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Chapter 14
Cardiovascular Physiology
19
Physiology
Undergraduate 3
10/05/2015

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Term
5 phases of the cardiac cycle
Definition
1. the heart at rest: atrial & ventricular diastole
2. completion of ventricular filling: atrial systole
3. early ventricular contraction & the first heart sound
4. the heart pumps: ventricular ejection
5. ventricular relaxation & the second heart sound
Term
first heart sound (S1)
Definition
created by vibrations following closure of the AV valves; the "lub" of "lub-dup"
Term
Is the volume of blood in the ventricle changing during the isovolumic ventricular contraction phase?
Definition
no!
Term
second heart sound (S2)
Definition
created by the vibrations created by semilunar valve closure; the "dup" of "lub-dup"
Term
Is the volume of blood in the ventricles changing during the isovolumic ventricular relaxation period?
Definition
no!
Term
end-diastolic volume (EDV)
Definition
the volume of blood when maximum filling occurs at the end of ventricular relaxation
Term
end-systolic volume (ESV)
Definition
the volume of blood left in the ventricle at the end of contraction
Term
stroke volume
Definition
the amount of blood pumped by one ventricle during a contraction
Term
cardiac output (CO)
Definition
the volume of blood pumped by one ventricle in a given period of time
Term
contractility
Definition
the intrinsic ability of a cardiac muscle fiber to contract at any given fiber length & is a function of Ca2+ interaction with the contractile filaments
Term
preload
Definition
the degree of myocardial stretch before contraction begins; this stretch represent the load placed on cardiac muscles before they contract
Term
venous return
Definition
used to determine end-diastolic volume; the amount of blood that enters the heart from the venous circulation
Term
3 factors that affect venous return
Definition
1. contraction or compression of veins returning blood to the heart
2. pressure changes in the abdomen & thorax during breathing
3. sympathetic innervation of the veins
Term
skeletal muscle pump
Definition
skeletal muscle contractions that squeeze veins, compressing them & pushing blood toward the heart
Term
respiratory pump
Definition
created by movement of the thorax during inspiration
Term
What is the difference between an inotropic agent & an inotropic effect?
Definition
agent: any chemical that affects contractility
effect: the influence of the agent
Term
phospholamban
Definition
a regulatory protein that allows catecholamines to increase Ca2+ storage
Term
afterload
Definition
the combined load of blood in the ventricle & arterial resistance during ventricular contraction
Term
ejection fraction
Definition
the percentage of EDV ejected with one contraction; a common functional index
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