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Details Title: Chapter 16 Description: Amines and Amides Total Flash Cards: 32 Created: 08/18/2006 20:47:35	To study from this set of flash cards, or to create your own your own study flash cards, register HERE. If you are already a registered user, CLICK HERE.
Cards Term what functional group is found in more medications than any other type of functional group? Definition nitrogen-containing functional groups Term Amines Definition oreganic derivatives of ammonia in which one or more of the hydrogens are replaced by an aromatic or alkyl group Term what categories are amines put into Definition primary, secondary, tertiary Term primary amine Definition the nitrogen is attached to one other R group Term secondary amine Definition the nitrogen is bonded to two R groups Term what suffix is used when naming amines? Definition -amine Term amino group Definition NH2 Term what is the simplest aromatic amine? Definition aniline Term which forms the strongest hydrogen bonds: amines or alcohols? Definition alcohols Term why? Definition because nitrogen is less electronegative than oxygen Term are the boiling points for amines higher or lower than alcohols? Definition lower Term the bp for tertiary amines is less than the other amines. Why? Definition because tertiary amines are not able to form hydrogen bonds among themselves Term Amines with fewer than (?) carbons are soluble in water? Definition 6 Term what is the most distinguishing feature of amines? Definition their behavior as weak bases Term in acidic solution, is the salt or amine favored Definition salts Term how are quaternary ammonium salts different from other ammonium salts Definition there is no hydrogen attached Term amines reac with acid chlorides or acid anhydrides to form Definition amides Term what is the characteristic functional group of amides Definition a carbonyl group attached to a nitrogen Term amide linkage Definition the single bond linking the carbonyl carbon and nitrogen atoms in the group Term what must be used in the formation of amides Definition primary and secondary amides Term amphetamines Definition a class of drugs structurally similar to epinepherine used to stimulate the CNS Term alkaloids Definition a class of nitrogen containing organic compounds obtained from plants Term what state is formamide at room temp? Definition liquid Term what state are all the other unsubstituated amides? Definition solid Term are the mp and bp of amides high or low? Definition high Term why? Definition because amides can form a complex network of intermolecular hydrogen bonds Term why do disubstituated amides have a lower boiling point than monosubstiuated or unsubstituated amides? Definition because the alkyl or aromatic groups attached make less room for hydrogen, thus there is less hydrogen bonding Term are amides water soluble? Definition yes Term are amides basic? Definition no, they are neutral Term during hydrolysis, the amide is cleaved into what two compounds? Definition a carboxylic acid and an amine or ammonia Term what are the products when an amide undergoes hydrolysis under acidic conditions? Definition carboxylic acid and an amine salt Term under basic conditions? Definition carboxylate acid and an amine