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Chapter 9
Schizophrenia and Related Disorders
122
Psychology
Undergraduate 4
04/04/2011

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Term
schizophrenia
Definition
range of symptoms involving disturbances in content of thought, form of thought, perception, affect, sense of self, motivation, behavior, and interpersonal function
Term
schizophrenia prevalence
Definition
one percent of adult population
Term
estimated cost of schizophrenia in united states
Definition
billions per ear not including indirect cost such as family care giving and lost income
Term
benedict morel
Definition
first identified schizo as disease
Term
emil kraepelin
Definition
german psychiatrist who systematically defined schizo as dementia praecox and believed that hallucinations, delusions, and bizarre behavioral disturbances seen in people with schizo could ultimately be traced to physical abnormality
Term
dementia praecox
Definition
degeneration of the brain (dementia) that began at relatively young age (praecox) and ultimately led to disintegration of the entire personality
Term
eugen bleuler
Definition
coined term schizophrenia (a splitting (schiz) or lack of integration among the individuals psychological functions
Term
bleuler's four a's
Definition
association, affect, ambivalence, and autism
Term
association
Definition
thought disorder, as might be evident through ramblin and incoherent speech
Term
affect
Definition
disorder of the experience and expression of emotion
Term
ambivalence
Definition
inability to make or follow through on decisions
Term
autism
Definition
idiosyncratic style of egocentric thought and behavior
Term
kurt schneider
Definition
first-rank symptoms
Term
first-rank symptoms
Definition
hearing voices that comment on one's actions and believing that an outside agent is inserting thoughts into one's mind once thought by schneider as a must for the diagnosis of schizo but is no longer considered valid
Term
phases of schizo
Definition
active, prodromal, residual
Term
diagnosis of schizo
Definition
disturbance that lasts at least 6 months and includes at least 1 month of active symptoms including at least two out of delusions, hallucinations, disorganized speech, disturbed or catatonic behavior, and negative symptoms
Term
active phase
Definition
delusions, hallucinations, disorganized speech, disturbed behavior, and negative symptoms
Term
negative symptoms
Definition
speechlessness or lack of initiative
Term
prodromal phase
Definition
period prior to active phase during which the individual shows progressive deterioration in social and interpersonal functioning characterized y maladaptive behaviors
Term
maladaptive behaviors of prodromal phase
Definition
social withdrawal, inability to work productively, eccentricity, poor grooming, inappropriate emotionality, peculiar thought and speech, unusual beliefs, odd perceptual experiences, decreased energy and initiative
Term
residual phase
Definition
follows active phase in which there are continuing indications of disturbance similar to the behaviors of the prodromal phase
Term
2 identifiers in young at risk individuals
Definition
CASIS cluster and positive symptoms
Term
CASIS cluster
Definition
cognitive deficits (C), affective disturbances (A), social isolation (SI), and school failure (S) 
Term
positive symptoms
Definition
exaggerations or distortions of normal thoughts, emotions, and behavior also thought of as direct lead-ins to the full expression of psychosis
Term
5 Symptoms of Schizo
Definition
delusions, hallucinations, disorganized speech, disturbed behavior, negative symptoms
Term
disturbance of thought: delusions
Definition
deeply entrenched false beliefs and most common disturbance of thought content associated with schizo
Term
9 Types of Delusions
Definition
grandeur, control, reference, persecution, self-blame, somatic, infidelity, thought broadcasting, thought insertion
Term
grandeur
Definition
exaggerated conception of individuals own importance
Term
control
Definition
feeling that one is being controlled by others, machines, appliances
Term
reference
Definition
belief that the behavior of others or certain objects or events are personally referring to oneself
Term
persecution
Definition
another person is truing to inflict harm on them or their family or social group when they really aren't
Term
self-blame
Definition
feelings of remorse without justification
Term
somatic
Definition
inappropriate concerns about one's own body, typically related to disease
Term
infidelity
Definition
false belief usually associated with pathological jealousy involving the notion that ones lover is being unfaithful
Term
thought broadcasting
Definition
ones thought are being broadcasted to others
Term
thought insertion
Definition
thoughts are being inserted into ones mind by outside forces
Term
4 delusions most common to schizo
Definition
grandeur, broadcasting, persecution, reference
Term
disturbances in perception: hallucinations
Definition
false perceptions involving one of the five senses that do not correspond to actual stimuli but are real to the person with schizo
Term
disturbances in thinking, language, and communication: disorganized speech
