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Chapter 5
The Structure and Function of Large Biological Molecules
53
Biology
Undergraduate 1
01/25/2012

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Term
four main classes of molecules
Definition
carbohydrates, lipids, proteins, and nucleic acids
Term
macromolecules
Definition
giant molecule formed by the joining of smaller molecules
Term
polymer
Definition
long molecule consisting of many similar or identical building blocks linked by covalent bonds
Term
monomer
Definition
repeating units that serve as the building blocks of a polymer
Term
condensation reaction/ dehydration reaction
Definition
water is the molecule that is lost to make a longer polymer form one short polymer and unlinked monomer
Term
enzymes
Definition
specialized macromolecules that speed up chemical reactions in cells
Term
hydrolysis
Definition
polymers are disassembled to monomers- to break using water
Term
carbohydrates
Definition
includes both sugars and polymers of sugars
Term
monosaccharides
Definition
simplest carbohydrate that have molecular formulas that are some multiple of the unit CH2O
Term
most common monosaccharide
Definition
glucose, C6H12O6
Term
disaccharides
Definition
two monosachharides joined by a glycosidic linkage
Term
glycosidic linkage
Definition
covalent  bond formed between two monosaccharides by a dehydration reaction
Term
polysaccharides
Definition
macromolecules, polymers with a few hundred to a few thousand monosaccharides joined by glycosidic linkages
Term
starch
Definition

polymer of glucose monomers; what plants store as granules within cellular structures known as plastids

 

-molecules are helical

Term
glycogen
Definition

a polysaccharide that animals store; a polymer of glucose that is like amylopectin but more extensively branched

 

-stored in liver and muscle cells

Term
cellulose
Definition

structural polysaccharide that is a major component of the tough walls that enclose plant cells

 

-these molecules are straight

Term
chitin
Definition
important structural polysaccharide, the carbohydrate used by anthropods (insects, spiders, etc) to build their exoskeletons
Term

lipid

 

3 types of lipids

Definition

grouped together because they mix poorly if at all with water

 

-3 types are fats, phospholipids, and steroids

Term
fat
Definition
constructed from 2 smaller types of molecules: glycerol and fatty acids
Term
glycerol
Definition
alcohol with 3 carbons, each bearing a hydroxyl group
Term
fatty acid
Definition
large carbon skeleton between 16-18 carbon atoms in length
Term
triacyglycerol
Definition
consists of 3 fatty acids linked to one glycerol molecule
Term
saturated/ unsaturated fat
Definition

saturated= @ room temp. is a solid

 

unsaturated= @room temp is a liquid <=> cis double bond makes it have some kinks in the fatty acid hydrocarbon chains...not packed together tightly

Term
trans fat
Definition
unsaturated fat containing one or more trans double bonds
Term
phospholipids
Definition

essential for cells b/c they make up cell membranes

 

-consists of hydrophobic tails that point toward the interior of the bilayer, away from the water

Term
steroids
Definition
lipids characterized by a carbon skeleton consisting of four fused rings
Term
cholesterol
Definition
common component of animal cell membranes; precursor from which other steroids are synthesized
Term

functions of proteins

 

 

Definition
speed up chemical reactions, provide structural support, storage, transport, cellular communication, movement, and defense against foreign substances
Term
enzymes
Definition
serves as a catalyst => a chemical agent that changes the rate of reaction w/o being consumed by the reaction
Term
polypeptide
Definition
polymer of amino acids (~20 used)
Term
protein
Definition
one or more polypeptides, each folded and coilde into a specific 3-D structure
Term
amino acid
Definition

organic molecules possesing both carboxyl + amino groups

 

-amino group, alpha carbon, carboxyl group

Term
peptide bond
Definition
C=O to an N-H
Term

globular protein

 

fibrous protein

Definition

globular= roughly spherical

 

fibrous= long fibers

Term
primary structure
Definition
unique sequence of amino acids
Term
secondary structure
Definition
segments of polypeptide chains either coiled or folded in patterns
Term
alpha helix
Definition
delicate coil held together by hydrogen bonding between every fourth amino acid
Term
beta pleated sheet
Definition
2 or more regions of the polypeptide chain lying sided by side are connected by hydrogen bonds between parts of the 2 parallel polypeptide backbones
Term
tertiary structure
Definition
overall shape of a polypeptide resulting from interactions betwen the side chains (R groups) of the various amino acids
Term
quaternary structure
Definition
overall protein structure that results from the aggregation of these polypeptide subunits
Term
denaturation
Definition
protein unravels and loses its shape
Term
chaperonin
Definition
protein molecules that assist in the proper folding of other proteins
Term
X-ray crystallography
Definition
used to determine the 3-D structures of many other proteins
Term
gene
Definition
unit of inheritance
Term
two types of nucleic acids and their definitions
Definition

deoxyribonucleic acid (DNA)= genetic material that organisms inherit from their parents

 

ribonucleic acid (RNA)= protein synthesizer

Term
how to form proteins
Definition
DNA => RNA => proteins
Term
polynucleotides
Definition
macromolecules that exist as polymers
Term
nucleotide
Definition
itself is composed of three parts: a phosphate group, a nitrogenous base, and a 5-carbon sugar
Term
nucleoside
Definition
nitrogeneous base and the sugar
Term
pyrimidine
Definition

nitrogeneous base that has a 6-membered ring of carbon and nitrogen atoms

 

-Cytosine (C)

-Thymine(T)...only DNA

-Uracil (U)...only RNA

Term
purine
Definition

larger, with a 6-membered ring to a 5-membered ring

 

-adenine (A) and guanine (G)

Term
deoxyribose
Definition
lacks an oxygen atom on the second carbon ring
Term
double helix
Definition
two polynucleotides that spin around on an imaginary axis 
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