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Chapters 5, 6, 12-14
Vocabulary & Key Concepts
254
Biology
Undergraduate 1
10/12/2013

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Term
why are ions less likely to be found within the cell membrane?
Definition
membrane inside is uncharged
Term
unsaturated fats & proteins = permeable or nonpermeable?
Definition
permeable
Term
saturate fats & cholesterol = permeable or nonpermeable?
Definition
nonpermeable
Term
are sister chromatids identical?
Definition
yes
Term
why does the digestive system have trouble digesting cellulose?
Definition
beta glycosidic linkages
Term
hypertonic solution
Definition
more solutes
Term
functional group associated with alcohol
Definition
hydroxide
Term
which has more energy?
~carbohydrate
~long carbon chain with carboxylic acid at the end
Definition
long carbon chain with carboxylic acid at the end
Term
the mass of DNA per cell after completion of meiosis II is _____ the mass of DNA per normal somatic cell
Definition
1/2
Term
the mass of DNA per cell after completion of meiosis II is _____ the mass present per cell after Interphase
Definition
1/4
Term
Interphase has _____ the mass of DNA per cell after Meiosis I
Definition
2x
Term
how many hydroxyl groups does every monosaccharide contain?
Definition
at least two
Term
what varies among polysaccharides?
Definition
location/geometry of glycosidic linkages
Term
if two organisms show a developmental homology, you would also definitely expect them to share _____
Definition
genetic homologies
Term
carbohydrates share the same _____ in some types of animals & in all plants
Definition
structural role
Term
Wallace
Definition
argued that variation among individuals allows evolution to occur
Term
which carbohydrate contains a peptide bond?
Definition
peptidoglycan
Term
AaBbCc x AABbCc = probability of AABBCC
Definition
1/32
Term
AaBbCc x AABbCc = probability of AaBbcc
Definition
1/16
Term
AaBbCcddEe x AABBccDDEe = probability of AaBBCcDdEE
Definition
1/32
Term
AaBbCcddEe x AABBccDDEe = probability of AABBCCDDee
Definition
0
Term
X'X x X'Y = probability of affected offspring
Definition
1/2
Term
X'X x X'Y = probability of unaffected female
Definition
1/4
Term
X'X x X'Y = probability of diseased male
Definition
1/4
Term
BbX'X x bbXY = probability of brown eyes
Definition
1/2
Term
BbX'X x bbXY = probability of blue eyes
Definition
1/2
Term
BbX'X x bbXY = probability of color blindness
Definition
1/4
Term
BbX'X x bbXY = probability of color-blind male
Definition
1/4
Term
BbX'X x bbXY = probability of brown eyed, color blind male
Definition
1/8
Term
BbX'X x bbXY = probability of blue eyed, color blind females
Definition
0
Term
BbX'X x bbXY = probability of any male being color blind
Definition
1/2
Term
why do males show sex-linked traits more often than females?
Definition
only have 1 X (doesn't matter that traits are recessive)
Term
mass of DNA in S phase
Definition
doubled
Term
mass of DNA in meiosis 1
Definition
normal
Term
mass of DNA in meiosis II
Definition
halved
Term
how do cyclins & cdks help regulate the cell cycle?
Definition
begin cell cycle by phosphorylating Rb
Term
what happens if Cdks fail to phosphorylate Rb?
Definition
no cell cycle replication will occur
Term
how many diploid cells are produced in meiosis?
Definition
0
Term
how many different genotypes are possible in the cross of Aabb X AaBb
Definition
6
Term
Aabb X AaBb = probability of aaBb
Definition
1/8
Term
Aabb X AaBb = probability of dominant phenotype of A & recessive phenotype for B
Definition
3/8
Term
pleotropy
Definition
when one gene alters many phenotypic traits
Term
example of pleotropy
Definition
sickle cell
Term
polygenic
Definition
when one trait is determined by multiple genes
Term
example of polygenic
Definition
epistasis
Term
cytokinesis in plants VS in animals
Definition
plants: microtubules direct vesicles to center of spindle where they fuse a new cell wall
animals: cells are pulled apart by actin & myosin proteins until they pinch off
Term
what phase comes after anaphase?