Definition
thinking that lacks cohesiveness and logic and language that can be grossly distorted to the point of incomprehensibility but can also be less dramatic as in the use of awkward or pompous-sounding speech
Term
disturbed or catatonic behavior
Definition
moving in odd ways or displaying catatonic behavior
Term
3 types of cantonic behavior
Definition
stupor, rigidity, excitement
Term
catatonic stupor
Definition
unresponsive to external stimuli, possibly to the point of being unaware of one's surroundings
Term
catatonic rigidity
Definition
stiffened posturing of the body and resistance to pressure to move
Term
catatonic excitement
Definition
purposeless and repetitive bodily movements
Term
negative symptoms
Definition
symptoms that involve funcitoning below the level of behavior regarded as normal
Term
3 most common negative symptoms
Definition
affective flattening, alogia, avolition
Term
affective flattening
Definition
unresponsive with relatively motionless body language and facial reactions and minimal eye contact
Term
alogia
Definition
loss of words or notable lack of spontaneity or responsiveness in conversation
Term
avolition
Definition
lack of initiative and unwillingness to act such as staring out the window instead of doing anything else
Term
anhedonia
Definition
negative symptom characterized by loss of interest in or ability to experience pleasure from activities that most people find appealing
Term
social and occupation dysfunction
Definition
troubled interactions with relatives, acquaintances, strangers particularly during active phase as well as the fact that others see such behaviors as odd and so shun schizos because being around them is confusing and uncomfortable resulting in social isolation and an increased intensity of disorder
Term
5 types of schizo
Definition
catatonic type, disorganized type, paranoid type, undifferentiated type, residual type
Term
catatonic type
Definition
prominent symptom is bizarre motor behaviors
Term
disorganized type
Definition
combination of symptoms including disorganized speech, disturbed behavior, and flat or inappropriate affect - even persons delusions and hallucinations lack coherent theme - noticeably odd in behavior and have serious impairment in work and other social contexts
Term
paranoid type
Definition
preoccupied with one or more bizarre delusions or have auditory hallucinations related to theme of being persecuted or harassed - no disorganized speech or disturbed behavior - hallucinations related to content of delusions but cognitive functioning and affect are reasonably normal - interpersonal problems because of suspicions
Term
undifferentiated type
Definition
mixed symptoms making it difficult for clinician to place client into other schizo category
Term
residual type
Definition
not delusional, hallucinating, incoherent, or disorganized but retain symptoms such as emotional dullness, social withdrawal, eccentric behavior, or illogical thinking
Term
three-factor dimensional
Definition
psychotic (factor 1), negative (factor 2), and disorganized (factor 3)
Term
the need for three-factor dimensional model
Definition
because of the limited value of the schizo subtypes in clinical and research settings
Term
psychotic factor
Definition
individual experiences prominent delusions and hallucinations
Term
negative factor
Definition
conditions characterized by negative symptoms (affective flattening, alogia, avolition)
Term
disorganized factor
Definition
disorganized speech, disorganized behavior, and inappropriate affect
Term
courses of schizo
Definition

serious (continuous positive symptoms with no remission), episodes of positive symptoms with only negative symptoms in between, single episodes without another recurrence of disorder (remission)

 

Term
broad list of 15 factors associated with more favorable prognosis in people with schizo
Definition
adjustment prior to onset, acute onset, later age at onset, good insight, female, precipitating event associated with onset, presence of associated mood disturbance, medication soon after onset, compliance with medication recommendations, brief duration of active-phase symptoms, good functioning between episodes, absence of structural brain abnormalities, normal neurological functions, fam history of mood disorders, no fam history of schizo
Term
gender and age development and prevalence of late onset and gender
Definition
  • men more likely to develop disorder between ages 18 and 25 - women more likely to develop disorder between 25 and mid-thirties
  • 3 to 10 percent of women have onset after age 40 whereas men are not as likely to have such late onsets
Term
gender and symptoms
Definition
  • women more likely to have paranoid delusions, hallucinations,and intense affective symptoms
  • men more likely to experience neg symptoms such as flat affect and social withdrawal
Term
5 other psychiatric disorders
Definition
brief psychotic disorder, schizophreniform disorder, schizoaffective disorder, delusional disorders, shared psychotic disorder
Term
brief psychotic disorder - "nervous breakdown"
Definition
characterized by a sudden onset of psychotic symptoms that lasts less than a month
Term
trigger of symptoms of brief psychotic disorder
