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Cholinergic Antagonists
Neuro 3 Pharm
20
Pharmacology
06/06/2011

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Cards

Term
Atropine
Definition
- competitive inhibitor at all 5 receptors
- Different response based off dose
- Uses: antidote to AChE ihibitors, retinal exam, adjivant in anesthesia
- adverse effects: mydriasis, blurred vision, constipation, urinary retention, dry mouth, hot skin
Term
.5-1 mg atropine
Definition
Slight bradycardia, followed by tachycardia, dry mouth, thirst, inhibition of sweating, slightly dilated pupils
Term
2 mg atropine
Definition
Dilated pupils (mydriasis), blurred near vision (cycloplegia)
Term
5 mg atropine
Definition
Dry and hot skin, urinary retention
Term
10 mg or more of atropine
Definition
Cardiovascular depression, coma, respiratory failure
Term
Physostigmine
Definition
Antidote to atropine
Term
Scopolamine
Definition
- blocks all 5 muscarinic recepotrs
- for treatment of motion sickness
- similar adverse effects to atropine, with more CNS depression
Term
Ipratratropium
Definition
- blocks M3
- treats Asthma, COPD
Term
Dicyclomine
Definition
- blocks M3
- treats IBS, can be used for urinary incontinence
Term
Tolterodine
Definition
- blocks M3
- used for urinary incontinence
- adverse effects- dry mouth
Term
Tropicamide
Definition
- blocks M3
- dilates pupil for exam
- adverse effects- blurred near vision
Term
Mecamylamine
Definition
- competitive nicotinic receptor blocker
- ganglionic blocker
- used in patches for smoking cessation
Term
Effects of nicotine
Definition
- tachycarida, increased BP, broncial, calivary, and sweat secretions
Term
Pancuronium
Definition
- blocks Nm (competitive blocker)
- used for muscle relaxation
Term
Tubocurarine
Definition
- blocks Nm (competitive blocker)
- used for muscle relaxation
- adverse effects: histamine release, allergy
Term
Succinylcholine
Definition
- depolarizing blocker of Nm
- Produces a persistent partial depolarization by not allowing the threshold of AP to be achieved
- 2 phases: I- Produces persistent partial depolarization by not allowing the threshold for AP to be achieved. This is followed by desensitization of nicotinic receptors to action of ACh and closing of Na channels leading to paralysis of muscle.
- closes Na channels
- muscle relaxation
Term
Ganglionic blockers
Definition
trimethaphan, hexamethonium
Term
Uses of Atropine
Definition
excessive salvation, to produces cycloplegia
Term
contraindications of cholinergic antagonists
Definition
glaucoma, GI obstruction or atony
Term
hexamethonium
Definition
ganglionic inhibitor
binds to Na channel to prevent Na influx