Definition
metaphase
Term
4 phases of the cell cycle
Definition
G1, S, G2, M
Term
smallest phase in the cell cycle
Definition
M phase (others involve checkpoints & replication)
Term
MPF
Definition
dimer consisting of cyclin & Cdk
Term
kinase
Definition
catalyzes phosphorylation of other proteins to starts M phase
Term
dimer
Definition
protein with 2 polypeptide subunites
Term
Rb protein
Definition
inactivates E2F by binding to it (tumor suppressor)
Term
G1 checkpoint
Definition
size & nutrients
Term
growth factors
Definition
extracellular signals tell cell to get ready to promote replication
Term
E2F
Definition
transcription factor (promotes gene transcription) only when activated (phosphorylated or released)
Term
what increases to drive the process of cell replication?
Definition
cyclin
Term
6 steps of G1 checkpoint
Definition
1. growth factors arrive from other cells
2. growth factors cause increase in cyclin & E2F concentrations
3. cyclin binds to Cdk; Cdk is phosphorylated. Rb inactivates E2F by binding to it
4. inactivating phosphate is removed, & active Cdk phosphorylates Rb
5. phosphorylated Rb releases E2F
6. E2F triggers production of S-phase proteins
Term
p53
Definition
prevents further activity when DNA is damaged
Term
difference between a chromosome and a gene
Definition
chromosome = larger structure that is made up of genes
Term
different stages of the cell cycle (and what they are)
Definition
G1/G0: normal function
S: DNA replication
G2: prep for division
M: cell division/reproduction
Term
phases of mitosis
Definition
interphase
prophase
prometaphase
metaphase
anaphase
telophase
cytokinesis
Term
phases of meiosis
Definition
interphase
early prophase 1
late prophase 1
metaphase 1
anaphase 1
telophase 1 & cytokinesis
prophase II
metaphase II
anaphase II
telophase II & cytokinesis
Term
cyclin
Definition
regulatory protein
Term
MPF
Definition
m phase-promoting factor made up of cyclin & cdk
Term
G1 control
Definition
size, nutrients, etc
Term
G2 control
Definition
DNA copied/complete & MPF
Term
M control
Definition
spindle attachment, chrom attachment, no MPF
Term
benefits of sex
Definition
evolutionary advantage, mixing & matching gene sequences for an uncertain future
Term
prophase 1
Definition
chromosomes condense, spindle apparatus forms, nuclear envelope broken down, synapsis of homologous chromosomes, chiasmata visible
Term
metaphase 1
Definition
migration of bivalents to metaphase plate is complete
Term
anaphase 1
Definition
homologs separate & begin moving to opposite poles of spindle apparatus
Term
aneuploidy
Definition
nondisjunction occurs (trisomy VS monosomy)
Term
how did Mendel refute the theory of blending inheritance
Definition
pure parents --> dominant phenotype F1 --> both types of F2
Term
aa X aa
Definition
100% homozygous recessive
Term
Aa X aa
Definition
50% heterozygous dominant
50% homozygous recessive
Term
Aa X Aa
Definition
25% homozygous dominant
50% heterozygous dominant
25% homozygous recessive
Term
AA X aa
Definition
100% heterozygous dominant
Term
AA x Aa
Definition
50% heterozygous dominant
50% homozygous dominant
Term
AA x AA
Definition
100% homozygous dominant
Term
"and" VS "or" genetics problems
Definition
events that could occur in more than one way (or order) = "OR" & their probabilities should be added (summed); sequential events should have their probabilities multiplied
Term
quantitative traits
Definition
additive; number of dominant alleles matters (ex. how red a kernel is)
Term
sex linkage
Definition
genes located on sex chromosomes
Term
linkage
Definition
two genes found on same chromosome
Term
incomplete dominance
Definition
heterozygotes have intermediate phenotype
Term
codominance
Definition
heterozygotes have phenotype of both alleles
Term
multiple allelism
Definition
in a population, more than two alleles present at a locus
Term
polymorphism
Definition
in a population, more than two phenotypes associated with a single gene are present
Term
pleiotropy
Definition
a single gene affects many traits
Term
gene-by-gene interaction
Definition
in discrete traits, the phenotype associated with an allele depends on which alleles are present at another gene
Term
gene-by-environment interaction
Definition
phenotype influenced by environment experienced by individual
Term
