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Chapter 13: Cardiovascular System
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112
Physiology
Undergraduate 2
11/19/2013

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Term
Cardiovascular System
Definition
Consists of the heart, blood vessels and blood
Term
Heart
Definition
Muscular pump that drives flow of blood through blood vessels.
Term
Blood Vessels
Definition
Conduits through which blood flows
Term
Blood
Definition
Fluid that circulates around the body, carrying materials to and from the cells
Term
How many chambers does the heart consist of?
Definition
4
Term
Atria
Definition
The two upper chambers of the heart that receive blood that returns to the heart
Term
Ventricles
Definition
The two lower chambers of the heart that receive blood from the atria and push blood away from the heart through the blood vessels
Term
Left Heart
Definition
Consists of the left atrium and the left ventricle
Term
Right Heart
Definition
Consists of the right atrium and the right ventricle
Term
Septum
Definition
A wall that separates the left and right side of the heart.
Term
Base of Heart
Definition
The wider upper portion of the heart
Term
Apex of the Heart
Definition
The narrower lower portion of the heart
Term
Vasculature
Definition
The system of blood vessels in the body
Term
Capillaries
Definition
Smallest blood vessels that serve as the site of exchange between blood and interstitial fluid.
Term
Arteries
Definition
Largest blood vessels that transports blood directly from the heart to the organs
Term
Arterioles
Definition
Smaller branches of arteries that deliver blood to the capillaries
Term
Venules
Definition
Blood vessels that carry blood from capillaries to veins
Term
Veins
Definition
Large blood vessels that carry blood back to the heart
Term
Why is the cardiovascular system a closed system?
Definition
Because blood moves from the heart into the vasculature and from the vasculature back to the heart
Term
What happens to blood vessels as they move further away from the heart?
Definition
They become more branched and smaller in size
Term
Erythrocytes
Definition
Red blood cells
Term
Red blood cells contain what protein?
Definition
Hemoglobin which is a molecule that carries oxygen
Term
Leukocytes
Definition
White blood cells which help the body defend against invading microorganisms
Term
Platelets
Definition
Cell fragments which play a significant role in blood clotting
Term
Plasma
Definition
Liquid portion of the blood that is made up of water containing dissolved proteins, electrolytes and other solutes.
Term
What two divisions make up the circulatory system?
Definition
The pulmonary circuit and the systemic circuit
Term
Pulmonary Circuit
Definition
Comprises all the blood vessels within the lungs as well as those connecting the lungs to the heart. Blood is supplied to the pulmonary circuit by the right heart
Term
Systemic Circuit
Definition
Encompasses the blood vessels that don't belong to the pulmonary circuit. Blood is supplied to the systemic circuit by the left heart
Term
Capillary beds
Definition
Dense networks of capillaries where exchange of gases takes place. Found within the Circulatory system.
Term
Pulmonary Capillaries
Definition
Oxygen moves into the blood from air in the lungs while carbon dioxide leaves the blood. Blood that leaves the pulmonary capillaries is oxygenated blood
Term
Sysytemic Capillaries
Definition
Located in all organs and tissues besides the lungs. Oxygen moves out of the blood and carbon dioxide enters due to the cells that consume oxygen and generate carbon dioxide. Blood leaving the systemic capillaries is deoxygenated blood
Term
Aorta
Definition
Major artery whose branches carry blood to capillary beds of all organs and tissues in the systemic circuit.
Term
Venae Cavae
Definition
Two large veins that carry blood into the right atrium.
Superior vena cavae carries blood from parts of the body above the diaphragm.
Inferior vena cavae carries blood from parts of the body below the diaphragm
Term
Pulmonary Arteries
Definition
Carry deoxygenated blood to the lungs
Term
Pulmonary Veins
Definition
Carries oxygenated blood to the left atrium
Term
Parallel Flow
Definition
Blood flow in the systemic circuit
Term
Coronary Arteries
Definition
Arteries which branch off the aorta near its base and run through the heart muscle. Blood in the coronary arteries provide the heart muscle with most of its nourishment.
