Term
| Ethanolamines (First Generation H1-Antihistamines) |
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Definition
Mech: Binds to inactive H1 and prevents its activation
Drugs: Diphenhydramine, Carbinoxamine, Clemastine, Dimenhrydrinate
APP: Allergic rhinitis, Anaphylaxis, Insomnia, Motion sickness, Parkinsonism, Urticaria
AE: Sedation, Dizziness, Pupillary dilation, dry eyes and mouth, Urinary retention |
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Term
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Definition
Class: Ethanolamine (1st generation)
CI: Newborns or premauter infants, and nursing mothers
TC: Available as oral solid or liquid, intramuscular, intravenous and topical
TC: May raise Thioridazine plasma levels, increasing the risk of arrhythmias |
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Term
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Definition
Class: Ethanolamine (1st generation)
CI: Acute asthma attack, MAOI therapy, peptic ulcers, severe coronary artery disease and hypertension, and urinary incontinence |
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Term
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Definition
Class: Ethanolamines (1st generation)
CI: Lactation, LRT symptoms, MAOI therapy, and newborn or premature infants |
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Term
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Definition
Class: Ethanolamine (1st generation)
CI: Hypersensitivity to itself |
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Term
| Ethylenediamines (First Generation H1-Antihistamines) |
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Definition
Drugs: Pyrilamine and Tripelennamine
APP: Allergic rhinitis, Anaphylaxis, Insomnia, Motion sickness, Parkinsonism, Urticaria
AE: Sedation, Dizziness, Pupillary dilation, dry eyes and mouth, Urinary retention |
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Term
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Definition
Class: Ehtylenediamines (1st generation)
CI: Hypersensitivity to itself
TC: Available as oral solid or liquid, intramuscular, intravenous, and topical.
TC: May raise Thioridazine levels, increasing risk of arrhythmias |
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Term
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Definition
Class: Ehtylenediamines (1st generation)
CI: Glaucoma, peptic ulcers , prostatic hypertrophy, bladder neck obstruction, pyloroduodenal obstruction
TC: Available as oral solid or liquid, intramuscular, intravenous, and topical.
TC: May raise Thioridazine levels, increasing risk of arrhythmias |
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Term
| Alkylamines (First Generation H1-Antihistamines) |
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Definition
Mech: Binds to inactive H1 and prevents its activation
Drugs: Chlorpheniramine and Brompheniramine
APP: Allergic rhinitis, Anaphylaxis, Insomnia, Motion sickness, Parkinsonism, Urticaria
AE: Sedation, Dizziness, Pupillary dilation, dry eyes and mouth, Urinary retention |
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Term
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Definition
Class: Alkylamines (1st generation)
CI: Hypersensitivity to itself
TC: Available as oral solid or liquid, intramuscular, intravenous, and topical.
TC: May raise Thioridazine levels, increasing risk of arrhythmias |
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Term
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Definition
Class: Alkylamines (1st generation)
CI: Focal CNS lesions, concurrent MAOI therapy
TC: Available as oral solid or liquid, intramuscular, intravenous, and topical.
TC: May raise Thioridazine levels, increasing risk of arrhythmias |
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Term
| Piperidines (First Generation H1-Antihistamines) |
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Definition
Mech: Binds to inactive H1 and prevents its activation
Drugs: Cyproheptadine and Phenindamine
APP: Allergic rhinitis, Anaphylaxis, Insomnia, Motion sickness, Parkinsonism, Urticaria
AE: Sedation, Dizziness, Pupillary dilation, dry eyes and mouth, Urinary retention |
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Term
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Definition
Class: Piperidines (1st generation)
CI: Angle-closure glaucoma, newborn or premature infants, nursing mothers, stenosing peptic ulcer
TC: Available as oral solid or liquid, intramuscular, intravenous, and topical.
TC: May raise Thioridazine levels, increasing risk of arrhythmias |
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Term
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Definition
Class: Piperidines (1st generation)
CI: Children under 12
TC: Available as oral solid or liquid, intramuscular, intravenous, and topical.
