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CHF
pharm II 2
27
Pharmacology
Graduate
10/04/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
High output HF
Definition
heart pumps normal volume but metabolic demand is above normal
Term
Low output HF
Definition
heart pumping volume is diminished and can't meet normal metabolic needs
Term
systolic dysfunction
Definition
Decreased contractility caused by reduction in muscle mass (AMI), ventricular hypertrophy (Pressure overload or Volume overload) and cardiomyopathies
Term
Diastolic dysfunction
Definition
Restriction in ventricular filling caused by increase ventricular stiffness (ventricular hypertrophy) and mitral or tricuspid stenosis
Term
Congestive HF
Definition
Left ventricular systolic dysfunction with the classic symptoms of fatigue, shortness of breath, and fluid retention
Term
Inotrope MOA
Definition
Na/K pump inhibitor, increase Na--> increase Ca
Term
Digoxin (Lanoxin)
Definition
systolic failure TX- positive inotrope, Cardiac glycoside. ↑ CF, modulate neurohormone action;- improve symptoms, prevent deterioration
Term
Dobutamine (DA)
Definition
Inotrope- SAS agonist, hosp. IV. ↑cAMP & Ca. improve symptoms
Term
Milrinone
Definition
Inotrope- PDE inhibitor, hosp. IV. ↑cAMP & Ca. improve symptoms
Term
Hydralazine
Definition
Afterload reducer- ↓ TPR, aterial and renal dilator. AE- HA, dizz, hepatic dysfunctiopn, lupus. improve symptoms
Term
Alpha- antagonists in HF
Definition
afterload reducers- bad
Term
calcium channel blockers in HF
Definition
afterload reducers- ↓inotropy. Systolic failure, increased mortality. bad
Term
nitrates in HF
Definition
preload reducers- improve symptoms
Term
diuretics in HF
Definition
preload reducers- improve symptoms
Term
hydralazine + ISDN
Definition
afterload/preload reducer, improve survival. ↓TPR &↓ VR
Term
ACE inhibitors in HF
Definition
afterload/preload reducer, improve survival. ↓ VR & TPR, ↑SV &CO
Term
ARBs in HF
Definition
afterload/preload reducer, improve survival. ↓ VR & TPR, ↑ SV & CO. No cough or edema.
Term
Furosemide (LAsix)
Definition
Loop diuretic, TX of Heart failure- most common. dec. volume--> dec preload/wall stress.
Term
Bumetanide (Bumex)
Definition
Loop diuretic, TX of Heart failure. dec. volume--> dec preload/wall stress.
Term
Torsemide (Demadex)
Definition
Loop diuretic, TX of Heart failure. dec. volume--> dec preload/wall stress.
Term
Chlorothiazide
Definition
Thiazide diuretic, TX of HF. dec. volume--> dec preload/wall stress.
Term
Spironolactone
Definition
K Sparing diuretic, TX of severe HF. least efficacious. prevents remodeling
Term
Nitroprusside
Definition
Vasodilator, afterload/preload reducer. ↓ VR and TPR. release NO in arteries and veins. HTN Crisis
Term
Catopril (Capoten)
Definition
ACE inhibitor, TX of HF. AE hypotension, renal insufficiency, elevated bradykinin
Term
Enlapril (Vasotec)
Definition
ACE inhibitor, TX of HF. AE hypotension, renal insufficiency, elevated bradykinin
Term
beta blockers in HF
Definition
Cardioprotective, ↓ TPR & VR, then ↓ HR, ↑ SV, antidysrhythmic action
Term
Carvedilol (Coreg)
Definition
A/B blocker, TX for HF. oral, 1st pass metabolism. AE- heart failure, HTN, bronchospasm
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