Term
How does blood flow parallel in the vasculature?
Definition
Left to right-Aorta-Arteries-Arterioles-Capillaries-Venules-Veins
Term
What are the heart capillaries supplied by?
Definition
The coronary arteries
Term
Atrioventricular Valve
Definition
A valve that separates the atrium and the ventricle on each side of the heart. Allows blood to flow from the atrium to the ventricle. AV valves open or close in response to cyclic pressure that occurs with every heart beat.
Term
When atrial pressure is higher than ventricular pressure what occurs to the AV valves?
Definition
Valves open
Term
Bicuspid Valve
Definition
AV valve on the left that consists of two flaps of connective tissue
Term
Mitral Valve
Definition
Another name for the bicuspid valve
Term
Tricuspid Valve
Definition
The right AV valve that has three cusps.
Term
Chordae Tendineae
Definition
Strands of connective tissue that hold valve cusps in place
Term
Semilunar Valves
Definition
Valves found between the ventricles and arteries.
Term
Aortic Valve
Definition
Located between the left ventricle and the aorta
Term
Pulmonary Valve
Definition
Located between the right ventricle and the pulmonary trunk
Term
Aortic and pulmonary valves open when...
Definition
Ventricular pressure becomes lower than arterial pressure (when ventricles contract)
Term
Autorhythmicity
Definition
The ability to generate own rhythm
Term
What are the two types of autorhythmic cells in the heart?
Definition
Pacemaker cells and conduction fibers
Term
Pacemaker Cells
Definition
Initiate action potentials and initiate heart rhythm
Term
Conduction Fibers
Definition
Transmit action potentials through the heart
Term
Conduction System
Definition
Consists pacemaker cells and conduction fibers
Term
Sinoatrial Node (SA node)
Definition
A region in the wall of the upper right atrium where pacemaker cells are concentrated. Determines the heart rate.
Term
Atrioventricular Node (AV node)
Definition
Part of the conduction system of the heart located near the tricuspid valve
Term
What is the pacemaker of the heart?
Definition
The SA node because it has the fastest rate of spontaneous depolarization.
Term
Intercalated Disks
Definition
Gap junctions between adjacent muscle fibers that pass electrical current
Term
internodal pathways
Definition
Systems of conduction fibers that run through the walls of the atria.
Term
AV nodal delay
Definition
Action potential is delayed by about 0.1 seconds.
Term
Bundle of His
Definition
Atrioventricular bundle located in the interventricular septum.
Term
Bundle Branches
Definition
Left and right bundles which conduct impulses to the left and right ventricles
Term
Purkinje Fibers
Definition
Extensive network of branches that spread through the ventricular myocardium from the apex upwards towards the valves.
Term
Why does the AV node rarely initiate contraction?
Definition
1. Impulses that pass through the AV node cause it to go into a refractory period.
2. The SA node has a higher frequency of action potentials
Term
Electrocardiogram (ECG)(EKG)
Definition
Noninvasive means of monitoring the electrical activity of the heart.
Term
How are electrical measurements recorded using an ECG?
Definition
From the data provided by electrodes placed on the skin
Term
What serves as the conductor when using an ECG?
Definition
The patient's body
Term
Einthoven's Triangle
Definition
When recording and ECG, electrodes are placed on an imaginary equilateral triangle surrounding the heart. Corners of the triangle are the right arm, left arm and left leg.
Term
Lead
Definition
Specific pairs of electrodes in which one electrode is designated as the positive electrode and the other is the negative electrode. Each led detects the difference in surface electrical potential between the positive and negative electrodes.
Term
Lead I
Definition
Detects potential at the left arm minus that at the right arm.
Term
Lead II
Definition
Detects potential at the left leg minus that at the right arm.
Term
Lead III
Definition
Detects potential at the left leg minus that at the left arm
Term
What are the three characteristic waveforms of an ECG?
Definition
P wave
QRS complex
T wave
Term
P Wave
Definition
An upward deflection that is due to atrial depolarization.