TC: May raise Thioridazine levels, increasing risk of arrhythmias |
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Term
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Definition
Class: Phenothiazines (1st generation)
Mech: Binds to inactive H1 and prevents its activation
APP: Allergic rhinitis, Anaphylaxis, Insomnia, Motion sickness, Parkinsonism, Urticaria
AE: Sedation, Dizziness, Pupillary dilation, dry eyes and mouth, Urinary retention, PHOTOSENSITIVITY AND JAUNDICE
CI: COMATOSE STATES, ASTHMA + LRT INFECTIONS, CHILDREN UNDER 2, AND SUBCUTANEOUS OR INTRA-ARTERIAL INJECTION
TC: USED TO RELIEVE PREOPERATIVE ANXIETY AND POST OPERATIVE NAUSEA AND VOMITTING |
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Term
| Piperazines (First generation) |
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Definition
Drugs: Hydroxyzine, Cyclizine, Meclizine
Mech: Binds to inactive H1 and prevents its activation
APP: Pruritis, Alcohol withdrawal, anxiety, vomitting, motion sickness, and vertigo
AE: Sedation, Dizziness, Pupillary dilation, dry eyes and mouth, Urinary retention |
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Term
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Definition
Class: Piperazines (1st generation)
APP: Pruritus, Alchohol withdrawal, anxiety, and vomitting
CI: Early pregnancy
TC: Antipuritic |
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Term
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Definition
Class: Piperazines (1st generation)
APP: Motion sickness, vertigo
CI: Hypersensitivity to self |
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Term
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Definition
Class: Tricyclic dibenzoxepins (1st generation)
Mech: Binds to inactive H1 and prevents its activation
APP: Anxiety, Depression, and Pruritis
AE: Hypertension, hypotension, agranulocytosis, thrombocytopenia, worsening depression, suicidal thoughts, weight gain, etc..
CI: Glaucoma and Urinary retention
TC: Tricyclic antidepressant, and can cause confusion and disorientation in non depressed patients |
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Term
| Piperazines (Second generation) |
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Definition
Drugs: Cetirizine and Lecocetirizine
Mech: Binds to inactive H1 and prevents its activation
APP: Allergic Rhinitis and Uticaria
AE: Somnolence, dry mouth, headache, fatigue (less than other piperazines)
CI: Allergies to self |
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Term
| Cetirizine and Lecocetirizine |
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Definition
Class: Piperazines (2nd generation)
APP: Allergic Rhinitis and Uticaria |
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Term
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Definition
Class: Alkylamine (2nd generation
Mech: Binds to inactive H1 and prevents its activation
APP: Allergic Rhinitis
AE: Somnolence, dry mouth, headache, fatigue
CI: Concurrent MAOI therapy, severe coronary artery disease and severe hypertension
TC: Less anticholinergic effects than first generation |
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Term
| Piperidines (second generation) |
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Definition
Drugs: Loratadine, Desloratadine, Levocabastine, Eebastine, Mizolastine, Fexofenadine
Mech: Binds to inactive H1 and prevents its activation
APP: Allergic rhinitis and Urticaria
AE: Somnolence, dry mouth, headache, fatigue |
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Term
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Definition
Class: Piperidines (2nd generation)
APP: Allergic rhinitis and Urticaria
CI: Soft contact lenses |
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Term
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Definition
Class: Second generation Phthalazinones
Mech: Binds to inactive H1 and prevents its activation
APP: Allergic Rhinitis, VASOMOTOR RHINITIS, Allergic Conjunctivitis
AE: Somnolence, dry mouth, headache, fatigue, BITTER TASTE AND EPISTAXIS
CI: Concurrent use of Alcohol or CNS depressants
TC: Nasal Spray or ophthalmic solution |
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Term
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Definition
Class: Tricyclic dibenzozipins (2nd generation)
Mech: Binds to inactive H1 and prevents its activation
APP: Allergic Rhinitis and Allergic Conjunctivitis
AE: Somnolence, dry mouth, headache, fatigue, BITTER TASTE AND EPISTAXIS
CI: Concurrent use of Alcohol or CNS depressants
TC: Nasal Spray or ophthalmic solution |
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Term
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Definition
| The compound in the urine used to measure histamine levels |
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Term
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Definition
| Activated for the ingestion of food |
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Term
| Loratadine, Desloratadine, Ebastine, Mizolastine, and Fexofenadine |
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Definition
Class: Piperidines (2nd generation)
APP: Allergic rhinitis and Urticaria
CI: Hypersensitivity to drug |
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