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Chapter 4
Chapter 4
20
Physiology
Undergraduate 3
04/30/2010

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Term
proenzymes
Definition
inactive enzymes
Term
proteolitic activation
Definition
Activation of an enzyme by chopping off a part of the enzyme.
Term
feedback inhibition
Definition

The end product of a metabolic pathway acts as an inhibitory modulator of the pathway. Synonym: end-product inhibition 
Term
RNA (ribonucleic acid)
Definition
Nucleotide that interprets the genetic information stored in DNA and uses it to direct protein synthesis
Term
transcription
Definition
Transfer of information coded in DNA to mRNA
Term
messenger RNA (mRNA)
Definition
RNA produced in the nucleus from a DNA template; travels to the cytoplasm to direct the synthesis of new proteins
Term
transfer RNA (tRNA)
Definition

RNA that binds to an amino acid on one end and to ribosomal RNA at the other
Term
ribosomal RNA (rRNA)
Definition
Cytoplasmic RNA where assembly of proteins takes place
Term
translation
Definition
Conversion of the message carried by mRNA into a peptide chain
Term
Constituitively Active
Definition
A gene that is continuosly being translated
Term
RNA polymerase
Definition

Enzyme needed for synthesis of mRNA from DNA
Term
promoter
Definition

Section of DNA near the starting end of a gene that must be activated to begin transcription
Term
transcription factors
Definition
Regulatory proteins that bind  to DNA and alter gene expression
Term
RNA interference
Definition
newly synthesized mRNA is inactivated or destroyed before it can be translated into proteins
Term
Alternative Splicing
Definition
enzyme clip segments out of the middle or off the ends of the mRNA strands
Term
exons
Definition
gene segments that encode proteins
Term
Introns
Definition
segments of genes that do not code for proteins
Term
signal sequence
Definition


Initial segment of a newly-made protein that directs the protein to the proper organelle for processing, packaging, and delivery

 

If there is no signal sequence the protein stays in the cytosol

Term
post-translational modification
Definition
Alterations to a protein molecule made after translation
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