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Chapter 10
Thomas More College
61
Biology
Undergraduate 1
11/05/2012

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Term
In all living organisms, DNA makes up what?
Definition
the genome
Term
What is binary fussion?
Definition
how prokaryotes divide
Term
Who was the first person to see a chromosome?
Definition
Walter Fleming
Term
How many chromosomes, pairs of chromosomes and sister chromatins do humans have?
Definition
46, 23, 92
Term
What is the chromatin composed of?
Definition
dna complexed with protein
Term
What is the histone?
Definition
the protein the wraps around the nucleosome
Term
What are the levels of compaction of chromosomes?
Definition
high, low, and mid
Term
what happens in the less compaction of the chromsomes?
Definition
it is used if the dna wants to be transcribed
Term
what happens in the high compaction of chromosomes?
Definition
dna needs to be replicated
Term
what are the heterochromatin?
Definition
the chromosomes that are tightly compacted and never losen up
Term
what are euchromatin?
Definition
these are the rest of the chromosomes, they make up 92 percent of them
Term
what is the karotype?
Definition
the arrangment of chromosomes by size, staining properties, location of centromer, each is paired with a twin
Term
what is the diploid state?
Definition
they are somatic cells, they are also paired and have a homolog
Term
what is the haploid state?
Definition
gametes, one of each homolog
Term
In order for a cell to divide it has to what?
Definition
go through the phases of the cell cycle 
Term
what are sister chromatids?
Definition
the 2 twin and homologous chromosomes held together, they are used when dna is replicated
Term
what is the longest phase of the cell cycle?
Definition
g1 phase
Term
what happens in the synthesis phase?
Definition
it goes from 46 chromosomes to 92 sister chromatids
Term
what is g0?
Definition
it is not in the cell cycle, it is not active and is in the resting stage. 
Term
describe the g2 phase?
Definition
the secondary growth phase, buffer between mitosis and dna synthesis
Term
what is the interphase stage made up of?
Definition
g1, g2, and s
Term
name the order of the cell cycle
Definition
g1, synthesis, g2, mitosis, and then cytokinesis
Term
what is mitosis?
Definition
Mitosis is nuclear division plus cytokinesis, and produces two identical daughter cells
Term
what happens in the prophase section of mitosis?
Definition
  • chromosomes condense and appear as two sister chromatids held together at centromere
  • cytoskeleton is disassembled and spindle begins to form
  • golgi and er are dispersed
  • nuclear envelope breaks down
Term
what happens in the prometaphase stage of mitosis?
Definition
  • chromosomes attach to microtubles at the kinetochore
  • kinetchores are attached to microtubles from opposite poles
  • chromosomes move to the equator of the cell
Term
what happens in the metaphase stage of mitosis?
Definition
  • all chromsomes align at the metaphase plate
  • chrosomes are attached to opposite poles
Term
what happens in the anaphase stage of mitosis?
Definition
  • individual chromsomes are freed by the degrading of proteins holding them together
  • anaphase a- chromsomes are pulled to opposite poles
  • anaphase b- spindle poles move apart 
Term
what happens in the telophase stage in mitosis?
Definition
  • chromsomes decondense
  • nuclear envelope, golgi complex, and ER re-form
Term
what happens in cytokinesis?
Definition
It is the process of splitting the daughter cells apart. In an animal cell, cleaveage furrow formrs to divide cells. In a plant cell, a cell plate forms to divide cells. 
Term
What happens if cells never went into a resting stage?
Definition
they would over replicate
Term
What happens when there is a loss of control in the cell cycle?
Definition
cancer forms
Term
What are the point of check points?
Definition
to monitor external and internal factors
Term
what are the check points in the cell cycle?
Definition
g1/s, g2/m, spindle
Term
what happens at the g1/s checkpoint?
Definition
determines whether to continue or stop, its a pause
Term
what happens in the g2/m checkpoint?
Definition
it makes sure replication has occureed
Term
what happens in the spindle checkpoint?
Definition
make sure the microtubles attach appropriately and the spindle appartus
Term
What are protocogens?
Definition
the good genes
Term
what are ocogens?
Definition
they are mutated proteins
Term
what are p53?
Definition
genes associated with cancer
Term
genes code for what?
Definition
proteins
Term
Name the stages of binary fission.
Definition

1. the bacterial dna replicates at an origin of replication

2. the bacterial enzymes move out in both directions and make copies of each strand in the dna complex, they continue until they meet at the terminies of replication.

3. the cell elognates with replication and the dna is positioned at the 1/4 and 3/4 spots

4. septation then begins, there is a septum built at the midpoint, faciliated by fts2

Term
what is the range of chromosome pairs?
Definition
0 to 500
Term
what is chromatin made up of? and what is it the site of?
Definition
dna and protein, rna synthesis
Term
how many histones is the dna complex wrapped around?
Definition
8
Term
What is special about the histone?
Definition
it is positive because of the abudance of amino acids
Term
what is a condensin?
Definition
a protein complex involved in the condensation of chromosomes during meiosis and mitosis
Term
maternal and paternal chromosomes are what?
Definition
homologous
Term
what are cohesins?
Definition
the complex of proteins that holds together dna molecules
Term
What are chromatids?
Definition
when chromosomes condense and become visible as two strands
Term
What is the centromere?
Definition
point of constriction on the chromosomes contrainign certain repeated dna sequences that bind specific proteins
Term
what is the kinetochore?
Definition
disk functions as an attachment for mictroubles
Term
what protein that forms microtubles?
Definition
tublin
Term
what are asters and what kind of cells are they found in?
Definition
asters brace the centrioles against the membrane and stiffens the point of microtublar attachment, and animal cells. 
Term
What intiates the prometaphase?
Definition
the disassembly of the nuclear envelope
Term
what are two forces that move chromosomes?
Definition
assembly and disassembly of microtubles, and motor proteins
Term
what signals metaphase?
Definition
the alignment of chromsomes
Term
What is the metaphase plate?
Definition
an imaginary plate perpendicular to the spindle
Term
what is the shortest phase of mitosis?
Definition
anaphase
Term
What is the actually "splitting" step of the cell cycle?
Definition
cytokinses
Term
what is different about mitosis in fungi and some protists?
Definition
the nuclear evelope doesnt dissolve and mitosis takes place in the nucleus
Term
What is cycle dependent kinase activated by?
Definition
cyclin
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