polygenic inheritance of quantitative traits
Definition
many genes are involved in specifying traits that exhibit continuous variation
Term
square on a pedigree
Definition
male
Term
circle on a pedigree
Definition
female
Term
have shaded in shape on a pedigree
Definition
carrier
Term
shaded in shape on a pedigree
Definition
affected
Term
triose
Definition
three-carbon sugars
Term
pentose
Definition
five-carbon sugars
Term
hexose
Definition
six-carbon sugars
Term
glucose VS galactose
Definition
depends on position of -OH on 4' C
glucose: pointing up
galactose: pointing down
Term
aldose VS ketose
Definition
depends on C=O position (middle or not)
aldose: not middle
ketose: middle
Term
alpha ring VS beta ring
Definition
alpha: H above OH on 1' C (V bond)
beta: OH above H on 1' C (A bond)
Term
starch
Definition
used for energy storage in plant cells (such as in potatoes); unbranched helix (amylose) or branched helices (amylopectin)
Term
glycogen
Definition
used for energy storage in animal cells (such as in liver & muscles); highly branched helices
Term
cellulose
Definition
used for structural support in cells walls or plants & many algae; parallel strands joined by hydrogen bonds
Term
chitin
Definition
used for structural support in the cell walls of fungi & the external skeletons of insects & crustaceans; parallel strands joined by hydrogen bonds
Term
peptidoglycan
Definition
used for structural support in bacterial cell walls; parallel strands joined by peptide bonds
Term
glycoproteins
Definition
inside of the cell; attached to transmembrane protein
Term
energy in C-C and C-H bonds VS energy in C-O bonds
Definition
free energy in C-C and C-H is much higher than in C-O so energy from sunlight is stored in C-H and C-C bonds
Term
triglycerides
Definition
glycerol linked by ester linkages to three fatty acids
Term
steroids
Definition
OH-steroid rings-tail
Term
phospholipids
Definition
hydrophilic head, hydrophobic tail
Term
permeability: saturated VS unsaturated
Definition
unsaturated = more permeable
Term
saturated VS unsaturated tails
Definition
saturated = straight
unsaturated = there is a C=C bond in the middle --> kinks
Term
effect of length of hydrocarbon tails on fluidity
Definition
short tails = higher fluidity
Term
cold weather = unsaturated or saturated tails?
Definition
unsaturated
Term
trans configuration in fats
Definition
alternating C-H bonds on either side of the C=C bond
Term
low density lipoprotein
Definition
transports cholesterol to tissues; oxidized --> set off an immune response that creates plaque in vessel walls = atherosclerosis --> ischemia
Term
high density lipoprotein
Definition
transports cholesterol to liver --> bile formation, decreasing cholesterol concentration in the blood
Term
diffusion
Definition
separation of solutes by lipid bilayer --> diffusion (with concentration gradient) --> equilibrium
Term
cell division
Definition
new cells arise by splitting preexisting cells
Term
embryos
Definition
developing organisms
Term
meiosis
Definition
leads to the production of sperm & eggs
Term
gametes
Definition
sperm & eggs
Term
mitosis
Definition
leads to the production of all other cell types besides gametes
Term
somatic cells
Definition
body-belonging cells
Term
cytokinesis
Definition
the division of the cytoplasm into two distinct cells
Term
3 requirements for cellular replication
Definition
1. copy the DNA
2. separate the copies
3. divide the cytoplasm to create two complete cells
Term
3 events that eukaryotic cell replication is responsible for
Definition
1. growth
2. wound repair
3. reproduction
Term
asexual production
Definition
produces offspring that are genetically identical with the parent
Term
chromosome
Definition
threadlike structures; consists of a single, long DNA double helix that is wrapped around proteins in a highly organized manner
Term
histones
Definition
the proteins around which the DNA double helix is wrapped in a chromosome
Term
chromatid
Definition
each of the DNA copies in a replicated chromosome
Term
centromere
Definition
specialized region of the chromosome that joins sister chromatids
Term
sister chromatids
Definition
chromatid copies that remain attached at their centromere
Term
M phase
Definition
mitotic/meiotic phase; cell dividing phase
Term
interphase
Definition
