Term
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Definition
Blocks the Choline/Na+ transporter into the cell and stops ACh synthesis
Blocks the ACh/H+ pump into the vessicles and prevents storage
Both only used in lab |
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Term
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Definition
G- Proteins located within all Para-symp, CNS, and some sympath
Since these G proteins need to be activated they take time to respond |
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Term
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Definition
Presynaptic- blocks calcium channels and prevents binding of ACh to the presnatic terminal
Postsynaptic- inhibitory and will inhibit adenylyl cyclase which increases intracellular K+ and hyperpolarizes the cell |
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Term
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Definition
Coupled to G proteins which stimulate Phospholipase C, and are excitatory neurons
1/5-CNS (Arousal attention,EPSP)
3-SM (Contractions) |
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Term
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Definition
Ligand based, need 2 molecules of ACh to bind to ellict a comformational change.
Allows K and Na ion flow. (Mostly Na into cell)
ACh binds onto Alpha subunits to elicit changes |
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Term
| Desensitied Nicotinic Receptors |
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Definition
| When a nicotinic receptor undergoes contiuned and extended exposure to ACh there will be a "locking of the channel" and ACh will remain bound to the receptor |
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Term
| What are the two types of cholinesterases that break down ACh |
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Definition
AChE and butyrylcholinesterase BuChE
BuChE may be seen in Alzhemers pathology |
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Term
| What do presynaptic Nm do to upregulate themselves |
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Definition
| They stimulate ACh mobilization of synaptic vessels from the reserve pool to the depot pool |
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Term
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Definition
When over 50% of the nicotinic recepoters are desenitized
Hexamethonium- can cause this by blocking presynape Nm receptors and not allowing facilitation |
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Term
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Definition
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Term
| The heart is influenced most by which system when at rest |
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Definition
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Term
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Definition
Blockage of vagal slowing of SA node---> increased heart rate
Muscarinic Antagonist |
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Term
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Definition
degrades SNAP-5 and prevents ACh release by stopping vesicle binding
Used to stop muscle contractions (Torticollis, wrinkles, headaches, pain) |
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Term
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Definition
| ACE inhibitor--- fast and rapid reversable block |
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Term
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Definition
| ACE inhibitor--- fast and rapid reversable block |
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Term
Physiotigmine
Ambenonium
Endophonium
Pyridostigmine
Neostigmine |
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Definition
ACE INHIBITORS
Endophonium- used for diagnosis
Neostigmine- used for GI distention
Physostigmine- can cross BBB
Ambenonium/Pyridostigmine/Neostigmine- used for Myasthenia gravis treatment |
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Term
| Tacrine, Doneepezil, Rivastigmine, Galatamine |
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Definition
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Term
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Definition
| Asthma diagnosis- muscarinic receptors |
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Term
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Definition
Glaucoma-- constricts pupils, lowers pressure
M agonist |
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Term
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Definition
GI and Urinary issues
Mus. Agonist |
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Term
| Pilocarpine and Cevimeline |
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Definition
| Treat dry mouth due to Sjorgrens syndrome by increasing salvation |
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Term
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Definition
| Produces neuromuscuar blockade for surgery |
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Term
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Definition
| prevention of motion sickness, mild sedation, and decrease oral secretions |
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Term
| Pirenzepine, Methscopolamine, Glycopyrrolate |
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Definition
Peptic Ulcer disease
Prevent bradycardia during surgery--- Glycopyrrolate |
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Term
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Definition
| COPD treatment, brochiodilator |
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Term
| Oxybutynin, Propantheline, Terodiline, tolterodine, trospium, darifenacin, Solifenacin |
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Definition
Overactive bladder
Oxy, Pro, Tolt, Tros are nonspecific muscarinic
Darifenacin, Solifenacin are Selective M3 antagonists (cause less dry mouth and constipation) |
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Term
| Mecamylamine and Trimethaphan |
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Definition
| Treat aortic dissection to lower BP and blunt sympathetic reflexes that would normall cause a tear |
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