Term
| Osteoarthritis (Degenerative Joint Disorder) |
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Definition
Most common joint disease
Progressive erosion of articular cartilage
Knees and hands more commonly affect in women
Hips affected more in men
Aging (increases beyond 50 years)
"Joint Mice" are pieces of cartilage and sub-chondral bone
"Bone Eburnition" = polished ivory
Fibrous walled cysts and osteophytes develop |
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Term
| Osteoarthritis (Degenerative Joint Disorder) |
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Definition
Clinical:
Deep achy pain that worsens with use
Morning stiffness
Neurologic deficits
Joints affected: HIPS, KNEES, LOWER LUMBAR, AND CERVICAL VERTEBRATE
Heberdeen nodes (for women, not for men) |
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Term
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Definition
Women 3-5X more likely than men
Lymphoid aggregates in joint space
"Rice Bodies" (fibrin aggregates)
PANNUS FORMATION (fully grown is called "fibrous alkylosis") |
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Term
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Definition
Path: T-cell mediated (Type IV sensitivity)
Genetic: HLA-DRB1 and PTPN22
Microbes: EBV, Retros, Mycoplasma, etc
Antibodies against:
-Citrullinated Proteins (CCP's)
-Fc portion of autologous IgG (rheumatoid factor) |
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Term
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Definition
SYMMETRICAL AND POLYARTICULAR
Small joints before larger one; 3 or more joints
Swollen, warm, painful, stiff on arising or following inactivity
RADIAL DEVIATION OF THE WRIST, ULNAR DEVIATION OF THE FINGERS (Swan neck and boutonniere also present) |
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Term
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Definition
Abrupt onset
Remitting, high spiking fevers
Migratory and transient skin rash
Hepatosplenomegaly
Serositis |
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Term
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Definition
Four or fewer joints during first 6 months
Absence of psoriasis and HLA-B27 genotype
Younger than 6
associated with iridocylitis and POSITIVIE ANA |
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Term
| JIA: Rheumatoid factor-positive polyarthritis |
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Definition
Presents like adult rheumatoid arthritis
MOST COMMON IN TEENAGE GIRLS |
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Term
| JIA: Rheumatoid factor-negative polyarthritis |
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Definition
More than 5 affected joints
Stiffness and contractions, little/no swelling
Overlaps with oligoarthritis |
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Term
| JIA: Enthsitis-related arthritis |
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Definition
Younger than 6
HLA-B27 positive genotype
Affects tendoligamentous insertion sites and joints of lower extremities |
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Term
Ankylosing Spondyloarthritis
(Marie-Strumpell Disease)
(rheumatoid spondylitis) |
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Definition
Destroys articular cartilage
Sacroiliac and apophyseal joints
Squaring and fusion of vertebral bodies
2nd and 3rd decade of life
low back pain
Hips, knees, and shoulders can happen |
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Term
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Definition
Triad of: Arthritis, Urethritis or Cervicitis, and Conjunctivitis
Affects those with HIV
Immunological to prior infection
Low back pain
Asymmetric affecting ankles, knees, and feet
CHRONIC CONDITION OF THE SPINE IS IDENTICAL TO ANKYLOSING SPONDYLOARTHRITIS |
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Term
| Enteritis-Associated Arthritis |
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Definition
Yersinia, Slamonella, Shigella, and Campylobacter outer cell membranes cause an autoimmune response
Abrupt appearance
Knees, ankles, and sometimes wrists, fingers and toes
LAST A YEAR |
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Term
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Definition
Peripheral and axial joints
30-50 and develops slowly
Asymmetric distribution to DIP's of hands and feet
"SAUSAGE-LIKE FINGERS" |
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Term
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Definition
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