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Chapter 17
The Respiratory System
56
Physiology
Undergraduate 1
04/12/2010

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Term
Partial Pressure
Definition
The contribution of one gas to the total pressure exerted by all gases
Term
In plumonmary capillary beds, oxygen diffuses from
Definition
alveoli to blood
Term
In plumonmary capillary beds, carbon dioxide  diffuses from
Definition
blood to alveoli
Term
In systemic capillary beds, oxygen diffuses from
Definition
blood to the cells
Term
In systemic capillary beds, carbon dioxide diffuses from
Definition
cells to the blood
Term
Because gases are not equally soluble in liquids and in air, they move down their
Definition
partial pressure gradient
Term
At rest we consume how much oxygen per hour
Definition

15 liters per hour

(250 mL per minute)

Term
At rest, we produce how much carbon dioxide per hour
Definition

12 Liters of carbon dioxide

(200 mL per minute)

Term
The amount of O2, that moves into the blood from the air, and the amount of CO2, that moves out of the blood into the air is usually at what concentrations
Definition

in the same location in the blood are relatively constant

The partial pressures at a given location are therefore also relatively constant

Term
The exchange of oxygen and carbon dioxide between alveoli and blood occurs by
Definition
simple diffusion across the respiratory membrane
Term
At what body sites does the partial pressure of carbon dioxide exceed the partial pressure of oxygen
Definition

Cells

systemic veins

the right atrium and ventricle

Term
In the systemic arteries, the partial pressure of oxygen is
Definition
100 mm Hg
Term
In the systemic arteries, the partial pressure of carbon dioxide  is
Definition
40 mm Hg
Term
In the pulmonary veins the partial pressure of oxygen is
Definition
100 mm Hg
Term
In the pulmonary veins the partial pressure of carbon dioxide  is
Definition
40 mm Hg
Term
In the Pulmonary arteries the partial pressure of oxygen is
Definition
40 mm Hg
Term
In the Pulmonary arteries the partial pressure of carbon dioxide  is
Definition
46 mm Hg
Term
In the systemic veins the partial pressure of oxygen is
Definition
40 mm Hg
Term
In the systemic veins the partial pressure of carbon dioxide is
Definition
46 mm Hg
Term
In systemic arteries, the partial pressure of oxygen is 100 mm Hg.  At this partial pressure how much oxygen will be dissoved in the plasma of 1 L of blood
Definition
3 mL of oxygen
Term
Once oxygen diffuses from alveolar air to blood in pulmonary capillaries, it diffuses into
Definition
erythrocytes and binds to hemoglobin for transport in the blood
Term
In the systemic capillaries, hemoglobin in erythrocytes releases oxygen, which then diffuses
Definition
from the blood into tissue cells
Term
What is the oxygen that moves into respiring tissue used for
Definition
to generate ATP through the electron transport chain and oxidative phyosphorylation
Term
Hg, 1 Liter of blood can hold how much oxygen
Definition

200 mL of oxygen

 

3 mL in plasma

197 mL in hemoglobin

Term
Where does hemoglobin tend to pick up O2
Definition
pulmonary capillary beds
Term
Where does hemoglobin drop off O2
Definition
systemic capillary beds
Term
What is the partial CO2 in the systemic veins
Definition
46 mm Hg
Term
If the partial pressure of CO2 in the sytemic veins is 46 mmHg, 1 Liter of blood contains
Definition

31 mL (6%) of CO2 dissolved in plasma

39 mL (7%) of CO2 bound to hemoglobin

470 mL (87%) of CO2 in the form of bicarbonate

Term
What is carbonic anhydrase
Definition
the enzyme that catalyzes reaction one
Term
An increase in affinity of hemoglobin for oxygen causes what type of shift
Definition

leftward shift

  • indicate that a lower PO2 is required to achieve any give level of saturation
  • indicates that oxygen is loaded more easily onto hemoglobin
Term
A decrease in affinity of hemoglobin for oxygen causes what type of shift
Definition

rightward shift

  • indicating that a higher PO2 is required to achieve any given lever of saturation
  • indicates oxygen is unoladed more easity from hemoglobin, making it more available to the tissue
Term
Carbonic Acid
Definition
H2CO3
Term
Bicarbonate
Definition
HCO3
Term
Erthrocytes are able to form bicarbonate because they contain the enzyme
Definition
carbonic anhydrase
Term
What catalyzes the reversible reaction that converts carbon dioxide and water to carbonic acid
Definition

       Carbonic anhydrase

CO2 + H2O <---------------------> H2CO3

Term
An increase in carbon dioxide concentration drives the reaction to the right producing
Definition
more hydrogen and bicarbonate ions
Term
A decrease in carbon dioxide concentraiton drives the reaction to the left producing
Definition
carbon dioxide from hydrogen and bicarbonate ions
Term
If pH falls, solution gains
Definition
H+ ions
Term
If pH rises, solution
Definition
loses H+ ions
Term
H+ and Bicarbonate are removed by the
Definition
Kidneys
Term
The eventual output of inspiratory neurons is to stimulate contraction of the
Definition

diaphrapgm, via the phrenic nerve

 

and

 

the external intercostal muscles via the external intercostal nerves

Term
What activates chemoreceptors in the walls of systemic arteries
Definition
increases in H+ concentration, which occurs due to increases in CO2 levels in the blood
Term
The respiratory control centers respond to activation of chemoreceptors by increasing
Definition
ventilation (breathing reate and force) which helps to reduce CO2 levels
Term
Peripheral chemoreceptors can be activated by
Definition
decreased O2 levels, but only when O2 levels drop severely low
Term
Receptors in the trachea or in the pharynx and nose recognize pollutants and some chemicals
Definition
irritant receptors
Term
When muscles and joints are used what type of receptor is this
Definition
Proprioceptors
Term
An increase in ventilation to meet an increase in the metabolic demands of the body
Definition
Hyperpnea
Term
Labored or difficult breathing
Definition
Dyspnea
Term
Temporary cessation of breathing
Definition
Apnea
Term
Rapid, shallow breathing
Definition
Tachypnea
Term
A condition in which ventilation exceeds the metabolic demands of the body
Definition
Hyperventilation
Term
A condition in which ventilation is insufficient to meet the metabolic demands of the body
Definition
Hypoventilation
Term
A deficiency of oxygen in the tissue
Definition
Hypoxia
Term
A deficiency of oxygen in the blood
Definition
Hypoxemia
Term
An excess of carbon dioxide in the blood
Definition
Hypercapnia
Term
A deficiency of carbon dioxide in the blood
Definition
Hypocapnia
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