Term
|
Definition
nitrogen mustard- hodgkin (Mopp), cutaneous T-cell lymph
n/v, myelosupress |
|
|
Term
| cyclophosphamide and ifosfamide |
|
Definition
| mustards, prodrugs, long half life, CLL, nHL, breast, lung, ovarian ifosf-sarcoma and test. n/v, myelosupress, hemorrhagic cystiti- MESNA (sodium 20mercaptoethane sulfonate) inactivates acrolein |
|
|
Term
| carmustine, streptozocin, lomustine |
|
Definition
nitrosureas, alkylators, carm/lom- lipophilic->brain tumors
streptozocin- methylnitrosuourea- pancreatic and carcinoid
myelosupress, n/v, renal, pulm fibrosis |
|
|
Term
| decarbazine and temozolomide |
|
Definition
| alk, triaizines, decarb- prodrug, iv, temoz-pH change, oral decarb- abvD in HD, melanoma, temo- gliomas n/v, myelosupress, flu-like |
|
|
Term
|
Definition
| platinum- covalently bind, cross-link, cis- test, ovar, cerv, bladder, head/neck, lung. carbo-ovarian. oxali- gastric/colorectal cis- nephro, oto, n/v, motor/sens neuro, myelo carbo-myelo ox- cold peripheral neuro, neutropenia |
|
|
Term
|
Definition
| dhfr inh, childhood ALL and chroiocarc, Burkitt, breast, ovary, h/n, bladder, intrathecal for meningeal leuk/metastases, osteosarcoma myelo, gi - leucovorin- activated folic acid, taken up pref by normal cells, renal- crystals, hepato, reproductive resistance- reduced uptake, inc dhfr, decreased affinity |
|
|
Term
|
Definition
| folate analog- colon, mesothelioma, non-small lung, pancreatic |
|
|
Term
|
Definition
prodrug, inh thym synth, inc to RNA, IV due to GI tox, topical, breast, colrect, gastric, h/n, cerv, pancr
capecitabine- oral prodrug- breast, colorect
anorexia, naus, muc. ulcerations, thrombocytopenia/anemia, hand/foot synd, cardiac |
|
|
Term
|
Definition
dna term, AML, ALL and blastphase CML
sev myelo, GI |
|
|
Term
|
Definition
inh ribonucleotide reductase, inc to DNA, pancreatic, non-small lung, ovarian, bladder, esoph, h/n
myelo, flu-like |
|
|
Term
|
Definition
prodrug, inh de novo purine synth, in into dna/rna
ALL, allopurinol increases effective dose
myelo, hepato, resistance- reduced HGRPT- less conversion; decreased transport |
|
|
Term
| streptomyces DNA intercalating agents |
|
Definition
| dactinomycin, dano doxo epi ida rubicins, bleomycin |
|
|
Term
|
Definition
interc G-C, inh transcription, SS breaks. wilms', rhadomyosarc, ewings sarc, - kids tumors, advanced choriocarcinoma
anorexia, n.v, pancytopenia, |
|
|
Term
| dano doxo epi and idarubicins |
|
Definition
anthracyclines, superoxide, dna interc.
dano/id- aml, doxo-sarc, breast, lung, lymph, epi-breast, gastric
myelo, irr cardiotoxic, GI, alopecia |
|
|
Term
|
Definition
copper-chelating, dna breaks from oxidation, 2 peptides, test, squamous, lymph
myelo, pulm fib, cutaneous-hyperpig, hyperkerat, erythema; headache, n/v |
|
|
Term
| vinblastine and vincristine |
|
Definition
vinca alkaloids, block tub poly, m-phase arrest, blast-w/bleomycin and cisplatin for meta testicular, abVd in HD, crist- w/glucocort in kids ALL, HD and nHL
blast-myelo, n/v
crist- periph neuro, good wrt myelo |
|
|
Term
|
Definition
yew, prevent depoly, meta breast, ovar, lung, h/n, doc-hormone-refract prostate
neutropenia, per neuro, hypersens |
|
|
Term
|
Definition
epipodophyllotoxins, topoII, eto-test, lung, nHL. teni-ALL
dose-limit myelo, oral mucositis |
|
|
Term
|
Definition
camptothecins, topoI, irino-colorectal, lung, ovar, cerv, brain. topo- ovarian, small cell lung
severe neutropenia, diarrhea |
|
|
Term
|
Definition
pred- ALL, mopP and choP for HD and nHL, MM and CLL
dexamethasone- w.radiation to reuce edema in meninges |
|
|
Term
|
Definition
SERM, er-positive meta breast, prevention in high risk
hot flashes, alopecia, n/v, increased endom cancer, increased thromboembolic |
|
|
Term
|
Definition
| SERDownregulators, higher affinity than SERMs, postmenop w/meta breast |
|
|
Term
| aminoglutethamide and anastrozole |
|
Definition
| AIs, amino-first gen, sign toxicity, ana- 3rd gen, potent and selective, er+ breast in post menopause |
|
|
Term
|
Definition
| GnRH analogs, red testicular testosterone, prostate |
|
|
Term
| flutamide and bicalutamide |
|
Definition
| nonsteroidal AR blockers, prostate |
|
|
Term
|
Definition
| inh ribonucleoside diphosphate reductase, ribonuc to deoxyribo, CML, PV, ET, Sickle |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| alpha, hairy-cell leuk, CML, Kaposi's |
|
|
Term
|
Definition
inh Abl, PDGFR and c-kit, also for GIST
resistance- nutations in BcrAbl, enhanced binding to other proteins, efflux
relapse- mutants, amplification
Gists- relapse from liver and perit meta, |
|
|
Term
|
Definition
| EGFR tyr kinase, non-small lung |
|
|
Term
|
Definition
HER2/neu, meta breast
t:hypersens, ventr dys, enhance anthracyclin cardiotox |
|
|
Term
|
Definition
| ErbB1/EGFR1, meta colorectal, scchn, |
|
|
Term
|
Definition
|
|
Term
|
Definition
antidote- protamine sulfate
t:osteoporosis, does not cross placenta |
|
|
Term
|
Definition
binds to active site of antithrombin, 15 hr t1/2, no antidote
|
|
|
Term
| lepirudin and bivalirudin |
|
Definition
| leech hirudin, irreversible thrombin inhbit |
|
|
Term
|
Definition
arg analog, inh thrombin catalytic site, used in HIT,
superior to warfarin |
|
|
Term
|
Definition
| oral, comp inh of thrombin, standard dose |
|
|
Term
| rivaroxaban, apixaban, betrixaban |
|
Definition
| direct Xa inh, oral, predictable |
|
|
Term
| reteplase and tenectase vs streptokinase and urokinase |
|
Definition
| strepto/uro less selective to clot |
|
|
Term
|
Definition
| phosphodiesterase inh, increases cAMP, less aggregation |
|
|
Term
|
Definition
inh P2Y12 (ADP receptors), effective up to 10 days, only transfusion reversal
other in class: prasugrel- more potent, ticagelor- faster/reversible, cangrelor-IV |
|
|
Term
|
Definition
abciximab- immune response prevents repeated use
eptifibatide and tirofiban- fibrinogen analogs |
|
|
