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Chapter 7: Nerve Cells and Electric Signaling
N/A
54
Physiology
Undergraduate 2
10/16/2013

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Term
Central Nervous System
Definition
Consists of the brain and the spinal cord
Term
Peripheral Nervous System
Definition
Neurons that provide communication between neurons and effector organs
Term
What are the two divisions of the PNS?
Definition
Afferent

Efferent
Term
Afferent
Definition
Transmits sensory and visceral info from the organs to the central nervous system
Term
Efferent
Definition
Transmits info from the central nervous system to the effector organs
Term
What are the two sub-classes of the efferent division?
Definition
Somatic Nervous Sytem

Autonomic Nervous System
Term
What two branches can the autonomic nervous system be divided into?
Definition
Sympathetic nervous system

Parasympathetic nervous system
Term
What are the two types of cells in the nervous system?
Definition
Neurons

Glial
Term
Neuron
Definition
Excitable cell capable of communicating through eletrical impulses
Term
Glial Cell
Definition
Non excitable cell

Accounts for 90% of NS

Provide various types of support to the neurons
Term
Cell body
Definition
Soma
Term
Dendrites
Definition
Branch from the cell body and receive input from other neurons at synapses
Term
Synapse
Definition
Specialized junction in which neuron communication takes place
Term
Axon
Definition
Tail-like branch that comes off of cell body and transmits signals to other cells
Term
Collaterals
Definition
Branches that extend from an axon
Term
Action Potential
Definition
A brief, large change in membrane potential in which the inside of the cell becomes positively charged comapred to the negative charge outside the cell
Term
Axon Hillock
Definition
Site where the axon originates from the body

Initiation site of action potentials
Term
Axon Terminal
Definition
End of the axon

Site where the neurotransmitters are released from
Term
Postsynaptic cell
Definition
Neuron receiving the neurotransmitter
Term
Presynpatic Cell
Definition
Neuron whose axon terminal released the neurotransmitter
Term
Anterograde transport
Definition
Mechanism for moving products from cell body to the axon terminal
Term
Retrograde transport
Definition
Mechanism for moving products from the axon terminal two the cell body

Two types:
Slow axonal transport
Fast axonal transport
Term
Microtubules
Definition
Extend down the axon and function as tracks for transport molecules
Term
Kinesin
Definition
Protein that carries vesicles down the axon tracks
Term
Leak Channels
Definition
Found in Plamsa Membrane throughout neuron

Always open
Term
Ligand-gated channels
Definition
Open or close in response to the binding of a chemical to a receptor in the plasma membrane of a neuron

Located in dendrites and cell body
Term
Voltage-gated channels
Definition
Open and close in response to changes in membrane potential

Located throughout the neuron, specifically axon hillock
Term
What are the three types of neurons?
Definition
Bipolar

Pseudo-Unipolar

Multipolar
Term
Bipolar Neuron
Definition
Sensory neurons that have one axon and one denrite coming off of the cell body
Term
Pseudo-Unipolar Neuron
Definition
Subclass of Bipolar neuron in which the axon and dendrite appear as one process coming off of the cell body

Makes up most sensory neurons
Term
Multipolar Neuron
Definition
Most common neuron

Multiple projections coming off of the cell body
Term
What are the three functional classes of neurons?
Definition
Efferent

Afferent

Interneurons
Term
Efferent Neuron
Definition
Transmits info from CNS to effector organs
Term
Afferent Neurons
Definition
Transmit info from sensory receptors or visceral receptors to the CNS
Term
Interneurons
Definition
Account for almost all neurons in the body

Located ONLY in the CNS

Receive and process info from afferent neurons and relay it to efferent neurons
Term
Ganglion
Definition
Cell bodies of neurons that are clustered together in the PNS
Term
Nerves
Definition
Bundles of axons
Term
What are the four types of glial cells?
Definition
Astrocytes

Microglia

Oligodendrocytes

Schwann cells
Term
Myelin
Definition
An insulating layer that covers the axon and allows for more rapid signals

Made up of oligodendrocytes in the CNS

Made uip of Schwann cells in the PNS
Term
Nodes of Ranvier
Definition
Gaps in the myelin sheath that contain voltage-gated sodium and potassium pumps
Term
Resting Membrane Potential
Definition
The difference between the inside of cell body which is negatively charged (due to potassium) and the outside of the cell is positively charged (due to sodium)
Term
What is RMP? (volts)
Definition
-70mV
Term
Graded Potential
Definition
Small changes in membrane potential (electrical signals) that occur when ion channels open or close in response to a stimulus

Decremental (diminish in size with distance)

Travel short distance
Term
How can graded potentials become action potentials?
Definition
If a high frequency of graded potentials add up and depolarize a neuron to the threshold level
Term
Excitatory
Definition
Graded potentials that depolarize
Term
Inhibitory
Definition
Graded potentials that hyperpolarize
Term
What are the two types of summation?
Definition
Temporal 

Spatial
Term
Temporal summation
Definition
Occurs when a stimulus is applied in rapid succession such that the graded potential from the first application doesn't dissipate before the next graded potential occurs.
Term
Spatial Summation
Definition
The effects of stimuli from different sources occuring close together in time sum.
Term
All-or-None Principle
Definition
If the membrane is not depolarized to threshold, no action potential occurs
Term
What are the two types of refractory periods?
Definition
Absolute refractory period

Relative refractory period
Term
Absolute refractory period
Definition
Spans all of the depolarization phase plus most of the repolarization phase of an action potential.

During this time, a second action potential cannot be generated
Term
Relative Refractory Period
Definition
Occurs immediately after the absolute-refractory period.

Possible to generate a second action potential only if stimulus is stronger than that needed to reach threshold under resting conditions
Term
Saltatory Conduction
Definition
Jumping of action potential from node to node on the myelin sheath
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