between phase
Term
cell cycle
Definition
the orderly sequence of events that leads a eukaryotic cell through the duplication of its chromosomes to the time it divides
Term
G1 phase
Definition
the gap between the end of M and start of S phase
Term
G2 phase
Definition
the second gap, between the end of S and start of M phase
Term
8 steps of mitosis
Definition
1. interphase: after chromosome replication, each chromosome is composed of two sister chromatids; centrosomes have replicated
2. prophase: chromosomes condense & spindle apparatus begins to form
3. prometaphase: nuclear envelope breaks down; microtubules contact chromosomes at kinetochores
4. metaphase: chromosomes complete migration to middle of cell
5. anaphase: sister chromatids separate into daughter chromosomes & are pulled to opposite poles of the spindle apparatus
6. telophase: the nuclear envelope re-forms & chromosomes de-condense
7. cell division begins: actin-myosin ring causes the plasma membrane to being pinching in
8. cell division is complete: two daughter cells form
Term
chromatin
Definition
the material that makes up eukaryotic chromosomes; consists of DNA molecule complexed with histone proteins
Term
kinetochores
Definition
the structures on sister chromatids where microtubules attach
Term
microtubule-organizing center
Definition
any structure that organizes microtubules
Term
centrosome
Definition
the microtubule-organizing center in animals & some plants
Term
centrioles
Definition
cylindrical structures that comprise microtubules, located inside animal centrosomes
Term
cell plate
Definition
a flattened sac-like structure formed by the vesicles in the middle of what was the spindle
Term
cleavage furrow
Definition
what cytokinesis begins with in animals & many other eukaryotes
Term
binary fission
Definition
how many bacteria divide
Term
M phase-promoting factor (MPF)
Definition
the factor that initiates m-phase in oocytes
Term
cyclin-dependent kinase (Cdk)
Definition
the protein kinase subunit of MPF
Term
negative feedback
Definition
when a process is slowed or shut down by one of its products
Term
tumor
Definition
a mass of cells
Term
p53
Definition
activates genes that either stop the cell cycle until DNA damage can be repaired or cause the cell's programmed controlled destruction
Term
apoptosis
Definition
a cell's programmed controlled destruction
Term
tumor suppressors
Definition
regulatory proteins like p53
Term
cancer
Definition
disease caused by cells that divide in an uncontrolled fashion, invade nearby tissues, & spread to other sites in the body
Term
malignant tumor
Definition
one that is cancerous
Term
benign tumors
Definition
masses of noninvasive cells
Term
growth factors
Definition
polypeptides or small proteins that stimulate cell division
Term
serum
Definition
the liquid portion of blood that remains after blood cells & cell fragments have been removed
Term
6 steps in the G1 checkpoint
Definition
1. growth factors arrive from other cells
2. growth factors cause increase in cyclin & E2F concentrations
3. cyclin binds to Cdk; Cdk is phosphorylated; Rb inactivates E2F by binding to it
4. inactivating phosphate is removed & active Cdk phosphorylates Rb
5. phosphorylated Rb releases E2F
6. E2F triggers production of S-phase proteins
Term
sperm
Definition
male reproductive cell
Term
egg
Definition
female reproductive cell
Term
fertilization
Definition
the process of uniting sperm & egg
Term
gametes
Definition
reproductive cells such as sperm & eggs
Term
meiosis
Definition
nuclear division that leads to a halving of chromosome number & ultimately to the production of sperm & egg
Term
sex chromosomes
Definition
X and Y chromosomes
Term
autosomes
Definition
non-sex chromosomes
Term
homologs
Definition
chromosomes that are the same size & shape
Term
gene
Definition
section of DNA that influences some hereditary trait in an individual
Term
allele
Definition
different versions of the same gene
Term
karyotype
Definition
the number & types of chromosomes present
Term
diploid
Definition
organisms that have two versions of each type of chromosome
Term
haploid
Definition
organisms whose cells contain just one of each type of chromosome
Term
haploid number
Definition
the number of distinct types of chromosomes in a given cell
Term
ploidy
Definition
