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Chapter 14
Infection and Diseases
86
Biology
Undergraduate 2
11/17/2011

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Term
The presence of microbes in or on our body
Definition
Contamination
Term
Overcome the body's external defenses, multiply (growth), and become established in the body;such a successful invasion of the body by a pathogen is called...
Definition
Infection
Term
Overcome the body's external defenses, multiply (growth), and become established in the body;such a successful invasion of the body by a pathogen is called...
Definition
Infection
Term
Disturbance in the state of health
Definition
disease
Term
Microbes that live on and in body without causing apparent harm
Definition
Normal flora
Term
What are the two types of normal flora?
Definition
permanent and transient
Term
what body parts do not have normal flora?
Definition
brain, blood, urinary tract, urethra, alveoli of the lungs
Term
What are the three conditions where normal microbiota become opportunistic?
Definition
immune supression, changes in normal microbiota, and normal microbiota in an unusual area
Term
What are the types of symbiosis?
Definition
Mutualism, commensalism, and parasitism
Term
In _____ both members benefit from interaction.
Definition
Mutualism
Term
What is an example of mutualism?
Definition
E.coli in colon
Term
In _______ one member of the relationship benefits without effecting the other.
Definition
commensalism
Term
What is an example of commensalism?
Definition
Staphlococcus epidermis on the skin
Term
In _______ one harms the other.
Definition
parasitism
Term
What is an example of parasitism?
Definition
tuberculosis in lungs or scabies
Term
Colonization of normal flora in newborns occurs...
Definition
24-48 hours after birth
Term
When does the baby first come in contact with normal flora?
Definition
During birth, 1st breath, and 1st feeding
Term
Toxoplasma gondii/taxoplasmosis
treponema pallidum/syphilis
listeria monocytogenes/listerosis
cytomegalovirus/adult asymptomatic
parovirus B19/erythema infectiosum
lentivirus (HIV)/AIDS
rubivirus/german measles

These are examples of what?
Definition
pathogens that can cross the placenta
Term
What are the 3 ways normal flora protect our bodies?
Definition
prevent attachment of invaders, deplete essential nutrients, produce antimicrobial substances.
Term
What antimicrobial substance does the normal flora E.coli produce?
Definition
Bacteriocin
Term
What does bacteriocin do ?
Definition
kills other pathogens like samonella and shigella in the colon
Term
What bacteria lowers the pH of the vagina to prevent pathogens?
Definition
lactic acid bacteria
Term
Pseudomona aerogenosa and staphylococcus aureus are examples of what?
Definition
Causes of nosocomial infections
Term
What are adhesion factors in protozoa?
Definition
adhesion disks
Term
What are adhesion factors in helminths?
Definition
suckers and hooks
Term
Surface lipoproteins and glycoproteins that are used for adhesion are called what?
Definition
ligands
Term
Adhesins, ligands are examples of what?
Definition
Attachment proteins
Term
Specialized structures the aid in attachment of pathogens to cells?
Definition
capsule, slime layer, pili, and fimbrae
Term
Enzymes,toxins,antiphagocytic factors, and antiphagocytic chemicals are what?
Definition
Virulence factors
Term
What is the action of hyaluronidase?
Definition
Digests hyalauronic acid, the "glue" that holds animal cells together allowing bacteria to invade deeper tissues.
Term
What is the action of collagenase?
Definition
Digests collagen to be able to get into deeper tissues?
Term
What is the action of coagulase?
Definition
Coagulate blood proteins to get a hiding place/protection from blood proteins.
Term
What is the action of streptokinase?
Definition
digests blood clot to invasion of damaged tissues
Term
Hyaluronidase, collagenase, coagulase, and kinases are examples of what?
Definition
extracellular enzymes that are a virulence factor
Term
What does some bacteria secrete that are central to their pathogenicity in that they destroy host cells or interfere with host metabolism?
Definition
exotoxins
Term
What are three examples of exotoxins?
Definition
cytotoxins, enterotoxins, neurotoxins
Term
What causes botulism, tetanus, gas gangrene, diptheria, cholera, plague, staphylococcal food poisoning?
Definition
exotoxins/clostridia/S.aureus
Term
What is an example of an antiphagocytic factor?
Definition
Bacterial capsule
Term
Why would a bacteria hide in a capsule and how does the capsule effectively hide the bacteria?
Definition
hide from macrophages (wbc) so they dont engulf and remove them. Most capsules are made of chemicals that are similar to ones in the body so they dont stimulate an immune response.
Term
An antiphagocytic chemical that kills wbc?
Definition
leukocidins
Term
What prevents fusion of lysosome and phagocytic vesicles to the bacteria?
