Term
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Definition
| RNA polymerase binds to it |
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Term
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Definition
| binding site for repressor |
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Term
| sequence specific regulatory proteins |
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Definition
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Term
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Definition
requires presences of bound protein
help - typically upstream of promoter (i.e. activator) |
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Term
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Definition
repressor prevented from binding (i.e. lactose)
-inhibiting - typically downstream of promoter |
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Term
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Definition
where the effector binds
-gives rise to the structural change of the protein |
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Term
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Definition
| control the ability of activator or repressor proteins to bind to their DNA target sites |
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Term
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Definition
| alloteric site sets this in functional or non-functional mode |
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Term
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Definition
premature termination of transcription - second control mechanism that exists to negatively control transcription
which can fold back on itself, forming a stem-and-loop structure that blocks the RNA polymerase from advancing along the DNA --> has to be 3rd and 4th region folding together, hairpin-loop only works if there is a UUUUU tail right afterward - causes RNA to hall off (termination)
-when tryptophan is present: 3&4 bind loop which terminates transcription
-when tryptophan is low: 2&3 bind because ribosome is stalled at trp codons-transcription continues |
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Term
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Definition
| introductory region of the mRNA → includes the attenuator region, which can fold back on itself, forming a stem-and-loop structure that blocks the RNA polymerase from advancing along the DNA. |
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Term
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Definition
| a segment of DNA that encodes a multigenic mRNA as well as an adjacent common promoter and regulatory region |
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Term
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Definition
| something that allosterically inactivates the repressor (i.e. lactose) |
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Term
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Definition
binds to CAP
low when glucose is present
high when glucose is not <- necessary for activation of lac operon |
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Term
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Definition
| when bound to DNA it physically interacts with RNA polymerase and increases that enzymes affinity for the lac promoter |
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