the combination of the number of sets & n
Term
maternal chromosome
Definition
comes from the mother
Term
paternal chromosomes
Definition
comes from the father
Term
polyploid
Definition
species that have three or more of each type of chromosome in each cell
Term
unreplicated chromosome
Definition
a chromosome that consists of one double-helical molecule of DNA packaged with proteins
Term
replicated chromosome
Definition
a chromosome that has been copied; consists of two identical chromatids, each containing one double-helical DNA molecule
Term
sister chromatids
Definition
the two identical chromatid copies in a replicated chromosome
Term
non-sister chromatids
Definition
chromatids belonging to homologous chromosomes
Term
bivalent (or tetrad)
Definition
homologous replicated chromosomes that are joined together during prophase I & metaphase I of meiosis
Term
diploid number
Definition
the number of chromosomes present in a diploid cell; symbolized 2n
Term
gametogenesis
Definition
formation of egg cells or sperm cells
Term
zygote
Definition
the cell that results from fertilization
Term
life cycle
Definition
the sequence of events that occurs over the life span of an individual, from fertilization to the production of offspring
Term
10 steps of meiosis
Definition
1. interphase: uncondensed chromosomes replicate in parent cell
2. early prophase I: chromosomes condense, spindle apparatus forms, nuclear envelope begins to break down; synapsis (pairing) of homologous chromosomes
3. late prophase I: chiasmata (crossover points) visible, nuclear envelope broken down, often multiple chiasmata between non-sister chromatids
4. metaphase I: migration of bivalents to metaphase plate is complete
5. anaphase I: homologs separate & begin moving to opposite poles of the spindle apparatus
6. telophase I & cytokinesis: homologs separate & begin moving to opposite poles of the spindle apparatus
7. prophase II: spindle apparatus forms
8. metaphase II: chromosomes line up at the middle of the spindle apparatus (metaphase plate)
9. anaphase II: sister chromatids separate, begin moving to opposite poles of the spindle apparatus
10. telophase II & cytokinesis: chromosomes move to opposite poles of the spindle apparatus; spindle apparatus disassembles
Term
mitosis VS meiosis: number of cell divisions
Definition
mitosis: 1
meiosis: 2
Term
mitosis VS meiosis: number of chromosomes in daughter cells compared with parent cell
Definition
mitosis: same
meiosis: half
Term
mitosis VS meiosis: synapsis of homologs
Definition
mitosis: no
meiosis: yes
Term
mitosis VS meiosis: number of crossing-over events
Definition
mitosis: non
meiosis: one or more per pair of homologous chromosomes
Term
mitosis VS meiosis: makeup of chromosomes in daughter cells
Definition
mitosis: identical
meiosis: different - various combinations of maternal & paternal chromosomes, paternal & maternal segments mixed within chromosomes
Term
mitosis VS meiosis: role in organism life cycle
Definition
mitosis: asexual reproduction in some eukaryotes; cell division for growth
meisos: halving of chromosome number in cells that will produce gametes
Term
4 steps of prophase I
Definition
1. condensation
2. pairing
3. synapsis (bivalent formation)
4. partial separation of homologs
Term
heredity
Definition
inheritance, the transmission of traits from parents to offspring
Term
trait
Definition
any characteristic of an individual
Term
blending inheritance
Definition
the traits observed in a mother & father blend together to form the traits observed in their offspring
Term
inheritance of acquired characters
Definition
traits present in parents are modified through use & passed on to their offspring in the modified form
Term
model organism
Definition
a species that is used for research because it is practical & because conclusions drawn from studying it turn out to apply to many other species as well
Term
gene
Definition
a hereditary factor that influences a particular trait
Term
allele
Definition
a particular form of a gene
Term
genotype
Definition
a listing of the alleles in an individual
Term
phenotype
Definition
an individual's observable traits
Term
homozygous
Definition
having two of the same allele
Term
heterozygous
Definition
having two different alleles
Term
dominant allele
Definition