Term
QRS Complex
Definition
A series of sharp upward and downward deflections due to ventricular depolarization
Term
T Wave
Definition
An upward deflection that is caused by ventricular contractile cell action potential.
Term
Ventricular systole
Definition
Q-T interval or the time form the onset of the QRS complez to the end of the T wave. Time of ventricles contracting
Term
Ventricular diastile
Definition
T-Q segment is the time from the end if the T wave to the beginning of the QRS complex. Time of the ventricles relaxing
Term
R-R Interval
Definition
Time between heart beats.
Term
Sinus Rhythm
Definition
Pace generated by SA node
Term
Tachycardia
Definition
Fast rhythm
Term
Bradycardia
Definition
Slow rhythm
Term
1st Degree Heart Block
Definition
Slowed conduction through the AV node
Term
2nd Degree Heart Block
Definition
Slowed and sometimes stopped conduction through the AV node. Absence of QRS complex and T wave
Term
3rd Degree Heart Block
Definition
Complete loss of conduction through the AV node
Term
Ventricular Fibrillation
Definition
Loss of coordination of electrical activity in the heart. Ventricular muscle depolarize independently
Term
Cardiac Cycle
Definition
All of the events associated with the flow of blood through the heart during a single complete heartbeat.
Term
Systole
Definition
The period of ventricular contraction
Term
Diastole
Definition
The period of ventricular relaxation
Term
Venous Return
Definition
Return of blood from veins to the heart
Term
Ventricular Filling
Definition
Blood exiting the heart and entering the ventricle
Term
Isovolumetric Contraction
Definition
Ventricles are contracting and the volume of blood in them remains constant
Term
Ventricular Ejection
Definition
Blood exits the ventricles
Term
Isovolumetric Relaxation
Definition
Ventricles are relaxing and volume of blood in them remains constant.
Term
Diastolic Pressure
Definition
When aortic pressure reaches a minimum
Term
Systolic Pressure
Definition
When aortic pressure reaches a maximum
Term
Mean Arterial Pressure (MAP)
Definition
The average aortic pressure occurring during the cardiac cycle
Term
End-diastolic Volume (EDV)
Definition
The volume of blood in the ventricle at the end of the diastole. It represents the maximum ventricular volume attained during the cardiac cycle, which is reached just before the beginning of ejection.
Term
End-systolic Volume (ESV)
Definition
The volume of blood in the ventricle at the end of the systole. It represents the minimum ventricular volume, which is attained just after ejection.
Term
Stroke Volume
Definition
The difference between EDV and ESV that represents the volume of blood ejected from the heart during one beat.
Term
Cardiac Output (CO)
Definition
The rate at which a ventricle pumps blood. Represented in liters per minute
Term
Cardiac Output =
Definition
Heart rate x stroke volume
Term
Extrinsic Control
Definition
Regulation of the heart by any factor originating from outside the heart itself
Term
Intrinsic Control
Definition
The function of the heart is regulated by factors originating within the heart itself.
Term
At rest, what system controls the heart
Definition
The parasympathetic system. HR=75
Term
During excitement, what system controls the heart
Definition
The sympathetic system. HR increases.
Term
How is the heart rate determined?
Definition
By the SA node firing frequency
Term
What does epinephrine do to the heart?
Definition
Increases action potential frequency at SA node
Term
Increased sympathetic activity or epinephrine leads to what series of events
Definition
B1 receptors in SA node
Increase open state of Ca2+ and Na+ channels
Increase rate of spontaneous depolarization
Increase heart rate
Term
Increased parasympathetic activity leads to what series of events
Definition
Muscarinic cholinergic receptors in SA node
Increased open state of K+ channels and closed state of Ca2+ channels
Decrease rate of spontaneous depolarization and hyperpolarizes the cell
Decrease heart rate
Term
Starling's Law of the Heart
Definition
When the rate at which blood flows into the heart from the veins changes, the stretch on the ventricular myocardium changes, causing the ventricle to contract with greater or lesser force so that the stroke volume matches the venous return.
Term
When end-diastolic volume increases, stroke volume...
Definition
Increases along with heart rate due to the increased ventricular contraction.
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