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Chapter 9-11
Lenoir-Rhyne Microbiology Dr. Lutz
58
Biology
Undergraduate 1
03/10/2008

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Term
Penivillin V
Definition
Source: natural
Common uses: oral penicllin (acid stable)
Term
Peniciliin G
(benzylpencillin)
Definition
Source: natural
Term
Cloxacillin
Definition
Source: semisynthetic
Common uses:treatment of infections cause by penicllinase- producing staphylocci. Can be given orally.
Term
Methicillin
Definition
Source: semisynthetic
Common uses:treatment of infections cause by penicllinase- producing staphylocci.
Term
Ampicillin
Definition
Source: semisynthetic
Common uses:treatment of infections cause by penicllinase- producing staphylocci.
Term
Ticarcillin
Definition
Source: semisynthetic
Common uses: used to treat pseudomonas infections
Term
Carbenicillin
Definition
Source: semisynthetic
Common uses: used to treat pseudomonas infections
Term
Piperacilin
Definition
Source: semisynthetic
Common uses: used in treatment of gram-negative bacterial infections
Term
Chemotherapeutic agent
Definition
a chemical agent used to treat diseases
Term
selective toxicity
Definition
the quality possessed by a substance that can damage or destroy a living organism in the presence of another organism that remains unaffected.
Term
antibiotic resistance
Definition
a condition in which a microbe is unaffected by the presence of a compound used for antimicrobial therapy.
Term
hypersensitivity
Definition
an immune response that causes an individual to overreact to the presence of an antigen, resulting in an allergic condition
Term
antibiotic
Definition
antimicrobial agent that is the natrual product of living organisms
Term
antimicrobial
Definition
capable of killing or stopping the growth of a microbe
Term
competitive inhibitor
Definition
a compound that competes with a substrate for position at the active site on an enzyme, but that cannot be changed by the enzyme. These compound prevent normal essential enzyme funciton
Term
active site
Definition
that portion of an enzyme where the substrate binds
Term
parenteral
Definition
given into the body by injection or through a catheter
Term
broad spectrum
Definition
effective against more than one kind of bacterium; usually suggesting antibacterial activity against both grams-positive and gram-negative bacteria
Term
combination therapy
Definition
treatment with more than one antibiotic at a time
Term
prophylaxis
Definition
use of an antimicrbial to prevent infection from occuring
Term
osteomyelitis
Definition
microbial infeciton of bone
Term
endocarditis
Definition
infection of the tissues lining the inside of the heart or valves in the heart
Term
topical
Definition
applied locally such as to the sruface of the skin.
Term
systemic
Definition
referring to a body wide infection
Term
mycotic
Definition
referring to a fungal infection or disease
Term
Mode of action of Penicillins
Definition
Representative: Ampicillin
Action: inhibits peptidoglycan synthesis; activates autolytic enzymes
Term
Mode of action of Cephalosporins
Definition
Representative:Cephalothin
Action:Inactivates peptidoglycan synthesis
Term
Mode of action of Chloramphenicol
Definition
Representative: Chloramphenicol
Action:Blocks protein synthesis by inhibiting peptidyl transferase
Term
Mode of action of Macrolides
Definition
Representative:Erythromycin
Action: inhibits protein synthesis by blocking translocation reaction
Term
Mode of action of Tetracyclin
Definition
Representative:Doxyclycline
Action:Inhibits protein synthesis by inhibiting aminoacyl-tRNA binding to 30S ribosomal subunit
Term
Mode of action of Glycopeptide
Definition
Representative:Vancomycin
Action:Blocks early cell wall synthesis
Term
Mode of action of Quinolones
Definition
Representative:Ciprofloxacin
Action:Inhibits DNA gyrase enzyme; prevents unfolding and refolding of DNA
Term
Mode of action of Polymyxins
Definition
Representative:Polymyxin B
Action: Prevents membrance transport functions
Term
Mode of action of Aminoglycosides
Definition
Representative:Amikacin
Action:Prevents proein synthesis by interfering with 30 S ribosome funciton
Term
Empirical therapy
Definition
Treatment given on the basis of experience and not as a result of susceptibility testing.
Term
histamine
Definition
an important chemical mediator of both the inflammatory response and allergies
Term
humoral immunity
Definition
defenses involving anitbodies that attack microbes in the body fluids
Term
Chemotaxis
Definition
movement of a cell toward a chemical influence
Term
electophoresis
Definition
a technique used to seperate proteins or nucleic acids using an elctrical field
Term
globulin
Definition
a group of proteins foud in human serum
Term
megakaryocyte
Definition
giant multinucleated cell from which platelets arise
Term
sinusoid
Definition
a samll open cavity through which body fluids travel
Term
axillary
Definition
referring to the armpit
Term
inguinal
Definition
referring to the body region near the junction of trunk and thighs
Term
Immunity
Definition
All of the mechanisms used by the body as protection agains microorganisms and other foreign agents
Term
Innate immunity
Definition
inborn or natural immunity; mechanisms of resistance to infectino that are not acquired after birth
Term
Virulence factor
Definition
a structural or physiological character that enables a microbe to cause infection and disease
Term
Pathogenic
Definition
referring to the ability to cause disease
Term
sebaceous gland
Definition
a skin structure that secretes oily substances
Term
epithelium
Definition
a cellular layer covering internal and external body suraces that lacks blood vessels
Term
mucus
Definition
a thick secretion produced by mucous cells that covers mucous membranes
Term
seminal fluid
Definition
a secretory fluid that carries sperm
Term
acute inflammatory response
Definition
immediate mechanisms by which host defenses wall off or destroy invading microbes and repair damaged tissue
Term
macrophage
Definition
a white blood cell found in tissues that phagocytizes foreign material
Term
amoeboid
Definition
referring to a crawling movement by certain celss
Term
thymus
Definition
an endocrine gland located behind the breastbone near the throat
Term
phagocytosis
Definition
a process by which cells ingest particulate matter from their enviornment
Term
lymph
Definition
a fluid collected from tissues fo the body and transported in lymphatic ducts to the venous blood
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