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Chapter 26 Pharm,
Pituitary and Hypothalamus Drugs
13
Pharmacology
Graduate
09/25/2012

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Term
GH stimulates the systemic release of
Definition
IGF-1, longer acting protein to maintain anabolic effects of growth
Term
Ghrelin
Definition
stimulates GH release during fasting
Term
Ghrelin
Definition
stimulates GH release during fasting
Term
Laron Dwarfism
Definition
inability of the liver to secrete IGF-1 in response to GH (tx can not be give more GH)
Term
Sermorelin
Definition
Synthetic GHRH
Term
If lacking sermorelin what can you do to increase GH release
Definition
insulin induced hypoglycemia, glucagon, arginine, clonidine
Term
Somatrophin
Definition
synthetic GH
Term
Mecasermin
Definition
recombinant IGF-1
Term
Octreotide, lanreotide
Definition
somatostatin analogues
Term
Dopamine
Definition
inhibits lactotrophs from releasing prolactin
Term
Dopamine
Definition
stimulates GH release under physiological conditions, but inhibit when used on adenomas GH
Term
Bromocriptine, cabergoline
Definition
Dopamine analogues
Term
Pegvisomant
Definition
GH receptor antagonist
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