Definition
"stressors or often reactive symptoms appearing after stressful event or set of events and eventually the person returns to normal functioning
Term
3 types of stressors associated with brief psychotic disorder
Definition
marked, without marked, or with postpartum onset
Term
common behavior found in brief psychotic disorder behavior
Definition
individuals may act in ways that are completely uncharacteristic of their premorbid personality, failing to take care of themselves or interacting with others in ways that are incomprehensible to those who care about them - suicidal thoughts not uncommon
Term
3 treatments of brief psychotic disorder and 2 related general types of medication
Definition
short-term use of antianxiety or anti-psychotic meds to help  return to normal functioning, dependent upon the nature of the stressor, psychotherapy
Term
2 diagnostic features of brief psychotic disorder
Definition
  • for at least 1 day, but less than 1 month, individuals experience one of the symptoms of delusion, hallucination, disorganized speech, or grossly disturbed or catatonic behavior
  • condition can be specifies as being one with marked stressor, unmarked stressor, or postpartum onset
Term
schizophreniform disorder
Definition
psychotic symptoms essentially the same as those found in schizo except for duration
Term
3 treatments for schizophreniform disorder and 1 related general type of medication
Definition
antipsychotic medication for the acute phase of disorder followed by steady weaning off medication, electroconvulsive therapy in cases which symptoms are dangerously out of control, psychotherapy
Term
1 diagnostic criteria for shcizophreniform disorder
Definition
  • one episode (at least 1 month but less than 6 in duration) of at least two of the schizo symptoms of delusion, hallucination, disorganized speech, disturbed or catatonic behavior, negative symptoms
Term
schizoaffective disorder
Definition
people who experience either a major depressive episode, a manic episode, or a mixed episode at the same time that they meet the diagnostic criteria for schizophrenia
Term
2 treatments of schizoaffective disorder and 3 related medications
Definition
trial and error of medications such as lithium, antidepressants, and antipsychotic medication (alone or combined), individualized psychotherapy
Term
3 diagnostic features of schizoaffective disorder
Definition
  • uninterrupted period of disturbance having major depressive episode, manic episode, or mixed episode concurrent with two of the schizo symptoms discussed in prior diagnostic criteria
  • during period of disturbance person has experienced delusions or hallucinations for at least 2 weeks in the absence of mood symptoms
  • mood episode symptoms are present for significant portion of duration of active and residual periods of disturbance
Term
delusional disorders
Definition
single striking psychotic symptom - an organized system of nonzero false beliefs (hallucinations are not prominent and do not show symptoms that would make diagnosis of schizo or mood disorder appropriate)
Term
5 types of delusional disorder
Definition
erotomanic, grandiose, jealous, persecutory, somatic
Term
erotomanic
Definition
delusion that another person, usually of great prominence, is deeply in love with them
Term
grandiose
Definition
delusion that one is an extremely important person
Term
jealous
Definition
the belief that one's sexual partner is being unfaithful
Term
persecutory
Definition
believe they are being harassed or oppressed
Term
somatic
Definition
belief that they have dreaded disease or that they are dying
Term
5 diagnostic criteria of delusional disorder
Definition
  • have non-bizarre delusion lasting at least 1 month
  • never had schizo symptoms other than possible tactile or olfactory hallucinations related to delusional theme
  • functioning not impaired/behavior not bizarre
  • if mood disturbances have occurred concurrent with delusions, duration brief
  • five types previously learned
Term
shared psychotic disorder
Definition
one or more people develop a delusional system as a result of a close relationship with a psychotic person who is delusional in which disorder develops in context of relationship with history of pathological dependence where nonpsychotic person gets caught up in delusional system of psychotic person and becomes equally consumed ny irrational belief
Term
folie a deux (folly of two)
Definition
term used to refer to pair sharing disorder
Term
1 diagnostic criteria of shared psychotic disorder
Definition
  • appropriate in cases in which a person develops a delusion similar to an already established delusion held by a person with whom he or she shares a close relationship
Term
schizophrenic spectrum disorders
Definition
refers to schizophrenic-like conditions ranging from some of the personality disorders to certain psychotic disorders
Term
2 extremes ends of schizophrenic-spectrum disorders
Definition
schizophrenia and mood disorders with psychotic features being at the two extremes
Term
3 betweens of schizophrenic-spectrum disorders
Definition
schizotypal personality disorder, other psychoses without prominent mood features, and schizoaffective disorder