Definition
Antiphagocytic chemicals (M protein)
Term
Ear wax, broken skin, skin flakes, feces, seminal vesicles, urine, vaginal secretions, blood, sputum, saliva are examples of what?
Definition
portals of exit
Term
Sites where pathogens are maintained as a source of infection are?
Definition
reservoir of infection
Term
What are the three types of reservoirs of infection?
Definition
animal, human, nonliving (air, water,food)
Term
What are the three modes of transmission?
Definition
contact, vehicle, and vector
Term
Direct, fomites (indirect) and droplets within one meter are consider what mode of transmission?
Definition
contact
Term
Airborne (over one meter), waterborne and foodborne are consider what mode of transmission?
Definition
vehicle
Term
biological or mechanical are considered what mode of transmission?
Definition
vector
Term
Mosquitos, ticks, fleas, louse, blood sucking flies, blood sucking bug, and mites(chiggers) are what?
Definition
biological vectors
Term
Housefly and cockroaches are consider what?
Definition
mechanical vectors
Term
Malaria, yellow fever, elephantiasis, dengue, viral encephalitis are spread by what?
Definition
mosquitos (anopheles/aedes)
Term
Lyme disease, rocky mountain spotted fever are spread by what?
Definition
ticks (ixodes/dermacentor)
Term
bubonic plague and endemic typhus are spread by what?
Definition
flea (xenopsylla)
Term
epidemic typhus is spread by what?
Definition
Louse (pediculus)
Term
African sleeping sickness, river blindness are spread by what?
Definition
bloodsucking flies (glossina and simulium)
Term
Chagas' disease is spread by what?
Definition
bloodsucking bug (triatoma)
Term
scrub typhus is spread by what?
Definition
mite/chiggers (leptotrombidium)
Term
foodborne infections from shigella, salmonella and e.coli are spread by what?
Definition
housefly (musca) and cockroaches (Blatella and periplaneta)
Term
subjective characteristics that are only felt by the person are called?
Definition
symptoms
Term
objective characteristics that can be measured are called what?
Definition
signs
Term
Pain, nausea, headache, chills, sore throat, fatigue, malaise, itching and abdominal cramps are signs true or false?
Definition
false they are symptoms
Term
swelling, rash or redness, vomiting, diarrhea, fever, pus formation, anemia, leukocytosis, bubo (swollen lymphnodes), and tachy/brady cardia are symptoms true or false?
Definition
false they are signs
Term
groups of signs and symptoms are called
Definition
syndrome
Term
The period start of infection to the 1st time feeling the symtoms (no signs or symptoms during this stage)
Definition
incubation
Term
mild symptoms start, increase in number of pathogens. Vague general symptoms
Definition
prodromal period
Term
What stage of infectious disease could be absent?
Definition
prodromal period
Term
the most severe stage of signs and symptoms. if body doesnt fight them off, could die
Definition
illness
Term
declining symptoms and signs, numbers start to decrease
Definition
decline
Term
no more sign and symptoms and body starts to heal and recover
Definition
convalescence
Term
When a disease comes from another infected host either directly or indirectly
Definition
communicable disease
Term
Influenza, herpes, and tuberculosis are examples what classification of how diseases are spread?
Definition
communicable
Term
If a communicable disease is easily transmitted between hosts, as is the case of chicken pox or measles its called what?
Definition
contagious disease
Term
Diseases that arise outside of hosts from normal microbiota and they are not spread from one host to another.
Definition
noncommunicable diseases
Term
Tetanus and botulism are what classification of disease?
Definition
noncommunicable
Term
In occurence of diseases, the number of new cases divided by given time is what?
Definition
incidence
Term
In occurrence, the number of old cases plus the number of new cases divided by time is called what?
Definition
prevalence
Term
Occurs occasionaly. Few cases occur in US and are scattered are called what frequency?
Definition
sporadic
Term
Diseases that are always present and are continuous are what frequency?
Definition
endemic
Term
When many people are affected within a short period of time and present in certain regions at high rates is called what frequency?
Definition
epidemic
Term
A worldwide epidemic is called what?
Definition
Pandemic
Term
When a disease develops rapidly and last a short time it is called?
Definition
acute
Term
When a disease develops slowly but continual and recurrent it is called?
Definition
chronic
Term
When a disease is between acute and chronic it is called?
Definition
sub-acute
Term
When pathogens remain inactive for long period of time before producing signs and symptoms?
Definition
latent
Term
What is the study of the cause of disease?
Definition
etiology
Term
what is the study of the location, course and transmission of diseases within populations?
Definition
epidemiology
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