an allele that produces its phenotype in heterozygous & homozygous form
Term
recessive allele
Definition
an allele that produces its phenotype only in homozygous form
Term
pure line
Definition
individuals of the same phenotype that, when crossed, always produce offspring with the same phenotype
Term
hybrid
Definition
offspring from crosses between homozygous parents with different genotypes
Term
reciprocal cross
Definition
a cross in which the phenotypes of the male & female are reversed compared with a prior cross
Term
testcross
Definition
a cross between a homozygous recessive individual & an individual with the dominant phenotype but an unknown genotype
Term
X-linked
Definition
referring to a gene located on the X-chromosome
Term
Y-linked
Definition
referring to a gene located on the Y-chromosome
Term
autosomal
Definition
referring to a gene located on any non-sex chromosome (an autosome) or a trait determined by an autosomal gene
Term
principle of independent assortment
Definition
alleles of different genes are transmitted independently of one another
Term
wild type
Definition
most common phenotype for each trait
Term
disaccharides
Definition
when only two sugars are linked together
Term
glycosidic linkage
Definition
covalent interaction between two monosaccharides
Term
starch consists of _____
Definition
entirely alpha-glucose monomers joined by glycosidic linkages
Term
cell wall
Definition
a protective sheet that occurs outside the membrane
Term
cellulose consists of _____
Definition
beta-glucose monomers joined by beta 1,4 glycosidic linkages
Term
glycoprotein has one or more _____
Definition
carbohydrates covalently bonded to it
Term
photosynthesis
Definition
the process by which plants harvest the kinetic energy in sunlight & store it in the bonds of carbohydates
Term
phosphorylase
Definition
enzyme involved in catalyzing the hydrolysis of alpha-glycosidic linkages in glycogen molecules
Term
amylase
Definition
the enzymes involved in breaking the alpha-glycosidic linkages in starch
Term
hydrocarbons
Definition
molecules that contain only carbon & hydrogen
Term
fatty acid
Definition
a simple lipid consisting of a hydrocarbon chain bonded to a carboxyl (-COOH) functional group
Term
saturated
Definition
hydrocarbon chains that consist of only single bonds between the carbons
Term
unsaturated
Definition
if one or more double bonds exist in the hydrocarbon chains
Term
waxes
Definition
saturated lipids that have extremely long hydrocarbon tails
Term
fats
Definition
nonpolar molecules composed of three fatty acids that are linked to a three-carbon molecule (glycerol)
Term
oils
Definition
liquid triacylglycerols formed when fatty acids are polyunsaturated
Term
ester linkage
Definition
bond between glycerols & fatty acids
Term
steroids
Definition
family of lipids distinguished by the bulky, four-ring structure
Term
phospholipids
Definition
a glycerol that is linked to a phosphate group & two hydrocarbon chains of either isoprenoids or fatty acids
Term
amphipathic
Definition
compounds that contain both hydrophilic & hydrophobic elements
Term
lipid bilayer
Definition
when two sheets of lipid molecules align
Term
permeability
Definition
tendency to allow a given substance to pass through it
Term
selective permeability
Definition
some substances can cross a membrane more easily than others
Term
solutes
Definition
all dissolved molecules & ions
Term
diffusion
Definition
movement of molecules & ions that results from their kinetic energy
Term
osmosis
Definition
the movement of water
Term
hypotonic
Definition
water leaves (less solutes)
Term
hypertonic
Definition
water enters (more solutes)
Term
isotonic
Definition
water doesn't move (equilibrium)
Term
protocells
Definition
simple vesicle-like structures that harbor nuclei acids
Term
peripheral membrane proteins
Definition
proteins that bind to the membrane without passing through it
Term
detergent
Definition
a small amphipathic molecule
Term
aquaporins
Definition
channels that allow water to cross the plasma membrane
Term
passive transport
Definition
powered by diffusion along an electrochemical gradient
Term
facilitated diffusion
Definition
the passive transport of substances that otherwise would not cross a membrane readily
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