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Chapter 6
The Endocrine System
55
Physiology
Undergraduate 1
02/08/2010

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Term
Primary endocrine organs
Definition
Hypothalamus thymus
pituitary gland adrenal glands
pineal gland pancreas
thyroid gland gondads
parathyroid glands placenta
Term
Seconday endocrine glands
Definition
heart small intesting
liver kidney
stomach skin
Term
Hypothalamus location
Definition
Located near the center of the head below the thalamus Connected to pituitay by a stalk called the infundibulum
Term
Relationship with posterior pituitary
Definition
the hypothalamus has neurons eith axons projecting into the posterior pituitary
Term
The neural endings in the posterior pituitary gland secrete two peptide hormones
Definition
ADH - anti-diuretic hormone
Oxytocin
Term
ADH
Definition
causes the kidneys to keep more water in the blood, instead of losing it into the urine - the kidnys main job is to make urine from blood
Term
Oxytocin
Definition
stimulated milk release from mammary glands
stimulates uterine contactions during pregnancy
Term
Portal System
Definition
when two capillary beds occure in series, without a trip to the heart in between
Term
tropic Hormone
Definition
any hormone that affects the release of another hormone (either positively or negatively)
Term
Prolactin
Definition
1)stimulated breast development durin pregnancy, and milk production
2) The secretion levels of prolactin are regulated by prolactin releasing hormone PRH and PIH
Term
Thyroid stimulating hormone
Definition
TSH- stimulated thyroid gland to release thyroid hormones (TH)
TSH secretion is stimulated by thyrotropin releasing hormone (TRH)
Term
TSH release is controlled by what
Definition
a tropic Release hormone (TRH)

TRH -> TSH -> TH
Term
Adrenocorticotropic hormone (ACTH)
Definition
1) stimulates secretion of glucocorticoids (primarily cortisol) by the adrenal cortex of teh adrenal gland
Term
ACTH secretion is stimulated by
Definition
corticotropin releasing hormone (CRH)

CRH -> ACTH - > glucocorticoids
Term
Growth hormone (GH)
Definition
Regulates growth and energy metabolism in many tissue types
Term
What does GH stimulate release of
Definition
stimulated release of ILGFs (insuin like growth factors, previoulsy called somatomedins, by the liver
Term
GH secretion is regulated by
Definition
growth hormone releasing hormone (GHRH) and growth hormone inhibiting hormone (GHIH)
Term
Luteinizing homrone (LH) and Follicle stimulating hormone (FSH)
Definition
regulate various aspects of reproductive system, in both males and females
Term
Luteinizing homrone (LH) and Follicle stimulating hormone (FSH)are released in response to
Definition
release of gonadotropin releasing hormone (GnRH) by the hypothalamus
Term
Anterior Pituitary Gland Hormones
Definition
Prolactin
Thyroid stimulating hormone (TSH)
Adrenocorticotropic hormone (ACTH)
Growth hormone (GH)
Luteinizing hormone (LH)
Follicle stimulating hormone (FSH)
Term
Adrenal Glands -Location
Definition
superior to kidneys
Term
Adrenal Cortex - Outer portion
secretes what
Definition
Aldosterone
Glucocorticoids
Adrogens
Term
Aldosterone
Definition
causes the kidneys to decrease blood K+ levels, and prevent decreases in blood Na+ levels
Term
What triggers secretion of aldosterone
Definition
increase blood K+ levels
Decrease blood pressure (activates the renin-angiotension-aldosterone system)
Term
Glucose sparing
Definition
when cells do not transport glucose into the cytosol, usually so that the glucose is reserved for neurons
Term
What triggers secretion of glucocorticoids
Definition
ACTH secretion by the pituitary gland
Term
What promotes gluconeogenesis in the liver
Definition
cortisol
Term
permissiveness
Definition
phenomenonin which one hormone is needed for another hormone to exert is actions
Term
antagonism
Definition
in endocrine system, when one hormone opposes the actions of another hormone
Term
synergistic
Definition
pertaining to a process in which the net effect is greater than the sum of the individual effects
Term
What hormone is a stimulating hormone and can also be a inhibiting hormone
Definition
Tropic hormone
Term
Prolactin releasing hormone (PRH)
Definition
Stimulates the anterior pituitary to release prolactn, which stimulates mammary gland development and milk secretion in females
Term
Prolactin inhibiting hormone (PIH)
Definition
or dopamine, inhibits the release of prolactin
Term
Thyrotropin releasing hormone (TRH)
Definition
stimulates the release of thyroid stimulating hormone (TSH) form the anterior pituitary. TSH then stimulates the secretion of thyroid hormones by the thyroid gland
Term
Corticotropin releasing hormone (CRH)
Definition
stimulates the release of adrenocorticotropic hormone (ACTH) by the anterior pituitary. ACTH then stmulates the secretion of other homones by the adrenal cortex, the outer layer of the adrenal gland
Term
Growth Hormone releasin hormone (GHRH)
Definition
Stimulates the secretion of growth hormone (GH) by the anterior pituitary. GH regulates growth and energy metabolism but also functions as a tropic hormone by stimulating the secretion of insulin-like growth factors (IGFs) by the liver
Term
Growth hormone inhibiting hormone (GHIH)
Definition
or somatostatin, inhibits the secretion of growth hormone by the anterior pituitary
Term
Gonadotropin releasing hormone (GnRH)
Definition
stimulates the release of both follicle stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary
Term
What does LH do
Definition
stimulates ovulation in females, and itstimulates the secretion of sex hormones (estrogens and progesterone in females and androgens in males)
Term
What does FSH do
Definition
promotes the development of egg cells in females and sperm cells in makes, and it stimulates the secretion of estrogens in females and inhibin in both sexes
Term
Short loop negative feedback
Definition
prevents the buildup of excess anterior pituitary tropic hormone
Term
Long loop negative feedback
Definition
the hormone whose secretion is timulated by the tropic hormone generally feeds back to the hypothalamus to inhibit secretion of teh tropic hormone, thereby limiting its own secretion
Term
What does the thyroid gland secrete
Definition
tetraiodothyroning (T4) and triiodothyronine (T3) as well as calcitonin
Term
What does the thyroid regulate
Definition
the body's metabolic rate and are necessary for normal growth and development
Term
What does calcitonin regulate that is secreted by the thyroid
Definition
calcium levels in the blood
Term
Parathyroid glands
Definition
secrete parthyroid hormone (PTH) an important regulator of calcium levels in the blood
Term
Thymus
Definition
secretes thymosin - regulates T cell function
Term
What gland is critical for normal immune function because immune cells called T lymphocytes or T Cells, which are essential for effective immune responses against invading microorganisms, mature there
Definition
thymus
Term
Pancreas
Definition
functions as both a endocrine gland and an exocrine gland.
Term
What does the heart secrete
Definition
atrial natriuretic peptide (ANP), which regulates sodium reabsorption by by the kidneys
Term
Kidneys secrete
Definition
erythropoietin, which stimulates production of red blood cells by the bone marrow
Term
Liver secretes
Definition
insulin-like growth factoe (IGFs), which promote tissue growth and bone growth
Term
Skin, liver, kidney
Definition
1,25 dihydroxy vitamin D3
Promotes absorption of calcium by intestine
Term
The concentration of free hormone in the blood depends on three factores
Definition
1) the rate of homoone secretion
2) the amount of hormone trasnported bound to carrier proteins
3) the rate at which the hormone is metabolized
Term
Humoral signals include three basic categories
Definition
1) hormones
2) ions
3) metabolites
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