostatic pressure
Definition
filtration
Term
-Physiologic pump that moves fluid from area lower concentration to area higher concentration
-Movement against concentration gradient
Definition
active transport
Term
Sodium-potassium pump maintains higher concentration extracellular ___ and intracellular _____
Definition
sodium, potassium
Term
Hydrostatic pressure can be thought of as “_____ pressure,” and osmotic pressure can be thought of as “_____” pressure.
Definition
pushing, pulling
Term
Proportion of dissolved particles (solute) in volume of fluid
Definition
blood osmolarity
Term
When plasma osmolarity increases 1.___ is released & less 2.___ excreted (more concentrated urine)
Definition
ADH, H2O
Term
Fluid volume deficit (FVD) 1.____
fluid volume excess (FVE) 2.___
Definition
1. hypovolemia 2. hypervolemia
Term
*Produced primarily by heart response to changes ECF volume.
*When B/P increases, this chemical is released
• this chemical acts on kidneys to increase Na+ excretion • Leads to decrease ECF volume.
low blood pressure inhibits the release of this chemical
Definition
atrial naturietic peptide (ANP)
Term
* loss of water alone with increased serum sodium level
• Causes: vomiting, diarrhea, GI suctioning, sweating, decreased intake/ inability gain access fluids
Definition
dehydration
Term
heart failure, renal failure, cirrhosis of liver are risk factors for:
Contributing factors: excessive dietary sodium or sodium-containing IV solutions
Definition
fluid volume excess
Term
*Sodium
• Potassium
• Chloride
• Bicarbonate
Definition
1.135-145 2. 3.5-5.0 3. 98-106 4. 24-31
Term
Regulates extracellular fluid volume and
osmolarity
normal level is ___-___
Definition
sodium--135-145
Term
when sodium levels go below 135, hypertonic, restrict H2O+other fluids
Definition
hyponatremia
Term
when sodium levels are above 145, water deficit
Definition
hypernatremia
Term
Maintains intracellular osmolarity
Controls cell resting potential
Exchanged for H+ to buffer changes in blood pH
Definition
potassium
Term
Normal level is 8.5–10.5 mg/dL
• Extracellular: nerve impulse; blood clotting
• Intracellular: needed for all muscle contraction
Definition
calcium
Term
– Blocks more Na+gates
– Nerves are less able to fire
Definition
hypercalcemia
Term
– Blocks fewer Na+ gates –
Nerves fire more easily
Definition
hypocalcemia
Term
• Trousseau’s Sign • Chvostek’s Sign • Tetany/spasm
• Tap or touch cheek • Elicit twitch/spasm are all signs of
Definition
hypocalcemia
Term
• Cofactor enzymatic reactions (Involving ATP; DNA replication; mRNA production)
• Metabolism of carbohydrates & Proteins
normal level is 1.8-2.7
Definition
magnesium
Term
Key respiratory & metabolic mediators work concurrently keep ______ levels normal and stable and to maintain homeostasis
Definition
hydrogen ion (H+)
Term
pH stands for
Definition
potential hydrogen
Term
measures acidic or basic (alkaline) nature of substances.
Definition
pH (potential hydrogen) scale
Term
Individual acids have different functions:
1. byproducts of energy metabolism
2. digestion
3. "food" for brain
Definition
1. lactic acid, carbonic acid
2. hydrochloric acid
3.ketoacids
Term
C02 spontaneously combines with water in blood to form ____, therefore CO2 is considered _____
Definition
Carbonic acid, acid!
Term
HCO3 Will spontaneously combine with ___ in blood to neutralize.
Therefore HCO3- considered _____
Definition
1. hydrogen (H+)
2. base
Term
When PaCO2 levels become ABNORMALLY high, leads to decrease pH, resulting in:
Definition
respiratory acidosis
Term
When PaCO2 levels become ABNORMALLY low, leads to increase pH, resulting in:
Definition
respiratory alkalosis
Term
When PaCO2 levels become ABNORMALLY low, leads to increase pH, resulting in respiratory alkalosis...this can be caused by
Definition
hyperventilation
Term
– Increased levels of keto acids,lactic acid,etc.
– Decreased bicarbonate levels
Definition
metabolic acidosis
Term
– Decreased H+ levels
– Increased bicarbonate levels
Definition
metabolic alkalosis
Term
When HCO3- levels become ABNORMALLY high, results in:
Definition
metabolic alkalosis
Term
When HCO3- levels become ABNORMALLY low, results in:
Definition
metabolic acidosis
Term
Breathing adjusts ____ levels to bring pH back to normal
Definition
CO2
Term
metabolic alkalosis can be caused by
Definition
hypokalemia
Term
Most commonly due to vomiting or gastric suction; may also be caused by medications, especially long-term diuretic use
Definition
metabolic alkalosis
Term
evaluate ability lungs move oxygen into blood & remove carbon dioxide from blood.
Definition
ABG's----arterial blood gasses
Term
• pH:
• PaCO2:
• HCO3:
• PaO2:
• Oxygen saturation >
Definition
1. 7.35-7.45
2. 35-45
3. 22-26
4. 80-100
5. 93-100%
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