Term
2 categories accounting for origin of schizo
Definition
biological and psychological
Term
3 biological perspectives
Definition
brain structure and function, genetics, biological stressors and vulnerability
Term
abnormalities in volume of brain cause
Definition
enlarged ventricles often accompanied by cortical atrophy
Term
cortical atrophy
Definition
wasting away of brain tissue
Term
2 locations of decreased brain volume
Definition
prefrontal lobes (planning and inhibiting thoughts) and temporal lobes (processesing auditory info)
Term
dopamine hypothesis
Definition
delusions, hallucination, and attentional deficits found in schizo can be attributed to overactivity of neurons communicating with each other via the transmission of dopamine
Term
specific dopamine receptor in cases involving later age of onset
Definition
D2
Term
genetic factor
Definition
closer a relative is to an individual with schizo, the greater the likelihood of concordance (identical twins highest concordance at close to 48 percent)
Term
chromosome 22 deletion syndrome and other possible related gene
Definition
people with condition are missing basic genetic info in particular area near middle reagion of chromosome 22 and possible related to psychotic symptoms, impairments in cognition, and communication deficits associated with schizo - chromosome 5 (responsible for transport of neurotransmitters including serotonin)
Term
endophenotypes
Definition
bio-behavioral abnormalities linked to genetic and neurobiological causes of mental illness or heritable traits that are not direct symptoms of the disorder (delusion or hallucination) but have been found to be associated with the condition
Term
biological stressors
Definition
prenatal period and delivery
Term
diathesis-stress model and Paul Meehl term "schizotypy"
Definition
individuals inherit vulnerability to schizo, expressed when individual is exposed to stressors from environment
Term
electrophysiological functioning and testing cognitive functioning
Definition
used to identify which individuals have inherited a vulnerability to schizo
Term
3 methods of testing electrophysiological functioning
Definition
smooth pursuit eye movements, antisaccade eye movements, sensory gating
Term
smooth pursuit eye movements and implication
Definition
  • visually follow targets such as small point of light on dark background while eye movements records eye movement
  • schizo show irregular pursuit of moving target along with interruptions by extraneous eye movements
Term
antisaccade eye movements and implications
Definition
  • look in direction opposite side of stimulus
  • poorer performance of those in the acute stage of schizo
Term
sensory gating and implications
Definition
  • repeated presentation of auditory stimulus and measuring evoked brain potentials
  • schizo do not show sensory gating effect meaning they are more likely to have difficulty filtering out irrelevant distractions
Term
continuous performance test and implications
Definition
  • when certain target stimulus displayed individual makes response and is presented with other stiuli at random
  • people with schizo do poorly
Term
8 potential influences on cognitive impairment
Definition
pathophysiology (illness-related brain disturbance), genes, chronic stress and distress, medication, education, gender, sociocultural influences, content and structure of cognitive task itself
Term
3 sociocultural perspectives
Definition
family systems, social causation hypothesis, downward social drift hypothesis
Term
expressed emotion (ee) and implications
Definition
  • provides a measure of the degree to which family members speak in ways that reflect criticism, hostile feelings, and emotional overinvolvement or overconcern
  • high in ee more likely to suffer relapse
Term
social causation hypothesis
Definition
membership in lower ses may actually cause schizo as they experience numerous economic hardships and are often denied access to benefits such as education, health care, and employment
Term
social drift hypothesis
Definition
downplays effects of ses and presumes schizo develops at equal rates cross social, cultural, and economic backgrounds and once people develop it their ses declines because the symptoms of schizo prevent them from economic success
Term
biological treatment general medication category and 6 examples
Definition
antipsychotics (aka neuroleptics) with sedating qualities such as thorazine, mellaril, stelazine, navane, haldol, prolixin
Term
tardive dyskinesia
Definition
affects 10 to 20 percent of people who take neuroleptics for a year or more and causes uncontrollable movements in various parts of the body including mouth, tongue, lips, fingers, arms, legs, and trunk
Term
5 examples of second-generation antipsychotics (aks "atypical antipsychotics")
Definition
clozaril, solian, risperdal, zyprexa, serlect
Term
major psychological perspective
Definition
behavioral
Term
2 major examples of behavioral therapy used in treating schizo
Definition
token economy, social skills training
Term
2 major examples of sociocultural treatments
Definition
milieu therapy, assertive community treatment (act)
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